Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions

Gastric carcinoma (GC) represents one of the most common and most lethal malignancies worldwide. The histopathological characterization of GC precursor lesions has provided great knowledge about gastric carcinogenesis, with the consequent introduction of effective strategies of primary and secondary...

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Autores principales: Businello, Gianluca, Angerilli, Valentina, Parente, Paola, Realdon, Stefano, Savarino, Edoardo, Farinati, Fabio, Grillo, Federica, Vanoli, Alessandro, Galuppini, Francesca, Paccagnella, Silvia, Pennelli, Gianmaria, Mastracci, Luca, Saragoni, Luca, Fassan, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468646/
https://www.ncbi.nlm.nih.gov/pubmed/34576114
http://dx.doi.org/10.3390/ijms22189950
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author Businello, Gianluca
Angerilli, Valentina
Parente, Paola
Realdon, Stefano
Savarino, Edoardo
Farinati, Fabio
Grillo, Federica
Vanoli, Alessandro
Galuppini, Francesca
Paccagnella, Silvia
Pennelli, Gianmaria
Mastracci, Luca
Saragoni, Luca
Fassan, Matteo
author_facet Businello, Gianluca
Angerilli, Valentina
Parente, Paola
Realdon, Stefano
Savarino, Edoardo
Farinati, Fabio
Grillo, Federica
Vanoli, Alessandro
Galuppini, Francesca
Paccagnella, Silvia
Pennelli, Gianmaria
Mastracci, Luca
Saragoni, Luca
Fassan, Matteo
author_sort Businello, Gianluca
collection PubMed
description Gastric carcinoma (GC) represents one of the most common and most lethal malignancies worldwide. The histopathological characterization of GC precursor lesions has provided great knowledge about gastric carcinogenesis, with the consequent introduction of effective strategies of primary and secondary prevention. In recent years, a large amount of data about the molecular events in GC development is emerging, flanking the histomorphological descriptions. In this review, we describe the landscape of molecular alterations in gastric pre-invasive lesions with a glance at their potential use in the diagnostic and therapeutic decision-making process.
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spelling pubmed-84686462021-09-27 Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions Businello, Gianluca Angerilli, Valentina Parente, Paola Realdon, Stefano Savarino, Edoardo Farinati, Fabio Grillo, Federica Vanoli, Alessandro Galuppini, Francesca Paccagnella, Silvia Pennelli, Gianmaria Mastracci, Luca Saragoni, Luca Fassan, Matteo Int J Mol Sci Review Gastric carcinoma (GC) represents one of the most common and most lethal malignancies worldwide. The histopathological characterization of GC precursor lesions has provided great knowledge about gastric carcinogenesis, with the consequent introduction of effective strategies of primary and secondary prevention. In recent years, a large amount of data about the molecular events in GC development is emerging, flanking the histomorphological descriptions. In this review, we describe the landscape of molecular alterations in gastric pre-invasive lesions with a glance at their potential use in the diagnostic and therapeutic decision-making process. MDPI 2021-09-14 /pmc/articles/PMC8468646/ /pubmed/34576114 http://dx.doi.org/10.3390/ijms22189950 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Businello, Gianluca
Angerilli, Valentina
Parente, Paola
Realdon, Stefano
Savarino, Edoardo
Farinati, Fabio
Grillo, Federica
Vanoli, Alessandro
Galuppini, Francesca
Paccagnella, Silvia
Pennelli, Gianmaria
Mastracci, Luca
Saragoni, Luca
Fassan, Matteo
Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions
title Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions
title_full Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions
title_fullStr Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions
title_full_unstemmed Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions
title_short Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions
title_sort molecular landscapes of gastric pre-neoplastic and pre-invasive lesions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468646/
https://www.ncbi.nlm.nih.gov/pubmed/34576114
http://dx.doi.org/10.3390/ijms22189950
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