Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium

Aberrant centrosome activities in mutants of Dictyostelium discoideum result in anomalies of mitotic spindles that affect the reliability of chromosome segregation. Genetic instabilities caused by these deficiencies are tolerated in multinucleate cells, which can be produced by electric-pulse induce...

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Autores principales: Ecke, Mary, Prassler, Jana, Gerisch, Günther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469108/
https://www.ncbi.nlm.nih.gov/pubmed/34571889
http://dx.doi.org/10.3390/cells10092240
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author Ecke, Mary
Prassler, Jana
Gerisch, Günther
author_facet Ecke, Mary
Prassler, Jana
Gerisch, Günther
author_sort Ecke, Mary
collection PubMed
description Aberrant centrosome activities in mutants of Dictyostelium discoideum result in anomalies of mitotic spindles that affect the reliability of chromosome segregation. Genetic instabilities caused by these deficiencies are tolerated in multinucleate cells, which can be produced by electric-pulse induced cell fusion as a source for aberrations in the mitotic apparatus of the mutant cells. Dual-color fluorescence labeling of the microtubule system and the chromosomes in live cells revealed the variability of spindle arrangements, of centrosome-nuclear interactions, and of chromosome segregation in the atypical mitoses observed.
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spelling pubmed-84691082021-09-27 Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium Ecke, Mary Prassler, Jana Gerisch, Günther Cells Communication Aberrant centrosome activities in mutants of Dictyostelium discoideum result in anomalies of mitotic spindles that affect the reliability of chromosome segregation. Genetic instabilities caused by these deficiencies are tolerated in multinucleate cells, which can be produced by electric-pulse induced cell fusion as a source for aberrations in the mitotic apparatus of the mutant cells. Dual-color fluorescence labeling of the microtubule system and the chromosomes in live cells revealed the variability of spindle arrangements, of centrosome-nuclear interactions, and of chromosome segregation in the atypical mitoses observed. MDPI 2021-08-29 /pmc/articles/PMC8469108/ /pubmed/34571889 http://dx.doi.org/10.3390/cells10092240 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Ecke, Mary
Prassler, Jana
Gerisch, Günther
Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium
title Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium
title_full Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium
title_fullStr Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium
title_full_unstemmed Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium
title_short Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium
title_sort genetic instability due to spindle anomalies visualized in mutants of dictyostelium
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469108/
https://www.ncbi.nlm.nih.gov/pubmed/34571889
http://dx.doi.org/10.3390/cells10092240
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