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European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe

Background. Non-polio enteroviruses (EVs) and human parechoviruses (PeVs) cause a wide range of human infections. Limited data on their true disease burden exist as standardized European-wide surveillance is lacking. Aims. Our aim is to estimate the disease burden of EV and PeV infections in Europe...

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Autores principales: Harvala, Heli, Benschop, Kimberley S. M., Berginc, Natasa, Midgley, Sofie, Wolthers, Katja, Simmonds, Peter, Feeney, Susan, Bailly, Jean-Luc, Mirand, Audrey, Fischer, Thea K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469463/
https://www.ncbi.nlm.nih.gov/pubmed/34576722
http://dx.doi.org/10.3390/microorganisms9091827
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author Harvala, Heli
Benschop, Kimberley S. M.
Berginc, Natasa
Midgley, Sofie
Wolthers, Katja
Simmonds, Peter
Feeney, Susan
Bailly, Jean-Luc
Mirand, Audrey
Fischer, Thea K.
author_facet Harvala, Heli
Benschop, Kimberley S. M.
Berginc, Natasa
Midgley, Sofie
Wolthers, Katja
Simmonds, Peter
Feeney, Susan
Bailly, Jean-Luc
Mirand, Audrey
Fischer, Thea K.
author_sort Harvala, Heli
collection PubMed
description Background. Non-polio enteroviruses (EVs) and human parechoviruses (PeVs) cause a wide range of human infections. Limited data on their true disease burden exist as standardized European-wide surveillance is lacking. Aims. Our aim is to estimate the disease burden of EV and PeV infections in Europe via establishment of standardized surveillance for hand, foot and mouth disease (HFMD) and respiratory and neurological infections caused by these viruses. We will also assess the sensitivity of assays implemented in the network of participating laboratories so that all EV and PeV types are adequately detected. Plan. The European Non-Polio Enterovirus Network (ENPEN) has developed standardized protocols for a prospective, multi-center and cross-sectional hospital-based pilot study. Protocols include guidance for diagnosis, case definition, detection, characterization and reporting of EV and PeV infections associated with HFMD and respiratory and neurological diseases. Over 30 sites from 17 European countries have already registered to this one pilot study, likely to be commenced in 2022. Benefits. This surveillance will allow European-wide comparison of data on EV and PeV infection. These data will also be used to determine the burden of EV and PeV infections, which is needed to guide the further prevention measures and policies.
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spelling pubmed-84694632021-09-27 European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe Harvala, Heli Benschop, Kimberley S. M. Berginc, Natasa Midgley, Sofie Wolthers, Katja Simmonds, Peter Feeney, Susan Bailly, Jean-Luc Mirand, Audrey Fischer, Thea K. Microorganisms Article Background. Non-polio enteroviruses (EVs) and human parechoviruses (PeVs) cause a wide range of human infections. Limited data on their true disease burden exist as standardized European-wide surveillance is lacking. Aims. Our aim is to estimate the disease burden of EV and PeV infections in Europe via establishment of standardized surveillance for hand, foot and mouth disease (HFMD) and respiratory and neurological infections caused by these viruses. We will also assess the sensitivity of assays implemented in the network of participating laboratories so that all EV and PeV types are adequately detected. Plan. The European Non-Polio Enterovirus Network (ENPEN) has developed standardized protocols for a prospective, multi-center and cross-sectional hospital-based pilot study. Protocols include guidance for diagnosis, case definition, detection, characterization and reporting of EV and PeV infections associated with HFMD and respiratory and neurological diseases. Over 30 sites from 17 European countries have already registered to this one pilot study, likely to be commenced in 2022. Benefits. This surveillance will allow European-wide comparison of data on EV and PeV infection. These data will also be used to determine the burden of EV and PeV infections, which is needed to guide the further prevention measures and policies. MDPI 2021-08-27 /pmc/articles/PMC8469463/ /pubmed/34576722 http://dx.doi.org/10.3390/microorganisms9091827 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Harvala, Heli
Benschop, Kimberley S. M.
Berginc, Natasa
Midgley, Sofie
Wolthers, Katja
Simmonds, Peter
Feeney, Susan
Bailly, Jean-Luc
Mirand, Audrey
Fischer, Thea K.
European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe
title European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe
title_full European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe
title_fullStr European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe
title_full_unstemmed European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe
title_short European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe
title_sort european non-polio enterovirus network: introduction of hospital-based surveillance network to understand the true disease burden of non-polio enterovirus and parechovirus infections in europe
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469463/
https://www.ncbi.nlm.nih.gov/pubmed/34576722
http://dx.doi.org/10.3390/microorganisms9091827
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