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Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments

Solid fuel combustion is an important source of the release of rare earth elements (REEs) into the ambient environment, resulting in potential adverse effects on human cardiovascular health. Our study aimed to identify reliable exposure biomarkers of REE intake and their potential role in blood pres...

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Autores principales: Pang, Yiming, Jiang, Jianjun, Li, Kexin, Yan, Lailai, Feng, Yanqiu, Wang, Junli, Cao, Xiaolu, Li, Zhiwen, Wang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469411/
https://www.ncbi.nlm.nih.gov/pubmed/34574769
http://dx.doi.org/10.3390/ijerph18189836
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author Pang, Yiming
Jiang, Jianjun
Li, Kexin
Yan, Lailai
Feng, Yanqiu
Wang, Junli
Cao, Xiaolu
Li, Zhiwen
Wang, Bin
author_facet Pang, Yiming
Jiang, Jianjun
Li, Kexin
Yan, Lailai
Feng, Yanqiu
Wang, Junli
Cao, Xiaolu
Li, Zhiwen
Wang, Bin
author_sort Pang, Yiming
collection PubMed
description Solid fuel combustion is an important source of the release of rare earth elements (REEs) into the ambient environment, resulting in potential adverse effects on human cardiovascular health. Our study aimed to identify reliable exposure biomarkers of REE intake and their potential role in blood pressure change. A total of 24 rats were administered with 14 REE chlorides at four doses (six rats per group). Fur samples were collected both before and after administration. Blood samples were collected after 12 weeks of REE intake. The REE concentrations in rat fur and blood samples were measured by inductively coupled plasma mass spectrometry. For each week, blood pressure, as well as heart rate and pulse pressure, were measured. The linear mixed-effect model was used to analyze the relationship between REE administration dose and blood pressure change. We found that the REE concentration in fur, but not blood, samples exhibited significant dose–response relationships with administration dose. It suggested that hair samples are a more efficient matrix for indicating the exposure level of a population to REEs than blood samples. However, there was no dose–response relationships between the administration dose and blood pressure change of rats, or with heart rate and pulse pressure for the 14 REEs. We also did not find a dose–response relationship between REE administration levels and plasma concentration of 8-hydroxy-2’-deoxyguanosine, as an important DNA oxidative stress damage biomarker. In conclusion, hair samples are more suitable as a sample type to reliably assess exposure to REEs than blood samples, and REEs did not have a direct adverse effect on blood pressure in our rat model.
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spelling pubmed-84694112021-09-27 Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments Pang, Yiming Jiang, Jianjun Li, Kexin Yan, Lailai Feng, Yanqiu Wang, Junli Cao, Xiaolu Li, Zhiwen Wang, Bin Int J Environ Res Public Health Article Solid fuel combustion is an important source of the release of rare earth elements (REEs) into the ambient environment, resulting in potential adverse effects on human cardiovascular health. Our study aimed to identify reliable exposure biomarkers of REE intake and their potential role in blood pressure change. A total of 24 rats were administered with 14 REE chlorides at four doses (six rats per group). Fur samples were collected both before and after administration. Blood samples were collected after 12 weeks of REE intake. The REE concentrations in rat fur and blood samples were measured by inductively coupled plasma mass spectrometry. For each week, blood pressure, as well as heart rate and pulse pressure, were measured. The linear mixed-effect model was used to analyze the relationship between REE administration dose and blood pressure change. We found that the REE concentration in fur, but not blood, samples exhibited significant dose–response relationships with administration dose. It suggested that hair samples are a more efficient matrix for indicating the exposure level of a population to REEs than blood samples. However, there was no dose–response relationships between the administration dose and blood pressure change of rats, or with heart rate and pulse pressure for the 14 REEs. We also did not find a dose–response relationship between REE administration levels and plasma concentration of 8-hydroxy-2’-deoxyguanosine, as an important DNA oxidative stress damage biomarker. In conclusion, hair samples are more suitable as a sample type to reliably assess exposure to REEs than blood samples, and REEs did not have a direct adverse effect on blood pressure in our rat model. MDPI 2021-09-18 /pmc/articles/PMC8469411/ /pubmed/34574769 http://dx.doi.org/10.3390/ijerph18189836 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pang, Yiming
Jiang, Jianjun
Li, Kexin
Yan, Lailai
Feng, Yanqiu
Wang, Junli
Cao, Xiaolu
Li, Zhiwen
Wang, Bin
Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments
title Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments
title_full Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments
title_fullStr Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments
title_full_unstemmed Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments
title_short Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments
title_sort effects of rare earth elements on blood pressure and their exposure biomarkers: evidence from animal experiments
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469411/
https://www.ncbi.nlm.nih.gov/pubmed/34574769
http://dx.doi.org/10.3390/ijerph18189836
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