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Preconditioned Mesenchymal Stromal Cells to Improve Allotransplantation Outcome

Mesenchymal stromal cells (MSCs) are tissue-derived progenitor cells with immunomodulatory as well as multilineage differentiation capacities, and have been widely applied as cellular therapeutics in different disease systems in both preclinical models and clinical studies. Although many studies hav...

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Autores principales: Cheng, Hui-Yun, Anggelia, Madonna Rica, Lin, Cheng-Hung, Lin, Chih-Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469056/
https://www.ncbi.nlm.nih.gov/pubmed/34571974
http://dx.doi.org/10.3390/cells10092325
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author Cheng, Hui-Yun
Anggelia, Madonna Rica
Lin, Cheng-Hung
Lin, Chih-Fan
author_facet Cheng, Hui-Yun
Anggelia, Madonna Rica
Lin, Cheng-Hung
Lin, Chih-Fan
author_sort Cheng, Hui-Yun
collection PubMed
description Mesenchymal stromal cells (MSCs) are tissue-derived progenitor cells with immunomodulatory as well as multilineage differentiation capacities, and have been widely applied as cellular therapeutics in different disease systems in both preclinical models and clinical studies. Although many studies have applied MSCs in different types of allotransplantation, the efficacy varies. It has been demonstrated that preconditioning MSCs prior to in vivo administration may enhance their efficacy. In the field of organ/tissue allotransplantation, many recent studies have shown that preconditioning of MSCs with (1) pretreatment with bioactive factors or reagents such as cytokines, or (2) specific gene transfection, could prolong allotransplant survival and improve allotransplant function. Herein, we review these preconditioning strategies and discuss potential directions for further improvement.
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spelling pubmed-84690562021-09-27 Preconditioned Mesenchymal Stromal Cells to Improve Allotransplantation Outcome Cheng, Hui-Yun Anggelia, Madonna Rica Lin, Cheng-Hung Lin, Chih-Fan Cells Review Mesenchymal stromal cells (MSCs) are tissue-derived progenitor cells with immunomodulatory as well as multilineage differentiation capacities, and have been widely applied as cellular therapeutics in different disease systems in both preclinical models and clinical studies. Although many studies have applied MSCs in different types of allotransplantation, the efficacy varies. It has been demonstrated that preconditioning MSCs prior to in vivo administration may enhance their efficacy. In the field of organ/tissue allotransplantation, many recent studies have shown that preconditioning of MSCs with (1) pretreatment with bioactive factors or reagents such as cytokines, or (2) specific gene transfection, could prolong allotransplant survival and improve allotransplant function. Herein, we review these preconditioning strategies and discuss potential directions for further improvement. MDPI 2021-09-06 /pmc/articles/PMC8469056/ /pubmed/34571974 http://dx.doi.org/10.3390/cells10092325 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cheng, Hui-Yun
Anggelia, Madonna Rica
Lin, Cheng-Hung
Lin, Chih-Fan
Preconditioned Mesenchymal Stromal Cells to Improve Allotransplantation Outcome
title Preconditioned Mesenchymal Stromal Cells to Improve Allotransplantation Outcome
title_full Preconditioned Mesenchymal Stromal Cells to Improve Allotransplantation Outcome
title_fullStr Preconditioned Mesenchymal Stromal Cells to Improve Allotransplantation Outcome
title_full_unstemmed Preconditioned Mesenchymal Stromal Cells to Improve Allotransplantation Outcome
title_short Preconditioned Mesenchymal Stromal Cells to Improve Allotransplantation Outcome
title_sort preconditioned mesenchymal stromal cells to improve allotransplantation outcome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469056/
https://www.ncbi.nlm.nih.gov/pubmed/34571974
http://dx.doi.org/10.3390/cells10092325
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