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Cerebellar Cortex and Cerebellar White Matter Volume in Normal Cognition, Mild Cognitive Impairment, and Dementia

The cerebellum is commonly viewed as a structure that is primarily responsible for the coordination of voluntary movement, gait, posture, and speech. Recent research has shown evidence that the cerebellum is also responsible for cognition. We analyzed 28 participants divided into three groups (9 wit...

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Autores principales: Zdanovskis, Nauris, Platkājis, Ardis, Kostiks, Andrejs, Grigorjeva, Oļesja, Karelis, Guntis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468434/
https://www.ncbi.nlm.nih.gov/pubmed/34573156
http://dx.doi.org/10.3390/brainsci11091134
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author Zdanovskis, Nauris
Platkājis, Ardis
Kostiks, Andrejs
Grigorjeva, Oļesja
Karelis, Guntis
author_facet Zdanovskis, Nauris
Platkājis, Ardis
Kostiks, Andrejs
Grigorjeva, Oļesja
Karelis, Guntis
author_sort Zdanovskis, Nauris
collection PubMed
description The cerebellum is commonly viewed as a structure that is primarily responsible for the coordination of voluntary movement, gait, posture, and speech. Recent research has shown evidence that the cerebellum is also responsible for cognition. We analyzed 28 participants divided into three groups (9 with normal cognition, 9 with mild cognitive impairment, and 10 with moderate/severe cognitive impairment) based on the Montreal Cognitive Assessment. We analyzed the cerebellar cortex and white matter volume and assessed differences between groups. Participants with normal cognition had higher average values in total cerebellar volume, cerebellar white matter volume, and cerebellar cortex volume in both hemispheres, but by performing the Kruskal–Wallis test, we did not find these values to be statistically significant.
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spelling pubmed-84684342021-09-27 Cerebellar Cortex and Cerebellar White Matter Volume in Normal Cognition, Mild Cognitive Impairment, and Dementia Zdanovskis, Nauris Platkājis, Ardis Kostiks, Andrejs Grigorjeva, Oļesja Karelis, Guntis Brain Sci Article The cerebellum is commonly viewed as a structure that is primarily responsible for the coordination of voluntary movement, gait, posture, and speech. Recent research has shown evidence that the cerebellum is also responsible for cognition. We analyzed 28 participants divided into three groups (9 with normal cognition, 9 with mild cognitive impairment, and 10 with moderate/severe cognitive impairment) based on the Montreal Cognitive Assessment. We analyzed the cerebellar cortex and white matter volume and assessed differences between groups. Participants with normal cognition had higher average values in total cerebellar volume, cerebellar white matter volume, and cerebellar cortex volume in both hemispheres, but by performing the Kruskal–Wallis test, we did not find these values to be statistically significant. MDPI 2021-08-26 /pmc/articles/PMC8468434/ /pubmed/34573156 http://dx.doi.org/10.3390/brainsci11091134 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zdanovskis, Nauris
Platkājis, Ardis
Kostiks, Andrejs
Grigorjeva, Oļesja
Karelis, Guntis
Cerebellar Cortex and Cerebellar White Matter Volume in Normal Cognition, Mild Cognitive Impairment, and Dementia
title Cerebellar Cortex and Cerebellar White Matter Volume in Normal Cognition, Mild Cognitive Impairment, and Dementia
title_full Cerebellar Cortex and Cerebellar White Matter Volume in Normal Cognition, Mild Cognitive Impairment, and Dementia
title_fullStr Cerebellar Cortex and Cerebellar White Matter Volume in Normal Cognition, Mild Cognitive Impairment, and Dementia
title_full_unstemmed Cerebellar Cortex and Cerebellar White Matter Volume in Normal Cognition, Mild Cognitive Impairment, and Dementia
title_short Cerebellar Cortex and Cerebellar White Matter Volume in Normal Cognition, Mild Cognitive Impairment, and Dementia
title_sort cerebellar cortex and cerebellar white matter volume in normal cognition, mild cognitive impairment, and dementia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468434/
https://www.ncbi.nlm.nih.gov/pubmed/34573156
http://dx.doi.org/10.3390/brainsci11091134
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