Cargando…

The Azurin-Derived Peptide CT-p19LC Exhibits Membrane-Active Properties and Induces Cancer Cell Death

Peptides have been thoroughly studied as new therapeutic strategies for cancer treatment. In this work, we explored in vitro the anticancer potential of three novel peptides derived from the C-terminal of azurin, an anticancer bacterial protein produced by Pseudomonas aeruginosa. CT-p26, CT-p19 and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Garizo, Ana Rita, Coelho, Lígia F., Pinto, Sandra, Dias, Tiago P., Fernandes, Fábio, Bernardes, Nuno, Fialho, Arsénio M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469032/ https://www.ncbi.nlm.nih.gov/pubmed/34572379 http://dx.doi.org/10.3390/biomedicines9091194

Ejemplares similares

Conditioned Medium From Azurin-Expressing Human Mesenchymal Stromal Cells Demonstrates Antitumor Activity Against Breast and Lung Cancer Cell Lines
por: Silva, Marília, et al.
Publicado: (2020)

The Bacterial Protein Azurin Impairs Invasion and FAK/Src Signaling in P-Cadherin-Overexpressing Breast Cancer Cell Models
por: Bernardes, Nuno, et al.
Publicado: (2013)

Bacterial proteins and peptides in cancer therapy: Today and tomorrow
por: Chakrabarty, Ananda M, et al.
Publicado: (2014)

Reversible S-Nitrosylation in an Engineered Azurin
por: Tian, Shiliang, et al.
Publicado: (2016)

Perturbing the Dynamics and Organization of Cell Membrane Components: A New Paradigm for Cancer-Targeted Therapies
por: Bernardes, Nuno, et al.
Publicado: (2018)

A Proton ENDOR Study of Azurin
por: Sottini, Silvia, et al.
Publicado: (2009)

The Azurin Coding Gene: Origin and Phylogenetic Distribution
por: Gammuto, Leandro, et al.
Publicado: (2021)

Temperature Dependence of Charge and Spin Transfer in Azurin
por: Sang, Yutao, et al.
Publicado: (2021)

Interaction of an anticancer peptide fragment of azurin with p53 and its isolated domains studied by atomic force spectroscopy
por: Bizzarri, Anna Rita, et al.
Publicado: (2011)

Differences in the mechanical unfolding pathways of apo- and copper-bound azurins
por: Yadav, Anju, et al.
Publicado: (2018)

Sequence-specific destabilization of azurin by tetramethylguanidinium-dipeptide ionic liquids
por: Patel, Roshani, et al.
Publicado: (2022)

Raman Evidence of p53-DBD Disorder Decrease upon Interaction with the Anticancer Protein Azurin
por: Signorelli, Sara, et al.
Publicado: (2019)

Converged Structural and Spectroscopic Properties for Refined QM/MM Models of Azurin
por: Schulz, Christine E., et al.
Publicado: (2021)

Photoinduced Electron Transfer from the Tryptophan Triplet State in Zn-Azurin
por: Rivera, Joel J., et al.
Publicado: (2022)

Analysis of antibacterial and antibiofilm activity of purified recombinant Azurin from Pseudomonas aeruginosa
por: Mohammadi-Barzelighi, Hajar, et al.
Publicado: (2019)

Bacterial delivery of the anti-tumor azurin-like protein Laz to glioblastoma cells
por: Mansour, Manar, et al.
Publicado: (2020)

Frustration Dynamics and Electron-Transfer Reorganization Energies in Wild-Type and Mutant Azurins
por: Chen, Xun, et al.
Publicado: (2022)

Burkholderia cenocepacia transcriptome during the early contacts with giant plasma membrane vesicles derived from live bronchial epithelial cells
por: Pimenta, Andreia I., et al.
Publicado: (2021)

The Bacterial Protein Azurin Enhances Sensitivity of Oral Squamous Carcinoma Cells to Anticancer Drugs
por: Choi, Jeong-Hae, et al.
Publicado: (2011)

Repair of Iron Centers RIC protein contributes to the virulence of Staphylococcus aureus
por: Silva, Liliana O., et al.
Publicado: (2017)

Protein Binding and Orientation Matter: Bias-Induced Conductance Switching in a Mutated Azurin Junction
por: Fereiro, Jerry A., et al.
Publicado: (2020)

Tuning Structure and Dynamics of Blue Copper Azurin Junctions via Single Amino-Acid Mutations
por: Ortega, Maria, et al.
Publicado: (2019)

Mechanical Deformation and Electronic Structure of a Blue Copper Azurin in a Solid-State Junction
por: Romero-Muñiz, Carlos, et al.
Publicado: (2019)

Electrochemical nucleic acid detection based on parallel structural dsDNA/recombinant azurin hybrid
por: Mohammadniaei, Mohsen, et al.
Publicado: (2017)

Single electron transfer events and dynamical heterogeneity in the small protein azurin from Pseudomonas aeruginosa
por: Pradhan, Biswajit, et al.
Publicado: (2019)

Lipid-Modified Azurin of Neisseria gonorrhoeae Is Not Surface Exposed and Does Not Interact With the Nitrite Reductase AniA
por: Baarda, Benjamin I., et al.
Publicado: (2018)

Azurin/CdSe-ZnS-Based Bio-Nano Hybrid Structure for Nanoscale Resistive Memory Device
por: Yagati, Ajay Kumar, et al.
Publicado: (2017)

Electron Transfer Proteins as Electronic Conductors: Significance of the Metal and Its Binding Site in the Blue Cu Protein, Azurin
por: Amdursky, Nadav, et al.
Publicado: (2015)

Global Sequence Analysis and Expression of Azurin Gene in Different Clinical Specimens of Burn Patients with Pseudomonas aeruginosa Infection
por: Mohammadi Barzelighi, Hajar, et al.
Publicado: (2020)

Structural basis of bacterial effector protein azurin targeting tumor suppressor p53 and inhibiting its ubiquitination
por: Hu, Jianjian, et al.
Publicado: (2023)

Efficient Cytotoxicity of Recombinant Azurin in Escherichia coli Nissle 1917-Derived Minicells against Colon Cancer Cells
por: Ma, Yi, et al.
Publicado: (2023)

The construction of the eukaryotic expression plasmid pcDNA3.1/azurin and the increased apoptosis of U2OS cells transfected with it
por: Ye, Zhaoming, et al.
Publicado: (2007)

Trimeric Autotransporter Adhesins in Members of the Burkholderia Cepacia Complex: A Multifunctional Family of Proteins Implicated in Virulence
por: Mil-Homens, Dalila, et al.
Publicado: (2011)

A BCAM0223 Mutant of Burkholderia cenocepacia Is Deficient in Hemagglutination, Serum Resistance, Adhesion to Epithelial Cells and Virulence
por: Mil-Homens, Dalila, et al.
Publicado: (2012)

Stepwise nitrosylation of the nonheme iron site in an engineered azurin and a molecular basis for nitric oxide signaling mediated by nonheme iron proteins
por: Tian, Shiliang, et al.
Publicado: (2021)

In-Silico Analysis Highlights the Existence in Members of Burkholderia cepacia Complex of a New Class of Adhesins Possessing Collagen-like Domains
por: Estevens, Ricardo, et al.
Publicado: (2023)

Continuous Production of Dietetic Structured Lipids Using Crude Acidic Olive Pomace Oils
por: Souza-Gonçalves, Joana, et al.
Publicado: (2023)

Discovery of Azurin-Like Anticancer Bacteriocins from Human Gut Microbiome through Homology Modeling and Molecular Docking against the Tumor Suppressor p53
por: Nguyen, Chuong, et al.
Publicado: (2016)

The functions of azurin of Pseudomonas aeruginosa and human mammaglobin-A on proapoptotic and cell cycle regulatory genes expression in the MCF-7 breast cancer cell line
por: Ghasemi-Dehkordi, Payam, et al.
Publicado: (2020)

Computational Modeling, High-Level Soluble Expression and In Vitro Cytotoxicity Assessment of Recombinant Pseudomonas aeruginosa Azurin: A Promising Anti-Cancer Therapeutic Candidate
por: Aslam, Shakira, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_r4fmgarhlsvr5lvcnhtrhjiih5