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Circadian Organelles: Rhythms at All Scales

Circadian clocks have evolved in most light-sensitive organisms, from unicellular organisms to mammals. Consequently, a myriad of biological functions exhibits circadian rhythmicity, from behavior to physiology, through tissue and cellular functions to subcellular processes. Circadian rhythms in int...

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Detalles Bibliográficos
Autores principales: Aviram, Rona, Adamovich, Yaarit, Asher, Gad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469338/
https://www.ncbi.nlm.nih.gov/pubmed/34572096
http://dx.doi.org/10.3390/cells10092447
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author Aviram, Rona
Adamovich, Yaarit
Asher, Gad
author_facet Aviram, Rona
Adamovich, Yaarit
Asher, Gad
author_sort Aviram, Rona
collection PubMed
description Circadian clocks have evolved in most light-sensitive organisms, from unicellular organisms to mammals. Consequently, a myriad of biological functions exhibits circadian rhythmicity, from behavior to physiology, through tissue and cellular functions to subcellular processes. Circadian rhythms in intracellular organelles are an emerging and exciting research arena. We summarize herein the current literature for rhythmicity in major intracellular organelles in mammals. These include changes in the morphology, content, and functions of different intracellular organelles. While these data highlight the presence of rhythmicity in these organelles, a gap remains in our knowledge regarding the underlying molecular mechanisms and their functional significance. Finally, we discuss the importance and challenges faced by spatio-temporal studies on these organelles and speculate on the presence of oscillators in organelles and their potential mode of communication. As circadian biology has been and continues to be studied throughout temporal and spatial axes, circadian organelles appear to be the next frontier.
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spelling pubmed-84693382021-09-27 Circadian Organelles: Rhythms at All Scales Aviram, Rona Adamovich, Yaarit Asher, Gad Cells Review Circadian clocks have evolved in most light-sensitive organisms, from unicellular organisms to mammals. Consequently, a myriad of biological functions exhibits circadian rhythmicity, from behavior to physiology, through tissue and cellular functions to subcellular processes. Circadian rhythms in intracellular organelles are an emerging and exciting research arena. We summarize herein the current literature for rhythmicity in major intracellular organelles in mammals. These include changes in the morphology, content, and functions of different intracellular organelles. While these data highlight the presence of rhythmicity in these organelles, a gap remains in our knowledge regarding the underlying molecular mechanisms and their functional significance. Finally, we discuss the importance and challenges faced by spatio-temporal studies on these organelles and speculate on the presence of oscillators in organelles and their potential mode of communication. As circadian biology has been and continues to be studied throughout temporal and spatial axes, circadian organelles appear to be the next frontier. MDPI 2021-09-16 /pmc/articles/PMC8469338/ /pubmed/34572096 http://dx.doi.org/10.3390/cells10092447 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Aviram, Rona
Adamovich, Yaarit
Asher, Gad
Circadian Organelles: Rhythms at All Scales
title Circadian Organelles: Rhythms at All Scales
title_full Circadian Organelles: Rhythms at All Scales
title_fullStr Circadian Organelles: Rhythms at All Scales
title_full_unstemmed Circadian Organelles: Rhythms at All Scales
title_short Circadian Organelles: Rhythms at All Scales
title_sort circadian organelles: rhythms at all scales
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469338/
https://www.ncbi.nlm.nih.gov/pubmed/34572096
http://dx.doi.org/10.3390/cells10092447
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