Anaerobic Fungal Mevalonate Pathway Genomic Biases Lead to Heterologous Toxicity Underpredicted by Codon Adaptation Indices

Anaerobic fungi are emerging biotechnology platforms with genomes rich in biosynthetic potential. Yet, the heterologous expression of their biosynthetic pathways has had limited success in model hosts like E. coli. We find one reason for this is that the genome composition of anaerobic fungi like P....

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Detalles Bibliográficos
Autores principales: Hillman, Ethan T., Frazier, Elizabeth M., Shank, Evan K., Ortiz-Velez, Adrian N., Englaender, Jacob A., Solomon, Kevin V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468974/
https://www.ncbi.nlm.nih.gov/pubmed/34576881
http://dx.doi.org/10.3390/microorganisms9091986

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468974/
https://www.ncbi.nlm.nih.gov/pubmed/34576881
http://dx.doi.org/10.3390/microorganisms9091986

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