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Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease
Background: Alzheimer’s disease (AD) is characterized by the presence of β-amyloid plaques and neurofibrillary tangles, while Lewy body dementia (LBD) is characterized by α-synuclein (α-syn) inclusions. Some authors examine α-syn protein in the neurodegeneration process of AD and propose to consider...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469325/ https://www.ncbi.nlm.nih.gov/pubmed/34577877 http://dx.doi.org/10.3390/medicina57090954 |
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author | Monge-García, Victoria García-Ayllón, María-Salud Sáez-Valero, Javier Sánchez-Payá, José Navarrete-Rueda, Francisco Manzanares-Robles, Jorge Gasparini-Berenguer, Ruth Romero-Lorenzo, Raquel Cortés-Gómez, María Angeles Monge-Argilés, José-Antonio |
author_facet | Monge-García, Victoria García-Ayllón, María-Salud Sáez-Valero, Javier Sánchez-Payá, José Navarrete-Rueda, Francisco Manzanares-Robles, Jorge Gasparini-Berenguer, Ruth Romero-Lorenzo, Raquel Cortés-Gómez, María Angeles Monge-Argilés, José-Antonio |
author_sort | Monge-García, Victoria |
collection | PubMed |
description | Background: Alzheimer’s disease (AD) is characterized by the presence of β-amyloid plaques and neurofibrillary tangles, while Lewy body dementia (LBD) is characterized by α-synuclein (α-syn) inclusions. Some authors examine α-syn protein in the neurodegeneration process of AD and propose to consider cerebrospinal fluid (CSF) α-syn as a possible additional biomarker to the so-called “core” of AD. Objective: To determine whether there is a correlation between α-syn levels and “core” AD biomarkers in patients with mild cognitive impairment (MCI). Materials and methods: In total, 81 patients in the early stages of MCI were selected from the outpatient dementia consultation in Alicante General Hospital. Using a cross-sectional case–control design, patients were analyzed in four groups: stable MCI (MCIs; n = 25), MCI due to AD (MCI-AD; n = 32), MCI due to LBD (MCI-LBD; n = 24) and a control group of patients with acute or chronic headache (Ctrl; n = 18). Correlation between CSF protein levels in the different groups was assessed by the Rho Spearman test. Results: We found positive correlations between T-tau protein and α-syn (ρ = 0.418; p value < 0.05) and p-tau(181p) and α-syn (ρ = 0.571; p value < 0.05) exclusively in the MCI-AD group. Conclusion: The correlation found between α-syn and tau proteins in the first stages of AD support the involvement of α-syn in the pathogenesis of AD. This result may have clinical and diagnostic implications, as well as help to apply the new concept of “precision medicine” in patients with MCI. |
format | Online Article Text |
id | pubmed-8469325 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84693252021-09-27 Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease Monge-García, Victoria García-Ayllón, María-Salud Sáez-Valero, Javier Sánchez-Payá, José Navarrete-Rueda, Francisco Manzanares-Robles, Jorge Gasparini-Berenguer, Ruth Romero-Lorenzo, Raquel Cortés-Gómez, María Angeles Monge-Argilés, José-Antonio Medicina (Kaunas) Article Background: Alzheimer’s disease (AD) is characterized by the presence of β-amyloid plaques and neurofibrillary tangles, while Lewy body dementia (LBD) is characterized by α-synuclein (α-syn) inclusions. Some authors examine α-syn protein in the neurodegeneration process of AD and propose to consider cerebrospinal fluid (CSF) α-syn as a possible additional biomarker to the so-called “core” of AD. Objective: To determine whether there is a correlation between α-syn levels and “core” AD biomarkers in patients with mild cognitive impairment (MCI). Materials and methods: In total, 81 patients in the early stages of MCI were selected from the outpatient dementia consultation in Alicante General Hospital. Using a cross-sectional case–control design, patients were analyzed in four groups: stable MCI (MCIs; n = 25), MCI due to AD (MCI-AD; n = 32), MCI due to LBD (MCI-LBD; n = 24) and a control group of patients with acute or chronic headache (Ctrl; n = 18). Correlation between CSF protein levels in the different groups was assessed by the Rho Spearman test. Results: We found positive correlations between T-tau protein and α-syn (ρ = 0.418; p value < 0.05) and p-tau(181p) and α-syn (ρ = 0.571; p value < 0.05) exclusively in the MCI-AD group. Conclusion: The correlation found between α-syn and tau proteins in the first stages of AD support the involvement of α-syn in the pathogenesis of AD. This result may have clinical and diagnostic implications, as well as help to apply the new concept of “precision medicine” in patients with MCI. MDPI 2021-09-10 /pmc/articles/PMC8469325/ /pubmed/34577877 http://dx.doi.org/10.3390/medicina57090954 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Monge-García, Victoria García-Ayllón, María-Salud Sáez-Valero, Javier Sánchez-Payá, José Navarrete-Rueda, Francisco Manzanares-Robles, Jorge Gasparini-Berenguer, Ruth Romero-Lorenzo, Raquel Cortés-Gómez, María Angeles Monge-Argilés, José-Antonio Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease |
title | Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease |
title_full | Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease |
title_fullStr | Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease |
title_full_unstemmed | Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease |
title_short | Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease |
title_sort | relation between alpha-synuclein and core csf biomarkers of alzheimer’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469325/ https://www.ncbi.nlm.nih.gov/pubmed/34577877 http://dx.doi.org/10.3390/medicina57090954 |
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