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Source Identification of Klebsiella pneumoniae Causing Six Episodes of Recurrent Sepsis in an Adolescent That Underwent Hematopoietic Stem Cell Transplantation

Septicemia or bacteremia is one of the leading causes of death worldwide. Long-term tunneled central venous catheters (CVCs) are usually placed in children undergoing chemotherapy or hematopoietic stem cell transplantation (HSCT) for underlying hemato–oncologic malignancies. However, catheter-relate...

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Autores principales: Jo, Suejung, Kang, Hyun Mi, Kim, Seong Koo, Lee, Jae Wook, Chung, Nack-Gyun, Cho, Bin, Jeong, Dae Chul, Park, Yeon-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468436/
https://www.ncbi.nlm.nih.gov/pubmed/34578155
http://dx.doi.org/10.3390/pathogens10091123
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author Jo, Suejung
Kang, Hyun Mi
Kim, Seong Koo
Lee, Jae Wook
Chung, Nack-Gyun
Cho, Bin
Jeong, Dae Chul
Park, Yeon-Joon
author_facet Jo, Suejung
Kang, Hyun Mi
Kim, Seong Koo
Lee, Jae Wook
Chung, Nack-Gyun
Cho, Bin
Jeong, Dae Chul
Park, Yeon-Joon
author_sort Jo, Suejung
collection PubMed
description Septicemia or bacteremia is one of the leading causes of death worldwide. Long-term tunneled central venous catheters (CVCs) are usually placed in children undergoing chemotherapy or hematopoietic stem cell transplantation (HSCT) for underlying hemato–oncologic malignancies. However, catheter-related complications have been reported frequently, and there is high morbidity and mortality related to catheter-line-associated bloodstream infections (CLABSIs). We report a rare case of six episodes of recurrent K. pneumoniae sepsis within a 6-month period in a 12-year-old male adolescent that underwent HSCT for acute lymphoblastic leukemia, despite treatment with susceptible antibiotics. The patient received extensive diagnostic evaluations to find the hidden source; however, failure to discover the primary source led to multiple recurrences. Through enterobacterial repetitive intergenic consensus (ERIC)-PCR, we were able to identify the relationship between the six episodes and recognize the source of bacteremia.
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spelling pubmed-84684362021-09-27 Source Identification of Klebsiella pneumoniae Causing Six Episodes of Recurrent Sepsis in an Adolescent That Underwent Hematopoietic Stem Cell Transplantation Jo, Suejung Kang, Hyun Mi Kim, Seong Koo Lee, Jae Wook Chung, Nack-Gyun Cho, Bin Jeong, Dae Chul Park, Yeon-Joon Pathogens Case Report Septicemia or bacteremia is one of the leading causes of death worldwide. Long-term tunneled central venous catheters (CVCs) are usually placed in children undergoing chemotherapy or hematopoietic stem cell transplantation (HSCT) for underlying hemato–oncologic malignancies. However, catheter-related complications have been reported frequently, and there is high morbidity and mortality related to catheter-line-associated bloodstream infections (CLABSIs). We report a rare case of six episodes of recurrent K. pneumoniae sepsis within a 6-month period in a 12-year-old male adolescent that underwent HSCT for acute lymphoblastic leukemia, despite treatment with susceptible antibiotics. The patient received extensive diagnostic evaluations to find the hidden source; however, failure to discover the primary source led to multiple recurrences. Through enterobacterial repetitive intergenic consensus (ERIC)-PCR, we were able to identify the relationship between the six episodes and recognize the source of bacteremia. MDPI 2021-09-02 /pmc/articles/PMC8468436/ /pubmed/34578155 http://dx.doi.org/10.3390/pathogens10091123 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Jo, Suejung
Kang, Hyun Mi
Kim, Seong Koo
Lee, Jae Wook
Chung, Nack-Gyun
Cho, Bin
Jeong, Dae Chul
Park, Yeon-Joon
Source Identification of Klebsiella pneumoniae Causing Six Episodes of Recurrent Sepsis in an Adolescent That Underwent Hematopoietic Stem Cell Transplantation
title Source Identification of Klebsiella pneumoniae Causing Six Episodes of Recurrent Sepsis in an Adolescent That Underwent Hematopoietic Stem Cell Transplantation
title_full Source Identification of Klebsiella pneumoniae Causing Six Episodes of Recurrent Sepsis in an Adolescent That Underwent Hematopoietic Stem Cell Transplantation
title_fullStr Source Identification of Klebsiella pneumoniae Causing Six Episodes of Recurrent Sepsis in an Adolescent That Underwent Hematopoietic Stem Cell Transplantation
title_full_unstemmed Source Identification of Klebsiella pneumoniae Causing Six Episodes of Recurrent Sepsis in an Adolescent That Underwent Hematopoietic Stem Cell Transplantation
title_short Source Identification of Klebsiella pneumoniae Causing Six Episodes of Recurrent Sepsis in an Adolescent That Underwent Hematopoietic Stem Cell Transplantation
title_sort source identification of klebsiella pneumoniae causing six episodes of recurrent sepsis in an adolescent that underwent hematopoietic stem cell transplantation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468436/
https://www.ncbi.nlm.nih.gov/pubmed/34578155
http://dx.doi.org/10.3390/pathogens10091123
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