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Occupational Exposure and Multiple Myeloma Risk: An Updated Review of Meta-Analyses

The precise etiology of multiple myeloma remains elusive, but both genetic and environmental factors have been suggested to contribute to disease risk. Several occupational categories and toxic agents have been implicated as potentially causative, yet findings from the literature are inconsistent. T...

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Autores principales: Georgakopoulou, Rebecca, Fiste, Oraianthi, Sergentanis, Theodoros N., Andrikopoulou, Angeliki, Zagouri, Flora, Gavriatopoulou, Maria, Psaltopoulou, Theodora, Kastritis, Efstathios, Terpos, Evangelos, Dimopoulos, Meletios A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469366/
https://www.ncbi.nlm.nih.gov/pubmed/34575290
http://dx.doi.org/10.3390/jcm10184179
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author Georgakopoulou, Rebecca
Fiste, Oraianthi
Sergentanis, Theodoros N.
Andrikopoulou, Angeliki
Zagouri, Flora
Gavriatopoulou, Maria
Psaltopoulou, Theodora
Kastritis, Efstathios
Terpos, Evangelos
Dimopoulos, Meletios A.
author_facet Georgakopoulou, Rebecca
Fiste, Oraianthi
Sergentanis, Theodoros N.
Andrikopoulou, Angeliki
Zagouri, Flora
Gavriatopoulou, Maria
Psaltopoulou, Theodora
Kastritis, Efstathios
Terpos, Evangelos
Dimopoulos, Meletios A.
author_sort Georgakopoulou, Rebecca
collection PubMed
description The precise etiology of multiple myeloma remains elusive, but both genetic and environmental factors have been suggested to contribute to disease risk. Several occupational categories and toxic agents have been implicated as potentially causative, yet findings from the literature are inconsistent. The aim of this review was to summarize and critically comment on the accumulated epidemiological evidence, across published meta-analyses, about the association between occupational exposure and risk of multiple myeloma. Overall, results from eleven meta-epidemiological studies underscore a significantly increased risk for firefighters, hairdressers, and employees exposed to engine exhaust, whereas farming and methylene chloride exposure have been non-significantly correlated with the disease. Further epidemiological studies are of utmost importance whilst emphasis should be placed on occupational hazard surveillance, as such studies will obtain a more accurate picture of disease occurrence in working populations, and will enable both the implementation of preventive actions and the evaluation of their effectiveness.
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spelling pubmed-84693662021-09-27 Occupational Exposure and Multiple Myeloma Risk: An Updated Review of Meta-Analyses Georgakopoulou, Rebecca Fiste, Oraianthi Sergentanis, Theodoros N. Andrikopoulou, Angeliki Zagouri, Flora Gavriatopoulou, Maria Psaltopoulou, Theodora Kastritis, Efstathios Terpos, Evangelos Dimopoulos, Meletios A. J Clin Med Review The precise etiology of multiple myeloma remains elusive, but both genetic and environmental factors have been suggested to contribute to disease risk. Several occupational categories and toxic agents have been implicated as potentially causative, yet findings from the literature are inconsistent. The aim of this review was to summarize and critically comment on the accumulated epidemiological evidence, across published meta-analyses, about the association between occupational exposure and risk of multiple myeloma. Overall, results from eleven meta-epidemiological studies underscore a significantly increased risk for firefighters, hairdressers, and employees exposed to engine exhaust, whereas farming and methylene chloride exposure have been non-significantly correlated with the disease. Further epidemiological studies are of utmost importance whilst emphasis should be placed on occupational hazard surveillance, as such studies will obtain a more accurate picture of disease occurrence in working populations, and will enable both the implementation of preventive actions and the evaluation of their effectiveness. MDPI 2021-09-16 /pmc/articles/PMC8469366/ /pubmed/34575290 http://dx.doi.org/10.3390/jcm10184179 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Georgakopoulou, Rebecca
Fiste, Oraianthi
Sergentanis, Theodoros N.
Andrikopoulou, Angeliki
Zagouri, Flora
Gavriatopoulou, Maria
Psaltopoulou, Theodora
Kastritis, Efstathios
Terpos, Evangelos
Dimopoulos, Meletios A.
Occupational Exposure and Multiple Myeloma Risk: An Updated Review of Meta-Analyses
title Occupational Exposure and Multiple Myeloma Risk: An Updated Review of Meta-Analyses
title_full Occupational Exposure and Multiple Myeloma Risk: An Updated Review of Meta-Analyses
title_fullStr Occupational Exposure and Multiple Myeloma Risk: An Updated Review of Meta-Analyses
title_full_unstemmed Occupational Exposure and Multiple Myeloma Risk: An Updated Review of Meta-Analyses
title_short Occupational Exposure and Multiple Myeloma Risk: An Updated Review of Meta-Analyses
title_sort occupational exposure and multiple myeloma risk: an updated review of meta-analyses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469366/
https://www.ncbi.nlm.nih.gov/pubmed/34575290
http://dx.doi.org/10.3390/jcm10184179
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