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Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry
The use of mesenchymal stem cells (MSCs) for regenerative purposes has become common in a large variety of diseases. In the dental and maxillofacial field, there are emerging clinical needs that could benefit from MSC-based therapeutic approaches. Even though MSCs can be isolated from different tiss...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469189/ https://www.ncbi.nlm.nih.gov/pubmed/34572271 http://dx.doi.org/10.3390/biomedicines9091085 |
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author | Roato, Ilaria Chinigò, Giorgia Genova, Tullio Munaron, Luca Mussano, Federico |
author_facet | Roato, Ilaria Chinigò, Giorgia Genova, Tullio Munaron, Luca Mussano, Federico |
author_sort | Roato, Ilaria |
collection | PubMed |
description | The use of mesenchymal stem cells (MSCs) for regenerative purposes has become common in a large variety of diseases. In the dental and maxillofacial field, there are emerging clinical needs that could benefit from MSC-based therapeutic approaches. Even though MSCs can be isolated from different tissues, such as bone marrow, adipose tissue, etc., and are known for their multilineage differentiation, their different anatomical origin can affect the capability to differentiate into a specific tissue. For instance, MSCs isolated from the oral cavity might be more effective than adipose-derived stem cells (ASCs) for the treatment of dental defects. Indeed, in the oral cavity, there are different sources of MSCs that have been individually proposed as promising candidates for tissue engineering protocols. The therapeutic strategy based on MSCs can be direct, by using cells as components of the tissue to be regenerated, or indirect, aimed at delivering local growth factors, cytokines, and chemokines produced by the MSCs. Here, the authors outline the major sources of mesenchymal stem cells attainable from the oral cavity and discuss their possible usage in some of the most compelling therapeutic frontiers, such as periodontal disease and dental pulp regeneration. |
format | Online Article Text |
id | pubmed-8469189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84691892021-09-27 Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry Roato, Ilaria Chinigò, Giorgia Genova, Tullio Munaron, Luca Mussano, Federico Biomedicines Review The use of mesenchymal stem cells (MSCs) for regenerative purposes has become common in a large variety of diseases. In the dental and maxillofacial field, there are emerging clinical needs that could benefit from MSC-based therapeutic approaches. Even though MSCs can be isolated from different tissues, such as bone marrow, adipose tissue, etc., and are known for their multilineage differentiation, their different anatomical origin can affect the capability to differentiate into a specific tissue. For instance, MSCs isolated from the oral cavity might be more effective than adipose-derived stem cells (ASCs) for the treatment of dental defects. Indeed, in the oral cavity, there are different sources of MSCs that have been individually proposed as promising candidates for tissue engineering protocols. The therapeutic strategy based on MSCs can be direct, by using cells as components of the tissue to be regenerated, or indirect, aimed at delivering local growth factors, cytokines, and chemokines produced by the MSCs. Here, the authors outline the major sources of mesenchymal stem cells attainable from the oral cavity and discuss their possible usage in some of the most compelling therapeutic frontiers, such as periodontal disease and dental pulp regeneration. MDPI 2021-08-25 /pmc/articles/PMC8469189/ /pubmed/34572271 http://dx.doi.org/10.3390/biomedicines9091085 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Roato, Ilaria Chinigò, Giorgia Genova, Tullio Munaron, Luca Mussano, Federico Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry |
title | Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry |
title_full | Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry |
title_fullStr | Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry |
title_full_unstemmed | Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry |
title_short | Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry |
title_sort | oral cavity as a source of mesenchymal stem cells useful for regenerative medicine in dentistry |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469189/ https://www.ncbi.nlm.nih.gov/pubmed/34572271 http://dx.doi.org/10.3390/biomedicines9091085 |
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