Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis

Mitochondria associated membranes (MAM), which are the contact sites between endoplasmic reticulum (ER) and mitochondria, have emerged as an important hub for signaling molecules to integrate the cellular and organelle homeostasis, thus facilitating the adaptation of energy metabolism to nutrient st...

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Detalles Bibliográficos
Autores principales: Zhang, Pengcheng, Konja, Daniels, Zhang, Yiwei, Wang, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468463/
https://www.ncbi.nlm.nih.gov/pubmed/34571844
http://dx.doi.org/10.3390/cells10092195
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author Zhang, Pengcheng
Konja, Daniels
Zhang, Yiwei
Wang, Yu
author_facet Zhang, Pengcheng
Konja, Daniels
Zhang, Yiwei
Wang, Yu
author_sort Zhang, Pengcheng
collection PubMed
description Mitochondria associated membranes (MAM), which are the contact sites between endoplasmic reticulum (ER) and mitochondria, have emerged as an important hub for signaling molecules to integrate the cellular and organelle homeostasis, thus facilitating the adaptation of energy metabolism to nutrient status. This review explores the dynamic structural and functional features of the MAM and summarizes the various abnormalities leading to the impaired insulin sensitivity and metabolic diseases.
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spelling pubmed-84684632021-09-27 Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis Zhang, Pengcheng Konja, Daniels Zhang, Yiwei Wang, Yu Cells Review Mitochondria associated membranes (MAM), which are the contact sites between endoplasmic reticulum (ER) and mitochondria, have emerged as an important hub for signaling molecules to integrate the cellular and organelle homeostasis, thus facilitating the adaptation of energy metabolism to nutrient status. This review explores the dynamic structural and functional features of the MAM and summarizes the various abnormalities leading to the impaired insulin sensitivity and metabolic diseases. MDPI 2021-08-25 /pmc/articles/PMC8468463/ /pubmed/34571844 http://dx.doi.org/10.3390/cells10092195 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Pengcheng
Konja, Daniels
Zhang, Yiwei
Wang, Yu
Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis
title Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis
title_full Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis
title_fullStr Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis
title_full_unstemmed Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis
title_short Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis
title_sort communications between mitochondria and endoplasmic reticulum in the regulation of metabolic homeostasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468463/
https://www.ncbi.nlm.nih.gov/pubmed/34571844
http://dx.doi.org/10.3390/cells10092195
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AT zhangyiwei communicationsbetweenmitochondriaandendoplasmicreticulumintheregulationofmetabolichomeostasis
AT wangyu communicationsbetweenmitochondriaandendoplasmicreticulumintheregulationofmetabolichomeostasis

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