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3D Printing of Thermo-Sensitive Drugs

Three-dimensional (3D) printing is among the rapidly evolving technologies with applications in many sectors. The pharmaceutical industry is no exception, and the approval of the first 3D-printed tablet (Spiratam(®)) marked a revolution in the field. Several studies reported the fabrication of diffe...

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Autores principales: Abdella, Sadikalmahdi, Youssef, Souha H., Afinjuomo, Franklin, Song, Yunmei, Fouladian, Paris, Upton, Richard, Garg, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468559/
https://www.ncbi.nlm.nih.gov/pubmed/34575600
http://dx.doi.org/10.3390/pharmaceutics13091524
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author Abdella, Sadikalmahdi
Youssef, Souha H.
Afinjuomo, Franklin
Song, Yunmei
Fouladian, Paris
Upton, Richard
Garg, Sanjay
author_facet Abdella, Sadikalmahdi
Youssef, Souha H.
Afinjuomo, Franklin
Song, Yunmei
Fouladian, Paris
Upton, Richard
Garg, Sanjay
author_sort Abdella, Sadikalmahdi
collection PubMed
description Three-dimensional (3D) printing is among the rapidly evolving technologies with applications in many sectors. The pharmaceutical industry is no exception, and the approval of the first 3D-printed tablet (Spiratam(®)) marked a revolution in the field. Several studies reported the fabrication of different dosage forms using a range of 3D printing techniques. Thermosensitive drugs compose a considerable segment of available medications in the market requiring strict temperature control during processing to ensure their efficacy and safety. Heating involved in some of the 3D printing technologies raises concerns regarding the feasibility of the techniques for printing thermolabile drugs. Studies reported that semi-solid extrusion (SSE) is the commonly used printing technique to fabricate thermosensitive drugs. Digital light processing (DLP), binder jetting (BJ), and stereolithography (SLA) can also be used for the fabrication of thermosensitive drugs as they do not involve heating elements. Nonetheless, degradation of some drugs by light source used in the techniques was reported. Interestingly, fused deposition modelling (FDM) coupled with filling techniques offered protection against thermal degradation. Concepts such as selection of low melting point polymers, adjustment of printing parameters, and coupling of more than one printing technique were exploited in printing thermosensitive drugs. This systematic review presents challenges, 3DP procedures, and future directions of 3D printing of thermo-sensitive formulations.
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spelling pubmed-84685592021-09-27 3D Printing of Thermo-Sensitive Drugs Abdella, Sadikalmahdi Youssef, Souha H. Afinjuomo, Franklin Song, Yunmei Fouladian, Paris Upton, Richard Garg, Sanjay Pharmaceutics Review Three-dimensional (3D) printing is among the rapidly evolving technologies with applications in many sectors. The pharmaceutical industry is no exception, and the approval of the first 3D-printed tablet (Spiratam(®)) marked a revolution in the field. Several studies reported the fabrication of different dosage forms using a range of 3D printing techniques. Thermosensitive drugs compose a considerable segment of available medications in the market requiring strict temperature control during processing to ensure their efficacy and safety. Heating involved in some of the 3D printing technologies raises concerns regarding the feasibility of the techniques for printing thermolabile drugs. Studies reported that semi-solid extrusion (SSE) is the commonly used printing technique to fabricate thermosensitive drugs. Digital light processing (DLP), binder jetting (BJ), and stereolithography (SLA) can also be used for the fabrication of thermosensitive drugs as they do not involve heating elements. Nonetheless, degradation of some drugs by light source used in the techniques was reported. Interestingly, fused deposition modelling (FDM) coupled with filling techniques offered protection against thermal degradation. Concepts such as selection of low melting point polymers, adjustment of printing parameters, and coupling of more than one printing technique were exploited in printing thermosensitive drugs. This systematic review presents challenges, 3DP procedures, and future directions of 3D printing of thermo-sensitive formulations. MDPI 2021-09-21 /pmc/articles/PMC8468559/ /pubmed/34575600 http://dx.doi.org/10.3390/pharmaceutics13091524 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Abdella, Sadikalmahdi
Youssef, Souha H.
Afinjuomo, Franklin
Song, Yunmei
Fouladian, Paris
Upton, Richard
Garg, Sanjay
3D Printing of Thermo-Sensitive Drugs
title 3D Printing of Thermo-Sensitive Drugs
title_full 3D Printing of Thermo-Sensitive Drugs
title_fullStr 3D Printing of Thermo-Sensitive Drugs
title_full_unstemmed 3D Printing of Thermo-Sensitive Drugs
title_short 3D Printing of Thermo-Sensitive Drugs
title_sort 3d printing of thermo-sensitive drugs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468559/
https://www.ncbi.nlm.nih.gov/pubmed/34575600
http://dx.doi.org/10.3390/pharmaceutics13091524
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