Trimeric and Dimeric Carbazole Alkaloids from Murraya microphylla

Seventeen new carbazole alkaloid derivatives, including a trimeric carbazole racemate, (±)-microphyltrine A (1), 15 dimeric carbazole racemates, (±)-microphyldines A–O (2–16), and a C-6–C-3″-methyl-linked dimeric carbazole, microphyldine P (17), were isolated from the leaves and stems of Murraya mic...

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Autores principales: Ma, Xiaoli, Chen, Hongwei, Zhu, Sisi, Tu, Pengfei, Jiang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469674/
https://www.ncbi.nlm.nih.gov/pubmed/34577160
http://dx.doi.org/10.3390/molecules26185689
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author Ma, Xiaoli
Chen, Hongwei
Zhu, Sisi
Tu, Pengfei
Jiang, Yong
author_facet Ma, Xiaoli
Chen, Hongwei
Zhu, Sisi
Tu, Pengfei
Jiang, Yong
author_sort Ma, Xiaoli
collection PubMed
description Seventeen new carbazole alkaloid derivatives, including a trimeric carbazole racemate, (±)-microphyltrine A (1), 15 dimeric carbazole racemates, (±)-microphyldines A–O (2–16), and a C-6–C-3″-methyl-linked dimeric carbazole, microphyldine P (17), were isolated from the leaves and stems of Murraya microphylla (Merr. et Chun) Swingle. The structures of the new compounds were elucidated on the basis of HRESIMS and NMR data analysis. The optically pure isomers of these isolated carbazole alkaloids were obtained by chiral HPLC separation and their absolute configurations were determined by electronic circular dichroism (ECD) data analysis.
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spelling pubmed-84696742021-09-27 Trimeric and Dimeric Carbazole Alkaloids from Murraya microphylla Ma, Xiaoli Chen, Hongwei Zhu, Sisi Tu, Pengfei Jiang, Yong Molecules Article Seventeen new carbazole alkaloid derivatives, including a trimeric carbazole racemate, (±)-microphyltrine A (1), 15 dimeric carbazole racemates, (±)-microphyldines A–O (2–16), and a C-6–C-3″-methyl-linked dimeric carbazole, microphyldine P (17), were isolated from the leaves and stems of Murraya microphylla (Merr. et Chun) Swingle. The structures of the new compounds were elucidated on the basis of HRESIMS and NMR data analysis. The optically pure isomers of these isolated carbazole alkaloids were obtained by chiral HPLC separation and their absolute configurations were determined by electronic circular dichroism (ECD) data analysis. MDPI 2021-09-20 /pmc/articles/PMC8469674/ /pubmed/34577160 http://dx.doi.org/10.3390/molecules26185689 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ma, Xiaoli
Chen, Hongwei
Zhu, Sisi
Tu, Pengfei
Jiang, Yong
Trimeric and Dimeric Carbazole Alkaloids from Murraya microphylla
title Trimeric and Dimeric Carbazole Alkaloids from Murraya microphylla
title_full Trimeric and Dimeric Carbazole Alkaloids from Murraya microphylla
title_fullStr Trimeric and Dimeric Carbazole Alkaloids from Murraya microphylla
title_full_unstemmed Trimeric and Dimeric Carbazole Alkaloids from Murraya microphylla
title_short Trimeric and Dimeric Carbazole Alkaloids from Murraya microphylla
title_sort trimeric and dimeric carbazole alkaloids from murraya microphylla
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469674/
https://www.ncbi.nlm.nih.gov/pubmed/34577160
http://dx.doi.org/10.3390/molecules26185689
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AT tupengfei trimericanddimericcarbazolealkaloidsfrommurrayamicrophylla
AT jiangyong trimericanddimericcarbazolealkaloidsfrommurrayamicrophylla

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