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Antibiotic Prescribing Patterns in Ghana, Uganda, Zambia and Tanzania Hospitals: Results from the Global Point Prevalence Survey (G-PPS) on Antimicrobial Use and Stewardship Interventions Implemented

Antimicrobial resistance (AMR) remains an important global public health issue with antimicrobial misuse and overuse being one of the main drivers. The Global Point Prevalence Survey (G-PPS) of Antimicrobial Consumption and Resistance assesses the prevalence and the quality of antimicrobial prescrip...

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Autores principales: D’Arcy, Nikki, Ashiru-Oredope, Diane, Olaoye, Omotayo, Afriyie, Daniel, Akello, Zainab, Ankrah, Daniel, Asima, Derrick Mawuena, Banda, David C., Barrett, Scott, Brandish, Claire, Brayson, Joseph, Benedict, Peter, Dodoo, Cornelius C., Garraghan, Frances, Hoyelah, Josephyn, Jani, Yogini, Kitutu, Freddy Eric, Kizito, Ismail Musoke, Labi, Appiah-Korang, Mirfenderesky, Mariyam, Murdan, Sudaxshina, Murray, Caoimhe, Obeng-Nkrumah, Noah, Olum, William J’Pathim, Opintan, Japheth Awuletey, Panford-Quainoo, Edwin, Pauwels, Ines, Sefah, Israel, Sneddon, Jacqueline, St. Clair Jones, Anja, Versporten, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469030/
https://www.ncbi.nlm.nih.gov/pubmed/34572704
http://dx.doi.org/10.3390/antibiotics10091122
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author D’Arcy, Nikki
Ashiru-Oredope, Diane
Olaoye, Omotayo
Afriyie, Daniel
Akello, Zainab
Ankrah, Daniel
Asima, Derrick Mawuena
Banda, David C.
Barrett, Scott
Brandish, Claire
Brayson, Joseph
Benedict, Peter
Dodoo, Cornelius C.
Garraghan, Frances
Hoyelah, Josephyn
Jani, Yogini
Kitutu, Freddy Eric
Kizito, Ismail Musoke
Labi, Appiah-Korang
Mirfenderesky, Mariyam
Murdan, Sudaxshina
Murray, Caoimhe
Obeng-Nkrumah, Noah
Olum, William J’Pathim
Opintan, Japheth Awuletey
Panford-Quainoo, Edwin
Pauwels, Ines
Sefah, Israel
Sneddon, Jacqueline
St. Clair Jones, Anja
Versporten, Ann
author_facet D’Arcy, Nikki
Ashiru-Oredope, Diane
Olaoye, Omotayo
Afriyie, Daniel
Akello, Zainab
Ankrah, Daniel
Asima, Derrick Mawuena
Banda, David C.
Barrett, Scott
Brandish, Claire
Brayson, Joseph
Benedict, Peter
Dodoo, Cornelius C.
Garraghan, Frances
Hoyelah, Josephyn
Jani, Yogini
Kitutu, Freddy Eric
Kizito, Ismail Musoke
Labi, Appiah-Korang
Mirfenderesky, Mariyam
Murdan, Sudaxshina
Murray, Caoimhe
Obeng-Nkrumah, Noah
Olum, William J’Pathim
Opintan, Japheth Awuletey
Panford-Quainoo, Edwin
Pauwels, Ines
Sefah, Israel
Sneddon, Jacqueline
St. Clair Jones, Anja
Versporten, Ann
author_sort D’Arcy, Nikki
collection PubMed
description Antimicrobial resistance (AMR) remains an important global public health issue with antimicrobial misuse and overuse being one of the main drivers. The Global Point Prevalence Survey (G-PPS) of Antimicrobial Consumption and Resistance assesses the prevalence and the quality of antimicrobial prescriptions across hospitals globally. G-PPS was carried out at 17 hospitals across Ghana, Uganda, Zambia and Tanzania. The overall prevalence of antimicrobial use was 50% (30–57%), with most antibiotics prescribed belonging to the WHO ‘Access’ and ‘Watch’ categories. No ‘Reserve’ category of antibiotics was prescribed across the study sites while antimicrobials belonging to the ‘Not Recommended’ group were prescribed infrequently. Antimicrobials were most often prescribed for prophylaxis for obstetric or gynaecological surgery, making up between 12 and 18% of total prescriptions across all countries. The most prescribed therapeutic subgroup of antimicrobials was ‘Antibacterials for systemic use’. As a result of the programme, PPS data are now readily available for the first time in the hospitals, strengthening the global commitment to improved antimicrobial surveillance. Antimicrobial stewardship interventions developed included the formation of AMS committees, the provision of training and the preparation of new AMS guidelines. Other common interventions included the presentation of findings to clinicians for increased awareness, and the promotion of a multi-disciplinary approach to successful AMS programmes. Repeat PPS would be necessary to continually monitor the impact of interventions implemented. Broader participation is also encouraged to strengthen the evidence base.
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spelling pubmed-84690302021-09-27 Antibiotic Prescribing Patterns in Ghana, Uganda, Zambia and Tanzania Hospitals: Results from the Global Point Prevalence Survey (G-PPS) on Antimicrobial Use and Stewardship Interventions Implemented D’Arcy, Nikki Ashiru-Oredope, Diane Olaoye, Omotayo Afriyie, Daniel Akello, Zainab Ankrah, Daniel Asima, Derrick Mawuena Banda, David C. Barrett, Scott Brandish, Claire Brayson, Joseph Benedict, Peter Dodoo, Cornelius C. Garraghan, Frances Hoyelah, Josephyn Jani, Yogini Kitutu, Freddy Eric Kizito, Ismail Musoke Labi, Appiah-Korang Mirfenderesky, Mariyam Murdan, Sudaxshina Murray, Caoimhe Obeng-Nkrumah, Noah Olum, William J’Pathim Opintan, Japheth Awuletey Panford-Quainoo, Edwin Pauwels, Ines Sefah, Israel Sneddon, Jacqueline St. Clair Jones, Anja Versporten, Ann Antibiotics (Basel) Article Antimicrobial resistance (AMR) remains an important global public health issue with antimicrobial misuse and overuse being one of the main drivers. The Global Point Prevalence Survey (G-PPS) of Antimicrobial Consumption and Resistance assesses the prevalence and the quality of antimicrobial prescriptions across hospitals globally. G-PPS was carried out at 17 hospitals across Ghana, Uganda, Zambia and Tanzania. The overall prevalence of antimicrobial use was 50% (30–57%), with most antibiotics prescribed belonging to the WHO ‘Access’ and ‘Watch’ categories. No ‘Reserve’ category of antibiotics was prescribed across the study sites while antimicrobials belonging to the ‘Not Recommended’ group were prescribed infrequently. Antimicrobials were most often prescribed for prophylaxis for obstetric or gynaecological surgery, making up between 12 and 18% of total prescriptions across all countries. The most prescribed therapeutic subgroup of antimicrobials was ‘Antibacterials for systemic use’. As a result of the programme, PPS data are now readily available for the first time in the hospitals, strengthening the global commitment to improved antimicrobial surveillance. Antimicrobial stewardship interventions developed included the formation of AMS committees, the provision of training and the preparation of new AMS guidelines. Other common interventions included the presentation of findings to clinicians for increased awareness, and the promotion of a multi-disciplinary approach to successful AMS programmes. Repeat PPS would be necessary to continually monitor the impact of interventions implemented. Broader participation is also encouraged to strengthen the evidence base. MDPI 2021-09-17 /pmc/articles/PMC8469030/ /pubmed/34572704 http://dx.doi.org/10.3390/antibiotics10091122 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
D’Arcy, Nikki
Ashiru-Oredope, Diane
Olaoye, Omotayo
Afriyie, Daniel
Akello, Zainab
Ankrah, Daniel
Asima, Derrick Mawuena
Banda, David C.
Barrett, Scott
Brandish, Claire
Brayson, Joseph
Benedict, Peter
Dodoo, Cornelius C.
Garraghan, Frances
Hoyelah, Josephyn
Jani, Yogini
Kitutu, Freddy Eric
Kizito, Ismail Musoke
Labi, Appiah-Korang
Mirfenderesky, Mariyam
Murdan, Sudaxshina
Murray, Caoimhe
Obeng-Nkrumah, Noah
Olum, William J’Pathim
Opintan, Japheth Awuletey
Panford-Quainoo, Edwin
Pauwels, Ines
Sefah, Israel
Sneddon, Jacqueline
St. Clair Jones, Anja
Versporten, Ann
Antibiotic Prescribing Patterns in Ghana, Uganda, Zambia and Tanzania Hospitals: Results from the Global Point Prevalence Survey (G-PPS) on Antimicrobial Use and Stewardship Interventions Implemented
title Antibiotic Prescribing Patterns in Ghana, Uganda, Zambia and Tanzania Hospitals: Results from the Global Point Prevalence Survey (G-PPS) on Antimicrobial Use and Stewardship Interventions Implemented
title_full Antibiotic Prescribing Patterns in Ghana, Uganda, Zambia and Tanzania Hospitals: Results from the Global Point Prevalence Survey (G-PPS) on Antimicrobial Use and Stewardship Interventions Implemented
title_fullStr Antibiotic Prescribing Patterns in Ghana, Uganda, Zambia and Tanzania Hospitals: Results from the Global Point Prevalence Survey (G-PPS) on Antimicrobial Use and Stewardship Interventions Implemented
title_full_unstemmed Antibiotic Prescribing Patterns in Ghana, Uganda, Zambia and Tanzania Hospitals: Results from the Global Point Prevalence Survey (G-PPS) on Antimicrobial Use and Stewardship Interventions Implemented
title_short Antibiotic Prescribing Patterns in Ghana, Uganda, Zambia and Tanzania Hospitals: Results from the Global Point Prevalence Survey (G-PPS) on Antimicrobial Use and Stewardship Interventions Implemented
title_sort antibiotic prescribing patterns in ghana, uganda, zambia and tanzania hospitals: results from the global point prevalence survey (g-pps) on antimicrobial use and stewardship interventions implemented
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469030/
https://www.ncbi.nlm.nih.gov/pubmed/34572704
http://dx.doi.org/10.3390/antibiotics10091122
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