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Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease

Background: Alzheimer’s disease (AD) is characterized by the presence of β-amyloid plaques and neurofibrillary tangles, while Lewy body dementia (LBD) is characterized by α-synuclein (α-syn) inclusions. Some authors examine α-syn protein in the neurodegeneration process of AD and propose to consider...

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Autores principales: Monge-García, Victoria, García-Ayllón, María-Salud, Sáez-Valero, Javier, Sánchez-Payá, José, Navarrete-Rueda, Francisco, Manzanares-Robles, Jorge, Gasparini-Berenguer, Ruth, Romero-Lorenzo, Raquel, Cortés-Gómez, María Angeles, Monge-Argilés, José-Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469325/
https://www.ncbi.nlm.nih.gov/pubmed/34577877
http://dx.doi.org/10.3390/medicina57090954
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author Monge-García, Victoria
García-Ayllón, María-Salud
Sáez-Valero, Javier
Sánchez-Payá, José
Navarrete-Rueda, Francisco
Manzanares-Robles, Jorge
Gasparini-Berenguer, Ruth
Romero-Lorenzo, Raquel
Cortés-Gómez, María Angeles
Monge-Argilés, José-Antonio
author_facet Monge-García, Victoria
García-Ayllón, María-Salud
Sáez-Valero, Javier
Sánchez-Payá, José
Navarrete-Rueda, Francisco
Manzanares-Robles, Jorge
Gasparini-Berenguer, Ruth
Romero-Lorenzo, Raquel
Cortés-Gómez, María Angeles
Monge-Argilés, José-Antonio
author_sort Monge-García, Victoria
collection PubMed
description Background: Alzheimer’s disease (AD) is characterized by the presence of β-amyloid plaques and neurofibrillary tangles, while Lewy body dementia (LBD) is characterized by α-synuclein (α-syn) inclusions. Some authors examine α-syn protein in the neurodegeneration process of AD and propose to consider cerebrospinal fluid (CSF) α-syn as a possible additional biomarker to the so-called “core” of AD. Objective: To determine whether there is a correlation between α-syn levels and “core” AD biomarkers in patients with mild cognitive impairment (MCI). Materials and methods: In total, 81 patients in the early stages of MCI were selected from the outpatient dementia consultation in Alicante General Hospital. Using a cross-sectional case–control design, patients were analyzed in four groups: stable MCI (MCIs; n = 25), MCI due to AD (MCI-AD; n = 32), MCI due to LBD (MCI-LBD; n = 24) and a control group of patients with acute or chronic headache (Ctrl; n = 18). Correlation between CSF protein levels in the different groups was assessed by the Rho Spearman test. Results: We found positive correlations between T-tau protein and α-syn (ρ = 0.418; p value < 0.05) and p-tau(181p) and α-syn (ρ = 0.571; p value < 0.05) exclusively in the MCI-AD group. Conclusion: The correlation found between α-syn and tau proteins in the first stages of AD support the involvement of α-syn in the pathogenesis of AD. This result may have clinical and diagnostic implications, as well as help to apply the new concept of “precision medicine” in patients with MCI.
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spelling pubmed-84693252021-09-27 Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease Monge-García, Victoria García-Ayllón, María-Salud Sáez-Valero, Javier Sánchez-Payá, José Navarrete-Rueda, Francisco Manzanares-Robles, Jorge Gasparini-Berenguer, Ruth Romero-Lorenzo, Raquel Cortés-Gómez, María Angeles Monge-Argilés, José-Antonio Medicina (Kaunas) Article Background: Alzheimer’s disease (AD) is characterized by the presence of β-amyloid plaques and neurofibrillary tangles, while Lewy body dementia (LBD) is characterized by α-synuclein (α-syn) inclusions. Some authors examine α-syn protein in the neurodegeneration process of AD and propose to consider cerebrospinal fluid (CSF) α-syn as a possible additional biomarker to the so-called “core” of AD. Objective: To determine whether there is a correlation between α-syn levels and “core” AD biomarkers in patients with mild cognitive impairment (MCI). Materials and methods: In total, 81 patients in the early stages of MCI were selected from the outpatient dementia consultation in Alicante General Hospital. Using a cross-sectional case–control design, patients were analyzed in four groups: stable MCI (MCIs; n = 25), MCI due to AD (MCI-AD; n = 32), MCI due to LBD (MCI-LBD; n = 24) and a control group of patients with acute or chronic headache (Ctrl; n = 18). Correlation between CSF protein levels in the different groups was assessed by the Rho Spearman test. Results: We found positive correlations between T-tau protein and α-syn (ρ = 0.418; p value < 0.05) and p-tau(181p) and α-syn (ρ = 0.571; p value < 0.05) exclusively in the MCI-AD group. Conclusion: The correlation found between α-syn and tau proteins in the first stages of AD support the involvement of α-syn in the pathogenesis of AD. This result may have clinical and diagnostic implications, as well as help to apply the new concept of “precision medicine” in patients with MCI. MDPI 2021-09-10 /pmc/articles/PMC8469325/ /pubmed/34577877 http://dx.doi.org/10.3390/medicina57090954 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Monge-García, Victoria
García-Ayllón, María-Salud
Sáez-Valero, Javier
Sánchez-Payá, José
Navarrete-Rueda, Francisco
Manzanares-Robles, Jorge
Gasparini-Berenguer, Ruth
Romero-Lorenzo, Raquel
Cortés-Gómez, María Angeles
Monge-Argilés, José-Antonio
Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease
title Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease
title_full Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease
title_fullStr Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease
title_full_unstemmed Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease
title_short Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease
title_sort relation between alpha-synuclein and core csf biomarkers of alzheimer’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469325/
https://www.ncbi.nlm.nih.gov/pubmed/34577877
http://dx.doi.org/10.3390/medicina57090954
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