Cargando…
Interactions of Globular and Ribbon [γ4E]GID with α4β2 Neuronal Nicotinic Acetylcholine Receptor
The α4β2 nAChR is implicated in a range of diseases and disorders including nicotine addiction, epilepsy and Parkinson’s and Alzheimer’s diseases. Designing α4β2 nAChR selective inhibitors could help define the role of the α4β2 nAChR in such disease states. In this study, we aimed to modify globular...
Autores principales: | Wu, Xiaosa, Craik, David J., Kaas, Quentin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469569/ https://www.ncbi.nlm.nih.gov/pubmed/34564144 http://dx.doi.org/10.3390/md19090482 |
Ejemplares similares
-
Ribbon α-Conotoxin KTM Exhibits Potent Inhibition of Nicotinic Acetylcholine Receptors
por: Marquart, Leanna A., et al.
Publicado: (2019) -
Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation – Suggestion of a Binding Mode at the α7 nAChR
por: El Hamdaoui, Yamina, et al.
Publicado: (2019) -
Single-channel properties of α3β4, α3β4α5 and α3β4β2 nicotinic acetylcholine receptors in mice lacking specific nicotinic acetylcholine receptor subunits
por: Ciuraszkiewicz, Anna, et al.
Publicado: (2013) -
Identification of a Negative Allosteric Site on Human α4β2 and α3β4 Neuronal Nicotinic Acetylcholine Receptors
por: Pavlovicz, Ryan E., et al.
Publicado: (2011) -
Role of Cys(I)–Cys(III) Disulfide
Bond on the Structure and Activity of α-Conotoxins at
Human Neuronal Nicotinic Acetylcholine Receptors
por: Tabassum, Nargis, et al.
Publicado: (2017)