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Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach
One in five cancers is attributed to infectious agents, and the extent of the impact on the initiation, progression, and disease outcomes may be underestimated. Infection-associated cancers are commonly attributed to viral, and to a lesser extent, parasitic and bacterial etiologies. There is growing...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468759/ https://www.ncbi.nlm.nih.gov/pubmed/34577130 http://dx.doi.org/10.3390/molecules26185659 |
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author | Rodriguez, Rebecca M. Menor, Mark Hernandez, Brenda Y. Deng, Youping Khadka, Vedbar S. |
author_facet | Rodriguez, Rebecca M. Menor, Mark Hernandez, Brenda Y. Deng, Youping Khadka, Vedbar S. |
author_sort | Rodriguez, Rebecca M. |
collection | PubMed |
description | One in five cancers is attributed to infectious agents, and the extent of the impact on the initiation, progression, and disease outcomes may be underestimated. Infection-associated cancers are commonly attributed to viral, and to a lesser extent, parasitic and bacterial etiologies. There is growing evidence that microbial community variation rather than a single agent can influence cancer development, progression, response to therapy, and outcome. We evaluated microbial sequences from a subset of infection-associated cancers—namely, head and neck squamous cell carcinoma (HNSC), liver hepatocellular carcinoma (LIHC), and stomach adenocarcinoma (STAD) from The Cancer Genome Atlas (TCGA). A total of 470 paired tumor and adjacent normal samples were analyzed. In STAD, concurrent presence of EBV and Selemonas sputigena with a high diversity index were associated with poorer survival (HR: 2.23, 95% CI 1.26–3.94, p = 0.006 and HR: 2.31, 95% CI 1.1–4.9, p = 0.03, respectively). In LIHC, lower microbial diversity was associated with poorer overall survival (HR: 2.57, 95% CI: 1.2, 5.5, p = 0.14). Bacterial within-sample diversity correlates with overall survival in infection-associated cancers in a subset of TCGA cohorts. |
format | Online Article Text |
id | pubmed-8468759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84687592021-09-27 Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach Rodriguez, Rebecca M. Menor, Mark Hernandez, Brenda Y. Deng, Youping Khadka, Vedbar S. Molecules Article One in five cancers is attributed to infectious agents, and the extent of the impact on the initiation, progression, and disease outcomes may be underestimated. Infection-associated cancers are commonly attributed to viral, and to a lesser extent, parasitic and bacterial etiologies. There is growing evidence that microbial community variation rather than a single agent can influence cancer development, progression, response to therapy, and outcome. We evaluated microbial sequences from a subset of infection-associated cancers—namely, head and neck squamous cell carcinoma (HNSC), liver hepatocellular carcinoma (LIHC), and stomach adenocarcinoma (STAD) from The Cancer Genome Atlas (TCGA). A total of 470 paired tumor and adjacent normal samples were analyzed. In STAD, concurrent presence of EBV and Selemonas sputigena with a high diversity index were associated with poorer survival (HR: 2.23, 95% CI 1.26–3.94, p = 0.006 and HR: 2.31, 95% CI 1.1–4.9, p = 0.03, respectively). In LIHC, lower microbial diversity was associated with poorer overall survival (HR: 2.57, 95% CI: 1.2, 5.5, p = 0.14). Bacterial within-sample diversity correlates with overall survival in infection-associated cancers in a subset of TCGA cohorts. MDPI 2021-09-17 /pmc/articles/PMC8468759/ /pubmed/34577130 http://dx.doi.org/10.3390/molecules26185659 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rodriguez, Rebecca M. Menor, Mark Hernandez, Brenda Y. Deng, Youping Khadka, Vedbar S. Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach |
title | Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach |
title_full | Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach |
title_fullStr | Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach |
title_full_unstemmed | Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach |
title_short | Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach |
title_sort | bacterial diversity correlates with overall survival in cancers of the head and neck, liver, and stomach |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468759/ https://www.ncbi.nlm.nih.gov/pubmed/34577130 http://dx.doi.org/10.3390/molecules26185659 |
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