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The Multiple Actions of Amygdalin on Cellular Processes with an Emphasis on Female Reproduction
The present review summarizes the current knowledge on the provenance and properties, metabolism and toxicity, mechanism of action, physiological, and therapeutic roles of amygdalin—a molecule present in the seeds of apricot and other plants—with an emphasis on the action of amygdalin on reproductiv...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468697/ https://www.ncbi.nlm.nih.gov/pubmed/34577581 http://dx.doi.org/10.3390/ph14090881 |
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author | Kolesarova, Adriana Baldovska, Simona Roychoudhury, Shubhadeep |
author_facet | Kolesarova, Adriana Baldovska, Simona Roychoudhury, Shubhadeep |
author_sort | Kolesarova, Adriana |
collection | PubMed |
description | The present review summarizes the current knowledge on the provenance and properties, metabolism and toxicity, mechanism of action, physiological, and therapeutic roles of amygdalin—a molecule present in the seeds of apricot and other plants—with an emphasis on the action of amygdalin on reproductive processes, particularly in the female. Amygdalin influences physiological processes including female reproduction at various regulatory levels via extra- and intracellular signaling pathways regulating secretory activity, cell viability, steroidogenesis, proliferation, and apoptosis. On the other hand, while being metabolized in the body, amygdalin releases significant amounts of cyanide, which may lead to acute health hazard in those individuals who may be at risk. Despite some contradictions in the available data about benefits and toxic effects of amygdalin, its potential applicability at low doses may present a promising tool for regulation of various reproductive and other physiological processes including disease management primarily in cancer phytotherapy, animal production, medicine, and biotechnology. However, further research involving carefully designed dose–response studies is required to overcome the possible side effects of amygdalin and assure its safety as a therapeutic agent. |
format | Online Article Text |
id | pubmed-8468697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84686972021-09-27 The Multiple Actions of Amygdalin on Cellular Processes with an Emphasis on Female Reproduction Kolesarova, Adriana Baldovska, Simona Roychoudhury, Shubhadeep Pharmaceuticals (Basel) Review The present review summarizes the current knowledge on the provenance and properties, metabolism and toxicity, mechanism of action, physiological, and therapeutic roles of amygdalin—a molecule present in the seeds of apricot and other plants—with an emphasis on the action of amygdalin on reproductive processes, particularly in the female. Amygdalin influences physiological processes including female reproduction at various regulatory levels via extra- and intracellular signaling pathways regulating secretory activity, cell viability, steroidogenesis, proliferation, and apoptosis. On the other hand, while being metabolized in the body, amygdalin releases significant amounts of cyanide, which may lead to acute health hazard in those individuals who may be at risk. Despite some contradictions in the available data about benefits and toxic effects of amygdalin, its potential applicability at low doses may present a promising tool for regulation of various reproductive and other physiological processes including disease management primarily in cancer phytotherapy, animal production, medicine, and biotechnology. However, further research involving carefully designed dose–response studies is required to overcome the possible side effects of amygdalin and assure its safety as a therapeutic agent. MDPI 2021-08-30 /pmc/articles/PMC8468697/ /pubmed/34577581 http://dx.doi.org/10.3390/ph14090881 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kolesarova, Adriana Baldovska, Simona Roychoudhury, Shubhadeep The Multiple Actions of Amygdalin on Cellular Processes with an Emphasis on Female Reproduction |
title | The Multiple Actions of Amygdalin on Cellular Processes with an Emphasis on Female Reproduction |
title_full | The Multiple Actions of Amygdalin on Cellular Processes with an Emphasis on Female Reproduction |
title_fullStr | The Multiple Actions of Amygdalin on Cellular Processes with an Emphasis on Female Reproduction |
title_full_unstemmed | The Multiple Actions of Amygdalin on Cellular Processes with an Emphasis on Female Reproduction |
title_short | The Multiple Actions of Amygdalin on Cellular Processes with an Emphasis on Female Reproduction |
title_sort | multiple actions of amygdalin on cellular processes with an emphasis on female reproduction |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468697/ https://www.ncbi.nlm.nih.gov/pubmed/34577581 http://dx.doi.org/10.3390/ph14090881 |
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