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Associations between Clinical Findings and Severity of Diffuse Idiopathic Skeletal Hyperostosis in Patients with Ossification of the Posterior Longitudinal Ligament
Background: This study investigated how diffuse idiopathic skeletal hyperostosis (DISH) influences clinical characteristics in patients with cervical ossification of the posterior longitudinal ligament (OPLL). Although DISH is considered unlikely to promote neurologic dysfunction, this relationship...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468753/ https://www.ncbi.nlm.nih.gov/pubmed/34575250 http://dx.doi.org/10.3390/jcm10184137 |
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author | Hirai, Takashi Nishimura, Soraya Yoshii, Toshitaka Nagoshi, Narihito Hashimoto, Jun Mori, Kanji Maki, Satoshi Katsumi, Keiichi Takeuchi, Kazuhiro Ushio, Shuta Furuya, Takeo Watanabe, Kei Nishida, Norihiro Watanabe, Kota Kaito, Takashi Kato, Satoshi Nagashima, Katsuya Koda, Masao Nakashima, Hiroaki Imagama, Shiro Murata, Kazuma Matsuoka, Yuji Wada, Kanichiro Kimura, Atsushi Ohba, Tetsuro Katoh, Hiroyuki Watanabe, Masahiko Matsuyama, Yukihiro Ozawa, Hiroshi Haro, Hirotaka Takeshita, Katsushi Matsumoto, Morio Nakamura, Masaya Yamazaki, Masashi Matsukura, Yu Inose, Hiroyuki Okawa, Atsushi Kawaguchi, Yoshiharu |
author_facet | Hirai, Takashi Nishimura, Soraya Yoshii, Toshitaka Nagoshi, Narihito Hashimoto, Jun Mori, Kanji Maki, Satoshi Katsumi, Keiichi Takeuchi, Kazuhiro Ushio, Shuta Furuya, Takeo Watanabe, Kei Nishida, Norihiro Watanabe, Kota Kaito, Takashi Kato, Satoshi Nagashima, Katsuya Koda, Masao Nakashima, Hiroaki Imagama, Shiro Murata, Kazuma Matsuoka, Yuji Wada, Kanichiro Kimura, Atsushi Ohba, Tetsuro Katoh, Hiroyuki Watanabe, Masahiko Matsuyama, Yukihiro Ozawa, Hiroshi Haro, Hirotaka Takeshita, Katsushi Matsumoto, Morio Nakamura, Masaya Yamazaki, Masashi Matsukura, Yu Inose, Hiroyuki Okawa, Atsushi Kawaguchi, Yoshiharu |
author_sort | Hirai, Takashi |
collection | PubMed |
description | Background: This study investigated how diffuse idiopathic skeletal hyperostosis (DISH) influences clinical characteristics in patients with cervical ossification of the posterior longitudinal ligament (OPLL). Although DISH is considered unlikely to promote neurologic dysfunction, this relationship remains unclear. Methods: Patient data were prospectively collected from 16 Japanese institutions. In total, 239 patients with cervical OPLL were enrolled who had whole-spine computed tomography images available. The primary outcomes were visual analog scale pain scores and the results of other self-reported clinical questionnaires. Correlations were sought between clinical symptoms and DISH using the following grading system: 1, DISH at T3-T10; 2, DISH at both T3–10 and C6–T2 and/or T11–L2; and 3, DISH beyond the C5 and/or L3 levels. Results: DISH was absent in 132 cases, grade 1 in 23, grade 2 in 65, and grade 3 in 19. There were no significant correlations between DISH grade and clinical scores. However, there was a significant difference in the prevalence of neck pain (but not in back pain or low back pain) among the three grades. Interestingly, DISH localized in the thoracic spine (grade 1) may create overload at the cervical spine and lead to neck pain in patients with cervical OPLL. Conclusion: This study is the first prospective multicenter cross-sectional comparison of subjective outcomes in patients with cervical OPLL according to the presence or absence of DISH. The severity of DISH was partially associated with the prevalence of neck pain. |
format | Online Article Text |
id | pubmed-8468753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84687532021-09-27 Associations between Clinical Findings and Severity of Diffuse Idiopathic Skeletal Hyperostosis in Patients with Ossification of the Posterior Longitudinal Ligament Hirai, Takashi Nishimura, Soraya Yoshii, Toshitaka Nagoshi, Narihito Hashimoto, Jun Mori, Kanji Maki, Satoshi Katsumi, Keiichi Takeuchi, Kazuhiro Ushio, Shuta Furuya, Takeo Watanabe, Kei Nishida, Norihiro Watanabe, Kota Kaito, Takashi Kato, Satoshi Nagashima, Katsuya Koda, Masao Nakashima, Hiroaki Imagama, Shiro Murata, Kazuma Matsuoka, Yuji Wada, Kanichiro Kimura, Atsushi Ohba, Tetsuro Katoh, Hiroyuki Watanabe, Masahiko Matsuyama, Yukihiro Ozawa, Hiroshi Haro, Hirotaka Takeshita, Katsushi Matsumoto, Morio Nakamura, Masaya Yamazaki, Masashi Matsukura, Yu Inose, Hiroyuki Okawa, Atsushi Kawaguchi, Yoshiharu J Clin Med Article Background: This study investigated how diffuse idiopathic skeletal hyperostosis (DISH) influences clinical characteristics in patients with cervical ossification of the posterior longitudinal ligament (OPLL). Although DISH is considered unlikely to promote neurologic dysfunction, this relationship remains unclear. Methods: Patient data were prospectively collected from 16 Japanese institutions. In total, 239 patients with cervical OPLL were enrolled who had whole-spine computed tomography images available. The primary outcomes were visual analog scale pain scores and the results of other self-reported clinical questionnaires. Correlations were sought between clinical symptoms and DISH using the following grading system: 1, DISH at T3-T10; 2, DISH at both T3–10 and C6–T2 and/or T11–L2; and 3, DISH beyond the C5 and/or L3 levels. Results: DISH was absent in 132 cases, grade 1 in 23, grade 2 in 65, and grade 3 in 19. There were no significant correlations between DISH grade and clinical scores. However, there was a significant difference in the prevalence of neck pain (but not in back pain or low back pain) among the three grades. Interestingly, DISH localized in the thoracic spine (grade 1) may create overload at the cervical spine and lead to neck pain in patients with cervical OPLL. Conclusion: This study is the first prospective multicenter cross-sectional comparison of subjective outcomes in patients with cervical OPLL according to the presence or absence of DISH. The severity of DISH was partially associated with the prevalence of neck pain. MDPI 2021-09-14 /pmc/articles/PMC8468753/ /pubmed/34575250 http://dx.doi.org/10.3390/jcm10184137 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hirai, Takashi Nishimura, Soraya Yoshii, Toshitaka Nagoshi, Narihito Hashimoto, Jun Mori, Kanji Maki, Satoshi Katsumi, Keiichi Takeuchi, Kazuhiro Ushio, Shuta Furuya, Takeo Watanabe, Kei Nishida, Norihiro Watanabe, Kota Kaito, Takashi Kato, Satoshi Nagashima, Katsuya Koda, Masao Nakashima, Hiroaki Imagama, Shiro Murata, Kazuma Matsuoka, Yuji Wada, Kanichiro Kimura, Atsushi Ohba, Tetsuro Katoh, Hiroyuki Watanabe, Masahiko Matsuyama, Yukihiro Ozawa, Hiroshi Haro, Hirotaka Takeshita, Katsushi Matsumoto, Morio Nakamura, Masaya Yamazaki, Masashi Matsukura, Yu Inose, Hiroyuki Okawa, Atsushi Kawaguchi, Yoshiharu Associations between Clinical Findings and Severity of Diffuse Idiopathic Skeletal Hyperostosis in Patients with Ossification of the Posterior Longitudinal Ligament |
title | Associations between Clinical Findings and Severity of Diffuse Idiopathic Skeletal Hyperostosis in Patients with Ossification of the Posterior Longitudinal Ligament |
title_full | Associations between Clinical Findings and Severity of Diffuse Idiopathic Skeletal Hyperostosis in Patients with Ossification of the Posterior Longitudinal Ligament |
title_fullStr | Associations between Clinical Findings and Severity of Diffuse Idiopathic Skeletal Hyperostosis in Patients with Ossification of the Posterior Longitudinal Ligament |
title_full_unstemmed | Associations between Clinical Findings and Severity of Diffuse Idiopathic Skeletal Hyperostosis in Patients with Ossification of the Posterior Longitudinal Ligament |
title_short | Associations between Clinical Findings and Severity of Diffuse Idiopathic Skeletal Hyperostosis in Patients with Ossification of the Posterior Longitudinal Ligament |
title_sort | associations between clinical findings and severity of diffuse idiopathic skeletal hyperostosis in patients with ossification of the posterior longitudinal ligament |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468753/ https://www.ncbi.nlm.nih.gov/pubmed/34575250 http://dx.doi.org/10.3390/jcm10184137 |
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