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Deciphering Structural Alterations Associated with Activity Reductions of Genetic Polymorphisms in Cytochrome P450 2A6 Using Molecular Dynamics Simulations

Cytochrome P450 (CYP) 2A6 is a monooxygenase involved in the metabolism of various endogenous and exogenous chemicals, such as nicotine and therapeutic drugs. The genetic polymorphisms in CYP2A6 are a cause of individual variation in smoking behavior and drug toxicities. The enzymatic activities of...

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Detalles Bibliográficos
Autores principales:	Kato, Koichi, Nakayoshi, Tomoki, Nokura, Rika, Hosono, Hiroki, Hiratsuka, Masahiro, Ishikawa, Yoshinobu, Kurimoto, Eiji, Oda, Akifumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469730/ https://www.ncbi.nlm.nih.gov/pubmed/34576282 http://dx.doi.org/10.3390/ijms221810119

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