SREBP1-Induced Glutamine Synthetase Triggers a Feedforward Loop to Upregulate SREBP1 through Sp1 O-GlcNAcylation and Augments Lipid Droplet Formation in Cancer Cells

Glutamine and lipids are two important components of proliferating cancer cells. Studies have demonstrated that glutamine synthetase (GS) boosts glutamine-dependent anabolic processes for nucleotide and protein synthesis, but the role of GS in regulating lipogenesis remains unclear. This study ident...

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Detalles Bibliográficos
Autores principales: Jhu, Jin-Wei, Yan, Jia-Bao, Lin, Zou-Han, Lin, Shih-Chieh, Peng, I-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469118/
https://www.ncbi.nlm.nih.gov/pubmed/34575972
http://dx.doi.org/10.3390/ijms22189814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469118/
https://www.ncbi.nlm.nih.gov/pubmed/34575972
http://dx.doi.org/10.3390/ijms22189814

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