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Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling
Global data correlate severe vitamin D deficiency with COVID-19-associated coagulopathy, further suggesting the presence of a hypercoagulable state in severe COVID-19 patients, which could promote thrombosis in the lungs and in other organs. The feedback loop between COVID-19-associated coagulopathy...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468972/ https://www.ncbi.nlm.nih.gov/pubmed/34576172 http://dx.doi.org/10.3390/ijms221810010 |
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author | Salamanna, Francesca Maglio, Melania Sartori, Maria Landini, Maria Paola Fini, Milena |
author_facet | Salamanna, Francesca Maglio, Melania Sartori, Maria Landini, Maria Paola Fini, Milena |
author_sort | Salamanna, Francesca |
collection | PubMed |
description | Global data correlate severe vitamin D deficiency with COVID-19-associated coagulopathy, further suggesting the presence of a hypercoagulable state in severe COVID-19 patients, which could promote thrombosis in the lungs and in other organs. The feedback loop between COVID-19-associated coagulopathy and vitamin D also involves platelets (PLTs), since vitamin D deficiency stimulates PLT activation and aggregation and increases fibrinolysis and thrombosis. Vitamin D and PLTs share and play specific roles not only in coagulation and thrombosis but also during inflammation, endothelial dysfunction, and immune response. Additionally, another ‘fil rouge’ between vitamin D and PLTs is represented by their role in mineral metabolism and bone health, since vitamin D deficiency, low PLT count, and altered PLT-related parameters are linked to abnormal bone remodeling in certain pathological conditions, such as osteoporosis (OP). Hence, it is possible to speculate that severe COVID-19 patients are characterized by the presence of several predisposing factors to bone fragility and OP that may be monitored to avoid potential complications. Here, we hypothesize different pervasive actions of vitamin D and PLT association in COVID-19, also allowing for potential preliminary information on bone health status during COVID-19 infection. |
format | Online Article Text |
id | pubmed-8468972 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84689722021-09-27 Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling Salamanna, Francesca Maglio, Melania Sartori, Maria Landini, Maria Paola Fini, Milena Int J Mol Sci Review Global data correlate severe vitamin D deficiency with COVID-19-associated coagulopathy, further suggesting the presence of a hypercoagulable state in severe COVID-19 patients, which could promote thrombosis in the lungs and in other organs. The feedback loop between COVID-19-associated coagulopathy and vitamin D also involves platelets (PLTs), since vitamin D deficiency stimulates PLT activation and aggregation and increases fibrinolysis and thrombosis. Vitamin D and PLTs share and play specific roles not only in coagulation and thrombosis but also during inflammation, endothelial dysfunction, and immune response. Additionally, another ‘fil rouge’ between vitamin D and PLTs is represented by their role in mineral metabolism and bone health, since vitamin D deficiency, low PLT count, and altered PLT-related parameters are linked to abnormal bone remodeling in certain pathological conditions, such as osteoporosis (OP). Hence, it is possible to speculate that severe COVID-19 patients are characterized by the presence of several predisposing factors to bone fragility and OP that may be monitored to avoid potential complications. Here, we hypothesize different pervasive actions of vitamin D and PLT association in COVID-19, also allowing for potential preliminary information on bone health status during COVID-19 infection. MDPI 2021-09-16 /pmc/articles/PMC8468972/ /pubmed/34576172 http://dx.doi.org/10.3390/ijms221810010 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Salamanna, Francesca Maglio, Melania Sartori, Maria Landini, Maria Paola Fini, Milena Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling |
title | Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling |
title_full | Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling |
title_fullStr | Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling |
title_full_unstemmed | Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling |
title_short | Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling |
title_sort | vitamin d and platelets: a menacing duo in covid-19 and potential relation to bone remodeling |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468972/ https://www.ncbi.nlm.nih.gov/pubmed/34576172 http://dx.doi.org/10.3390/ijms221810010 |
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