Novel Pyridine Bioisostere of Cabozantinib as a Potent c-Met Kinase Inhibitor: Synthesis and Anti-Tumor Activity against Hepatocellular Carcinoma

Two novel bioisosteres of cabozantinib, 3 and 4, were designed and synthesized. The benzene ring in the center of the cabozantinib structure was replaced by trimethylpyridine (3) and pyridine (4), respectively. Surprisingly, the two compounds showed extremely contrasting mesenchymal–epithelial trans...

Descripción completa

Detalles Bibliográficos
Autores principales: Karmacharya, Ujjwala, Guragain, Diwakar, Chaudhary, Prakash, Jee, Jun-Goo, Kim, Jung-Ae, Jeong, Byeong-Seon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468607/
https://www.ncbi.nlm.nih.gov/pubmed/34575841
http://dx.doi.org/10.3390/ijms22189685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468607/
https://www.ncbi.nlm.nih.gov/pubmed/34575841
http://dx.doi.org/10.3390/ijms22189685

Ejemplares similares