Cargando…

Assessment of Body Composition as an Indicator of Early Peripheral Parenteral Nutrition Therapy in Patients Undergoing Colorectal Cancer Surgery in an Enhanced Recovery Program

Background: A poor body composition (BC) has been identified as a risk factor for patients with colorectal cancer (CRC). This study was performed to assess the effect of early peripheral parenteral nutrition (PPN) on BC in patients undergoing CCR surgery within an enhanced recovery program. Methods:...

Descripción completa

Detalles Bibliográficos
Autores principales: López-Rodríguez-Arias, Francisco, Sánchez-Guillén, Luis, Lillo-García, Cristina, Aranaz-Ostáriz, Verónica, Alcaide, M José, Soler-Silva, Álvaro, Soriano-Irigaray, Leticia, Barber, Xavier, Arroyo, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469550/
https://www.ncbi.nlm.nih.gov/pubmed/34579122
http://dx.doi.org/10.3390/nu13093245
_version_ 1784573961471787008
author López-Rodríguez-Arias, Francisco
Sánchez-Guillén, Luis
Lillo-García, Cristina
Aranaz-Ostáriz, Verónica
Alcaide, M José
Soler-Silva, Álvaro
Soriano-Irigaray, Leticia
Barber, Xavier
Arroyo, Antonio
author_facet López-Rodríguez-Arias, Francisco
Sánchez-Guillén, Luis
Lillo-García, Cristina
Aranaz-Ostáriz, Verónica
Alcaide, M José
Soler-Silva, Álvaro
Soriano-Irigaray, Leticia
Barber, Xavier
Arroyo, Antonio
author_sort López-Rodríguez-Arias, Francisco
collection PubMed
description Background: A poor body composition (BC) has been identified as a risk factor for patients with colorectal cancer (CRC). This study was performed to assess the effect of early peripheral parenteral nutrition (PPN) on BC in patients undergoing CCR surgery within an enhanced recovery program. Methods: Patients with normal nutritional status were prospectively included between October 2016 and September 2019, randomized into two groups (PPN with periOlimel N4-E versus conventional fluid therapy) and subsequently classified according to their preoperative CT scan into high- or low-risk BC groups. Postoperative complications and length of hospital stay (LOS) were assessed. Results: Of the 156 patients analyzed, 88 patients (56.4%) were classified as having high-risk BC according to CT measurements. PPN led to a 15.4% reduction in postoperative complications in high-risk vs. 1.7% in low-risk BC patients. In the multivariate analysis, high-risk BC was related to an OR (95% CI) of 2 (p = 0.044) of presenting complications and of 1.9 (p = 0.066) for major complications, and was associated with an increase in LOS of 3.6 days (p = 0.039). Conclusions: The measurement of patients’ BC can allow for the identification of target patients where PPN has been proven to be an effective tool to improve postoperative outcomes.
format Online
Article
Text
id pubmed-8469550
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84695502021-09-27 Assessment of Body Composition as an Indicator of Early Peripheral Parenteral Nutrition Therapy in Patients Undergoing Colorectal Cancer Surgery in an Enhanced Recovery Program López-Rodríguez-Arias, Francisco Sánchez-Guillén, Luis Lillo-García, Cristina Aranaz-Ostáriz, Verónica Alcaide, M José Soler-Silva, Álvaro Soriano-Irigaray, Leticia Barber, Xavier Arroyo, Antonio Nutrients Article Background: A poor body composition (BC) has been identified as a risk factor for patients with colorectal cancer (CRC). This study was performed to assess the effect of early peripheral parenteral nutrition (PPN) on BC in patients undergoing CCR surgery within an enhanced recovery program. Methods: Patients with normal nutritional status were prospectively included between October 2016 and September 2019, randomized into two groups (PPN with periOlimel N4-E versus conventional fluid therapy) and subsequently classified according to their preoperative CT scan into high- or low-risk BC groups. Postoperative complications and length of hospital stay (LOS) were assessed. Results: Of the 156 patients analyzed, 88 patients (56.4%) were classified as having high-risk BC according to CT measurements. PPN led to a 15.4% reduction in postoperative complications in high-risk vs. 1.7% in low-risk BC patients. In the multivariate analysis, high-risk BC was related to an OR (95% CI) of 2 (p = 0.044) of presenting complications and of 1.9 (p = 0.066) for major complications, and was associated with an increase in LOS of 3.6 days (p = 0.039). Conclusions: The measurement of patients’ BC can allow for the identification of target patients where PPN has been proven to be an effective tool to improve postoperative outcomes. MDPI 2021-09-18 /pmc/articles/PMC8469550/ /pubmed/34579122 http://dx.doi.org/10.3390/nu13093245 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
López-Rodríguez-Arias, Francisco
Sánchez-Guillén, Luis
Lillo-García, Cristina
Aranaz-Ostáriz, Verónica
Alcaide, M José
Soler-Silva, Álvaro
Soriano-Irigaray, Leticia
Barber, Xavier
Arroyo, Antonio
Assessment of Body Composition as an Indicator of Early Peripheral Parenteral Nutrition Therapy in Patients Undergoing Colorectal Cancer Surgery in an Enhanced Recovery Program
title Assessment of Body Composition as an Indicator of Early Peripheral Parenteral Nutrition Therapy in Patients Undergoing Colorectal Cancer Surgery in an Enhanced Recovery Program
title_full Assessment of Body Composition as an Indicator of Early Peripheral Parenteral Nutrition Therapy in Patients Undergoing Colorectal Cancer Surgery in an Enhanced Recovery Program
title_fullStr Assessment of Body Composition as an Indicator of Early Peripheral Parenteral Nutrition Therapy in Patients Undergoing Colorectal Cancer Surgery in an Enhanced Recovery Program
title_full_unstemmed Assessment of Body Composition as an Indicator of Early Peripheral Parenteral Nutrition Therapy in Patients Undergoing Colorectal Cancer Surgery in an Enhanced Recovery Program
title_short Assessment of Body Composition as an Indicator of Early Peripheral Parenteral Nutrition Therapy in Patients Undergoing Colorectal Cancer Surgery in an Enhanced Recovery Program
title_sort assessment of body composition as an indicator of early peripheral parenteral nutrition therapy in patients undergoing colorectal cancer surgery in an enhanced recovery program
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469550/
https://www.ncbi.nlm.nih.gov/pubmed/34579122
http://dx.doi.org/10.3390/nu13093245
work_keys_str_mv AT lopezrodriguezariasfrancisco assessmentofbodycompositionasanindicatorofearlyperipheralparenteralnutritiontherapyinpatientsundergoingcolorectalcancersurgeryinanenhancedrecoveryprogram
AT sanchezguillenluis assessmentofbodycompositionasanindicatorofearlyperipheralparenteralnutritiontherapyinpatientsundergoingcolorectalcancersurgeryinanenhancedrecoveryprogram
AT lillogarciacristina assessmentofbodycompositionasanindicatorofearlyperipheralparenteralnutritiontherapyinpatientsundergoingcolorectalcancersurgeryinanenhancedrecoveryprogram
AT aranazostarizveronica assessmentofbodycompositionasanindicatorofearlyperipheralparenteralnutritiontherapyinpatientsundergoingcolorectalcancersurgeryinanenhancedrecoveryprogram
AT alcaidemjose assessmentofbodycompositionasanindicatorofearlyperipheralparenteralnutritiontherapyinpatientsundergoingcolorectalcancersurgeryinanenhancedrecoveryprogram
AT solersilvaalvaro assessmentofbodycompositionasanindicatorofearlyperipheralparenteralnutritiontherapyinpatientsundergoingcolorectalcancersurgeryinanenhancedrecoveryprogram
AT sorianoirigarayleticia assessmentofbodycompositionasanindicatorofearlyperipheralparenteralnutritiontherapyinpatientsundergoingcolorectalcancersurgeryinanenhancedrecoveryprogram
AT barberxavier assessmentofbodycompositionasanindicatorofearlyperipheralparenteralnutritiontherapyinpatientsundergoingcolorectalcancersurgeryinanenhancedrecoveryprogram
AT arroyoantonio assessmentofbodycompositionasanindicatorofearlyperipheralparenteralnutritiontherapyinpatientsundergoingcolorectalcancersurgeryinanenhancedrecoveryprogram