Cargando…

Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry

The use of mesenchymal stem cells (MSCs) for regenerative purposes has become common in a large variety of diseases. In the dental and maxillofacial field, there are emerging clinical needs that could benefit from MSC-based therapeutic approaches. Even though MSCs can be isolated from different tiss...

Descripción completa

Detalles Bibliográficos
Autores principales: Roato, Ilaria, Chinigò, Giorgia, Genova, Tullio, Munaron, Luca, Mussano, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469189/
https://www.ncbi.nlm.nih.gov/pubmed/34572271
http://dx.doi.org/10.3390/biomedicines9091085
_version_ 1784573866875551744
author Roato, Ilaria
Chinigò, Giorgia
Genova, Tullio
Munaron, Luca
Mussano, Federico
author_facet Roato, Ilaria
Chinigò, Giorgia
Genova, Tullio
Munaron, Luca
Mussano, Federico
author_sort Roato, Ilaria
collection PubMed
description The use of mesenchymal stem cells (MSCs) for regenerative purposes has become common in a large variety of diseases. In the dental and maxillofacial field, there are emerging clinical needs that could benefit from MSC-based therapeutic approaches. Even though MSCs can be isolated from different tissues, such as bone marrow, adipose tissue, etc., and are known for their multilineage differentiation, their different anatomical origin can affect the capability to differentiate into a specific tissue. For instance, MSCs isolated from the oral cavity might be more effective than adipose-derived stem cells (ASCs) for the treatment of dental defects. Indeed, in the oral cavity, there are different sources of MSCs that have been individually proposed as promising candidates for tissue engineering protocols. The therapeutic strategy based on MSCs can be direct, by using cells as components of the tissue to be regenerated, or indirect, aimed at delivering local growth factors, cytokines, and chemokines produced by the MSCs. Here, the authors outline the major sources of mesenchymal stem cells attainable from the oral cavity and discuss their possible usage in some of the most compelling therapeutic frontiers, such as periodontal disease and dental pulp regeneration.
format Online
Article
Text
id pubmed-8469189
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84691892021-09-27 Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry Roato, Ilaria Chinigò, Giorgia Genova, Tullio Munaron, Luca Mussano, Federico Biomedicines Review The use of mesenchymal stem cells (MSCs) for regenerative purposes has become common in a large variety of diseases. In the dental and maxillofacial field, there are emerging clinical needs that could benefit from MSC-based therapeutic approaches. Even though MSCs can be isolated from different tissues, such as bone marrow, adipose tissue, etc., and are known for their multilineage differentiation, their different anatomical origin can affect the capability to differentiate into a specific tissue. For instance, MSCs isolated from the oral cavity might be more effective than adipose-derived stem cells (ASCs) for the treatment of dental defects. Indeed, in the oral cavity, there are different sources of MSCs that have been individually proposed as promising candidates for tissue engineering protocols. The therapeutic strategy based on MSCs can be direct, by using cells as components of the tissue to be regenerated, or indirect, aimed at delivering local growth factors, cytokines, and chemokines produced by the MSCs. Here, the authors outline the major sources of mesenchymal stem cells attainable from the oral cavity and discuss their possible usage in some of the most compelling therapeutic frontiers, such as periodontal disease and dental pulp regeneration. MDPI 2021-08-25 /pmc/articles/PMC8469189/ /pubmed/34572271 http://dx.doi.org/10.3390/biomedicines9091085 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Roato, Ilaria
Chinigò, Giorgia
Genova, Tullio
Munaron, Luca
Mussano, Federico
Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry
title Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry
title_full Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry
title_fullStr Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry
title_full_unstemmed Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry
title_short Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry
title_sort oral cavity as a source of mesenchymal stem cells useful for regenerative medicine in dentistry
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469189/
https://www.ncbi.nlm.nih.gov/pubmed/34572271
http://dx.doi.org/10.3390/biomedicines9091085
work_keys_str_mv AT roatoilaria oralcavityasasourceofmesenchymalstemcellsusefulforregenerativemedicineindentistry
AT chinigogiorgia oralcavityasasourceofmesenchymalstemcellsusefulforregenerativemedicineindentistry
AT genovatullio oralcavityasasourceofmesenchymalstemcellsusefulforregenerativemedicineindentistry
AT munaronluca oralcavityasasourceofmesenchymalstemcellsusefulforregenerativemedicineindentistry
AT mussanofederico oralcavityasasourceofmesenchymalstemcellsusefulforregenerativemedicineindentistry