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Sex Differences in Dopamine Receptors and Relevance to Neuropsychiatric Disorders

Dopamine is an important neurotransmitter that plays a key role in neuropsychiatric illness. Sex differences in dopaminergic signaling have been acknowledged for decades and have been linked to sex-specific heterogeneity in both dopamine-related behaviours as well as in various neuropsychiatric diso...

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Autores principales: Williams, Olivia O. F., Coppolino, Madeleine, George, Susan R., Perreault, Melissa L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469878/
https://www.ncbi.nlm.nih.gov/pubmed/34573220
http://dx.doi.org/10.3390/brainsci11091199
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author Williams, Olivia O. F.
Coppolino, Madeleine
George, Susan R.
Perreault, Melissa L.
author_facet Williams, Olivia O. F.
Coppolino, Madeleine
George, Susan R.
Perreault, Melissa L.
author_sort Williams, Olivia O. F.
collection PubMed
description Dopamine is an important neurotransmitter that plays a key role in neuropsychiatric illness. Sex differences in dopaminergic signaling have been acknowledged for decades and have been linked to sex-specific heterogeneity in both dopamine-related behaviours as well as in various neuropsychiatric disorders. However, the overall number of studies that have evaluated sex differences in dopamine signaling, both in health and in these disorders, is low. This review will bring together what is known regarding sex differences in innate dopamine receptor expression and function, as well as highlight the known sex-specific roles of dopamine in addiction, depression, anxiety, schizophrenia, and attention deficit hyperactivity disorder. Due to differences in prognosis, diagnosis, and symptomatology between male and female subjects in disorders that involve dopamine signaling, or in responses that utilize pharmacological interventions that target dopamine receptors, understanding the fundamental sex differences in dopamine receptors is of vital importance for the personalization of therapeutic treatment strategies.
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spelling pubmed-84698782021-09-27 Sex Differences in Dopamine Receptors and Relevance to Neuropsychiatric Disorders Williams, Olivia O. F. Coppolino, Madeleine George, Susan R. Perreault, Melissa L. Brain Sci Review Dopamine is an important neurotransmitter that plays a key role in neuropsychiatric illness. Sex differences in dopaminergic signaling have been acknowledged for decades and have been linked to sex-specific heterogeneity in both dopamine-related behaviours as well as in various neuropsychiatric disorders. However, the overall number of studies that have evaluated sex differences in dopamine signaling, both in health and in these disorders, is low. This review will bring together what is known regarding sex differences in innate dopamine receptor expression and function, as well as highlight the known sex-specific roles of dopamine in addiction, depression, anxiety, schizophrenia, and attention deficit hyperactivity disorder. Due to differences in prognosis, diagnosis, and symptomatology between male and female subjects in disorders that involve dopamine signaling, or in responses that utilize pharmacological interventions that target dopamine receptors, understanding the fundamental sex differences in dopamine receptors is of vital importance for the personalization of therapeutic treatment strategies. MDPI 2021-09-11 /pmc/articles/PMC8469878/ /pubmed/34573220 http://dx.doi.org/10.3390/brainsci11091199 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Williams, Olivia O. F.
Coppolino, Madeleine
George, Susan R.
Perreault, Melissa L.
Sex Differences in Dopamine Receptors and Relevance to Neuropsychiatric Disorders
title Sex Differences in Dopamine Receptors and Relevance to Neuropsychiatric Disorders
title_full Sex Differences in Dopamine Receptors and Relevance to Neuropsychiatric Disorders
title_fullStr Sex Differences in Dopamine Receptors and Relevance to Neuropsychiatric Disorders
title_full_unstemmed Sex Differences in Dopamine Receptors and Relevance to Neuropsychiatric Disorders
title_short Sex Differences in Dopamine Receptors and Relevance to Neuropsychiatric Disorders
title_sort sex differences in dopamine receptors and relevance to neuropsychiatric disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469878/
https://www.ncbi.nlm.nih.gov/pubmed/34573220
http://dx.doi.org/10.3390/brainsci11091199
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