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Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach

One in five cancers is attributed to infectious agents, and the extent of the impact on the initiation, progression, and disease outcomes may be underestimated. Infection-associated cancers are commonly attributed to viral, and to a lesser extent, parasitic and bacterial etiologies. There is growing...

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Autores principales: Rodriguez, Rebecca M., Menor, Mark, Hernandez, Brenda Y., Deng, Youping, Khadka, Vedbar S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468759/
https://www.ncbi.nlm.nih.gov/pubmed/34577130
http://dx.doi.org/10.3390/molecules26185659
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author Rodriguez, Rebecca M.
Menor, Mark
Hernandez, Brenda Y.
Deng, Youping
Khadka, Vedbar S.
author_facet Rodriguez, Rebecca M.
Menor, Mark
Hernandez, Brenda Y.
Deng, Youping
Khadka, Vedbar S.
author_sort Rodriguez, Rebecca M.
collection PubMed
description One in five cancers is attributed to infectious agents, and the extent of the impact on the initiation, progression, and disease outcomes may be underestimated. Infection-associated cancers are commonly attributed to viral, and to a lesser extent, parasitic and bacterial etiologies. There is growing evidence that microbial community variation rather than a single agent can influence cancer development, progression, response to therapy, and outcome. We evaluated microbial sequences from a subset of infection-associated cancers—namely, head and neck squamous cell carcinoma (HNSC), liver hepatocellular carcinoma (LIHC), and stomach adenocarcinoma (STAD) from The Cancer Genome Atlas (TCGA). A total of 470 paired tumor and adjacent normal samples were analyzed. In STAD, concurrent presence of EBV and Selemonas sputigena with a high diversity index were associated with poorer survival (HR: 2.23, 95% CI 1.26–3.94, p = 0.006 and HR: 2.31, 95% CI 1.1–4.9, p = 0.03, respectively). In LIHC, lower microbial diversity was associated with poorer overall survival (HR: 2.57, 95% CI: 1.2, 5.5, p = 0.14). Bacterial within-sample diversity correlates with overall survival in infection-associated cancers in a subset of TCGA cohorts.
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spelling pubmed-84687592021-09-27 Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach Rodriguez, Rebecca M. Menor, Mark Hernandez, Brenda Y. Deng, Youping Khadka, Vedbar S. Molecules Article One in five cancers is attributed to infectious agents, and the extent of the impact on the initiation, progression, and disease outcomes may be underestimated. Infection-associated cancers are commonly attributed to viral, and to a lesser extent, parasitic and bacterial etiologies. There is growing evidence that microbial community variation rather than a single agent can influence cancer development, progression, response to therapy, and outcome. We evaluated microbial sequences from a subset of infection-associated cancers—namely, head and neck squamous cell carcinoma (HNSC), liver hepatocellular carcinoma (LIHC), and stomach adenocarcinoma (STAD) from The Cancer Genome Atlas (TCGA). A total of 470 paired tumor and adjacent normal samples were analyzed. In STAD, concurrent presence of EBV and Selemonas sputigena with a high diversity index were associated with poorer survival (HR: 2.23, 95% CI 1.26–3.94, p = 0.006 and HR: 2.31, 95% CI 1.1–4.9, p = 0.03, respectively). In LIHC, lower microbial diversity was associated with poorer overall survival (HR: 2.57, 95% CI: 1.2, 5.5, p = 0.14). Bacterial within-sample diversity correlates with overall survival in infection-associated cancers in a subset of TCGA cohorts. MDPI 2021-09-17 /pmc/articles/PMC8468759/ /pubmed/34577130 http://dx.doi.org/10.3390/molecules26185659 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rodriguez, Rebecca M.
Menor, Mark
Hernandez, Brenda Y.
Deng, Youping
Khadka, Vedbar S.
Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach
title Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach
title_full Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach
title_fullStr Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach
title_full_unstemmed Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach
title_short Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach
title_sort bacterial diversity correlates with overall survival in cancers of the head and neck, liver, and stomach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468759/
https://www.ncbi.nlm.nih.gov/pubmed/34577130
http://dx.doi.org/10.3390/molecules26185659
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