Pediatric Mixed-Phenotype Acute Leukemia: What’s New?

SIMPLE SUMMARY: Pediatric mixed-phenotype leukemia is a rare form of blood cancer in children. In this review, we cover both the evolution of treatment over the past several years and outline new emerging concepts in this disease. ABSTRACT: Mixed-phenotype acute leukemias (MPAL) are rare in children...

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Autores principales: Batra, Sandeep, Ross, Anthony John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469808/
https://www.ncbi.nlm.nih.gov/pubmed/34572885
http://dx.doi.org/10.3390/cancers13184658
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author Batra, Sandeep
Ross, Anthony John
author_facet Batra, Sandeep
Ross, Anthony John
author_sort Batra, Sandeep
collection PubMed
description SIMPLE SUMMARY: Pediatric mixed-phenotype leukemia is a rare form of blood cancer in children. In this review, we cover both the evolution of treatment over the past several years and outline new emerging concepts in this disease. ABSTRACT: Mixed-phenotype acute leukemias (MPAL) are rare in children and often lack consensus on optimal management. This review examines the current controversies and emerging paradigms in the management of pediatric MPAL. We examine risk stratification, outcomes of recent retrospective and prospective collaborative trials, and the role of transplantation and precision genomics, and outline emerging targets and concepts in this rare entity.
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spelling pubmed-84698082021-09-27 Pediatric Mixed-Phenotype Acute Leukemia: What’s New? Batra, Sandeep Ross, Anthony John Cancers (Basel) Review SIMPLE SUMMARY: Pediatric mixed-phenotype leukemia is a rare form of blood cancer in children. In this review, we cover both the evolution of treatment over the past several years and outline new emerging concepts in this disease. ABSTRACT: Mixed-phenotype acute leukemias (MPAL) are rare in children and often lack consensus on optimal management. This review examines the current controversies and emerging paradigms in the management of pediatric MPAL. We examine risk stratification, outcomes of recent retrospective and prospective collaborative trials, and the role of transplantation and precision genomics, and outline emerging targets and concepts in this rare entity. MDPI 2021-09-16 /pmc/articles/PMC8469808/ /pubmed/34572885 http://dx.doi.org/10.3390/cancers13184658 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Batra, Sandeep
Ross, Anthony John
Pediatric Mixed-Phenotype Acute Leukemia: What’s New?
title Pediatric Mixed-Phenotype Acute Leukemia: What’s New?
title_full Pediatric Mixed-Phenotype Acute Leukemia: What’s New?
title_fullStr Pediatric Mixed-Phenotype Acute Leukemia: What’s New?
title_full_unstemmed Pediatric Mixed-Phenotype Acute Leukemia: What’s New?
title_short Pediatric Mixed-Phenotype Acute Leukemia: What’s New?
title_sort pediatric mixed-phenotype acute leukemia: what’s new?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469808/
https://www.ncbi.nlm.nih.gov/pubmed/34572885
http://dx.doi.org/10.3390/cancers13184658
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AT rossanthonyjohn pediatricmixedphenotypeacuteleukemiawhatsnew

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