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The GluN2B-Selective Antagonist Ro 25-6981 Is Effective against PTZ-Induced Seizures and Safe for Further Development in Infantile Rats

The GluN2B subunit of NMDA receptors represents a perspective therapeutic target in various CNS pathologies, including epilepsy. Because of its predominant expression in the immature brain, selective GluN2B antagonists are expected to be more effective early in postnatal development. The aim of this...

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Detalles Bibliográficos
Autores principales:	Mareš, Pavel, Kozlová, Lucie, Mikulecká, Anna, Kubová, Hana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469742/ https://www.ncbi.nlm.nih.gov/pubmed/34575558 http://dx.doi.org/10.3390/pharmaceutics13091482

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