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SREBP1-Induced Glutamine Synthetase Triggers a Feedforward Loop to Upregulate SREBP1 through Sp1 O-GlcNAcylation and Augments Lipid Droplet Formation in Cancer Cells
Glutamine and lipids are two important components of proliferating cancer cells. Studies have demonstrated that glutamine synthetase (GS) boosts glutamine-dependent anabolic processes for nucleotide and protein synthesis, but the role of GS in regulating lipogenesis remains unclear. This study ident...
Autores principales: | Jhu, Jin-Wei, Yan, Jia-Bao, Lin, Zou-Han, Lin, Shih-Chieh, Peng, I-Chen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469118/ https://www.ncbi.nlm.nih.gov/pubmed/34575972 http://dx.doi.org/10.3390/ijms22189814 |
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