Cargando…

Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling

Global data correlate severe vitamin D deficiency with COVID-19-associated coagulopathy, further suggesting the presence of a hypercoagulable state in severe COVID-19 patients, which could promote thrombosis in the lungs and in other organs. The feedback loop between COVID-19-associated coagulopathy...

Descripción completa

Detalles Bibliográficos
Autores principales: Salamanna, Francesca, Maglio, Melania, Sartori, Maria, Landini, Maria Paola, Fini, Milena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468972/
https://www.ncbi.nlm.nih.gov/pubmed/34576172
http://dx.doi.org/10.3390/ijms221810010
_version_ 1784573810241961984
author Salamanna, Francesca
Maglio, Melania
Sartori, Maria
Landini, Maria Paola
Fini, Milena
author_facet Salamanna, Francesca
Maglio, Melania
Sartori, Maria
Landini, Maria Paola
Fini, Milena
author_sort Salamanna, Francesca
collection PubMed
description Global data correlate severe vitamin D deficiency with COVID-19-associated coagulopathy, further suggesting the presence of a hypercoagulable state in severe COVID-19 patients, which could promote thrombosis in the lungs and in other organs. The feedback loop between COVID-19-associated coagulopathy and vitamin D also involves platelets (PLTs), since vitamin D deficiency stimulates PLT activation and aggregation and increases fibrinolysis and thrombosis. Vitamin D and PLTs share and play specific roles not only in coagulation and thrombosis but also during inflammation, endothelial dysfunction, and immune response. Additionally, another ‘fil rouge’ between vitamin D and PLTs is represented by their role in mineral metabolism and bone health, since vitamin D deficiency, low PLT count, and altered PLT-related parameters are linked to abnormal bone remodeling in certain pathological conditions, such as osteoporosis (OP). Hence, it is possible to speculate that severe COVID-19 patients are characterized by the presence of several predisposing factors to bone fragility and OP that may be monitored to avoid potential complications. Here, we hypothesize different pervasive actions of vitamin D and PLT association in COVID-19, also allowing for potential preliminary information on bone health status during COVID-19 infection.
format Online
Article
Text
id pubmed-8468972
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84689722021-09-27 Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling Salamanna, Francesca Maglio, Melania Sartori, Maria Landini, Maria Paola Fini, Milena Int J Mol Sci Review Global data correlate severe vitamin D deficiency with COVID-19-associated coagulopathy, further suggesting the presence of a hypercoagulable state in severe COVID-19 patients, which could promote thrombosis in the lungs and in other organs. The feedback loop between COVID-19-associated coagulopathy and vitamin D also involves platelets (PLTs), since vitamin D deficiency stimulates PLT activation and aggregation and increases fibrinolysis and thrombosis. Vitamin D and PLTs share and play specific roles not only in coagulation and thrombosis but also during inflammation, endothelial dysfunction, and immune response. Additionally, another ‘fil rouge’ between vitamin D and PLTs is represented by their role in mineral metabolism and bone health, since vitamin D deficiency, low PLT count, and altered PLT-related parameters are linked to abnormal bone remodeling in certain pathological conditions, such as osteoporosis (OP). Hence, it is possible to speculate that severe COVID-19 patients are characterized by the presence of several predisposing factors to bone fragility and OP that may be monitored to avoid potential complications. Here, we hypothesize different pervasive actions of vitamin D and PLT association in COVID-19, also allowing for potential preliminary information on bone health status during COVID-19 infection. MDPI 2021-09-16 /pmc/articles/PMC8468972/ /pubmed/34576172 http://dx.doi.org/10.3390/ijms221810010 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Salamanna, Francesca
Maglio, Melania
Sartori, Maria
Landini, Maria Paola
Fini, Milena
Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling
title Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling
title_full Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling
title_fullStr Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling
title_full_unstemmed Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling
title_short Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling
title_sort vitamin d and platelets: a menacing duo in covid-19 and potential relation to bone remodeling
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468972/
https://www.ncbi.nlm.nih.gov/pubmed/34576172
http://dx.doi.org/10.3390/ijms221810010
work_keys_str_mv AT salamannafrancesca vitamindandplateletsamenacingduoincovid19andpotentialrelationtoboneremodeling
AT magliomelania vitamindandplateletsamenacingduoincovid19andpotentialrelationtoboneremodeling
AT sartorimaria vitamindandplateletsamenacingduoincovid19andpotentialrelationtoboneremodeling
AT landinimariapaola vitamindandplateletsamenacingduoincovid19andpotentialrelationtoboneremodeling
AT finimilena vitamindandplateletsamenacingduoincovid19andpotentialrelationtoboneremodeling