NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer

IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-κB-binding affinity and function to the IκBα protein. In this review we discuss th...

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Detalles Bibliográficos
Autores principales: Espinosa, Lluís, Marruecos, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468488/
https://www.ncbi.nlm.nih.gov/pubmed/34572464
http://dx.doi.org/10.3390/biomedicines9091278
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author Espinosa, Lluís
Marruecos, Laura
author_facet Espinosa, Lluís
Marruecos, Laura
author_sort Espinosa, Lluís
collection PubMed
description IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-κB-binding affinity and function to the IκBα protein. In this review we discuss the main alterations of IκBα found in cancer and whether they are (most likely) associated with NF-κB-dependent or NF-κB-independent (moonlighting) activities of the protein.
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spelling pubmed-84684882021-09-27 NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer Espinosa, Lluís Marruecos, Laura Biomedicines Review IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-κB-binding affinity and function to the IκBα protein. In this review we discuss the main alterations of IκBα found in cancer and whether they are (most likely) associated with NF-κB-dependent or NF-κB-independent (moonlighting) activities of the protein. MDPI 2021-09-21 /pmc/articles/PMC8468488/ /pubmed/34572464 http://dx.doi.org/10.3390/biomedicines9091278 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Espinosa, Lluís
Marruecos, Laura
NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer
title NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer
title_full NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer
title_fullStr NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer
title_full_unstemmed NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer
title_short NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer
title_sort nf-κb-dependent and -independent (moonlighting) iκbα functions in differentiation and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468488/
https://www.ncbi.nlm.nih.gov/pubmed/34572464
http://dx.doi.org/10.3390/biomedicines9091278
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