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Involvement of Angiogenesis in the Pathogenesis of Coronary Aneurysms
The present study aimed to evaluate the plasma concentration of pro and antiangiogenic factors and their role in the pathogenesis of coronary artery abnormal dilation (CAAD). We measured the plasma concentration of matrix metalloproteinase-8 (MMP-8), transforming growth factor beta 1 (TGF-β1), Angio...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469881/ https://www.ncbi.nlm.nih.gov/pubmed/34572455 http://dx.doi.org/10.3390/biomedicines9091269 |
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author | Iwańczyk, Sylwia Lehmann, Tomasz Cieślewicz, Artur Radziemski, Artur Malesza, Katarzyna Wrotyński, Michał Jagodziński, Paweł Piotr Grygier, Marek Lesiak, Maciej Araszkiewicz, Aleksander |
author_facet | Iwańczyk, Sylwia Lehmann, Tomasz Cieślewicz, Artur Radziemski, Artur Malesza, Katarzyna Wrotyński, Michał Jagodziński, Paweł Piotr Grygier, Marek Lesiak, Maciej Araszkiewicz, Aleksander |
author_sort | Iwańczyk, Sylwia |
collection | PubMed |
description | The present study aimed to evaluate the plasma concentration of pro and antiangiogenic factors and their role in the pathogenesis of coronary artery abnormal dilation (CAAD). We measured the plasma concentration of matrix metalloproteinase-8 (MMP-8), transforming growth factor beta 1 (TGF-β1), Angiopoietin-2, vascular endothelial growth factor (VEGF), and fibroblast growth factor (FGF) using a sandwich ELISA technique in the plasma of patients with coronary artery abnormal dilation (CAAD, Group 1), coronary artery disease (CAD, Group 2), and normal coronary arteries (NCA, Group 3). Patients suffering from CAAD showed significantly higher plasma concentrations of VEGF (p = 0.002) than those from the control group. Both pathological angiogenesis and inflammation appear to be crucial in the pathogenesis of aneurysmal dilatation of the coronary arteries. |
format | Online Article Text |
id | pubmed-8469881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84698812021-09-27 Involvement of Angiogenesis in the Pathogenesis of Coronary Aneurysms Iwańczyk, Sylwia Lehmann, Tomasz Cieślewicz, Artur Radziemski, Artur Malesza, Katarzyna Wrotyński, Michał Jagodziński, Paweł Piotr Grygier, Marek Lesiak, Maciej Araszkiewicz, Aleksander Biomedicines Article The present study aimed to evaluate the plasma concentration of pro and antiangiogenic factors and their role in the pathogenesis of coronary artery abnormal dilation (CAAD). We measured the plasma concentration of matrix metalloproteinase-8 (MMP-8), transforming growth factor beta 1 (TGF-β1), Angiopoietin-2, vascular endothelial growth factor (VEGF), and fibroblast growth factor (FGF) using a sandwich ELISA technique in the plasma of patients with coronary artery abnormal dilation (CAAD, Group 1), coronary artery disease (CAD, Group 2), and normal coronary arteries (NCA, Group 3). Patients suffering from CAAD showed significantly higher plasma concentrations of VEGF (p = 0.002) than those from the control group. Both pathological angiogenesis and inflammation appear to be crucial in the pathogenesis of aneurysmal dilatation of the coronary arteries. MDPI 2021-09-19 /pmc/articles/PMC8469881/ /pubmed/34572455 http://dx.doi.org/10.3390/biomedicines9091269 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Iwańczyk, Sylwia Lehmann, Tomasz Cieślewicz, Artur Radziemski, Artur Malesza, Katarzyna Wrotyński, Michał Jagodziński, Paweł Piotr Grygier, Marek Lesiak, Maciej Araszkiewicz, Aleksander Involvement of Angiogenesis in the Pathogenesis of Coronary Aneurysms |
title | Involvement of Angiogenesis in the Pathogenesis of Coronary Aneurysms |
title_full | Involvement of Angiogenesis in the Pathogenesis of Coronary Aneurysms |
title_fullStr | Involvement of Angiogenesis in the Pathogenesis of Coronary Aneurysms |
title_full_unstemmed | Involvement of Angiogenesis in the Pathogenesis of Coronary Aneurysms |
title_short | Involvement of Angiogenesis in the Pathogenesis of Coronary Aneurysms |
title_sort | involvement of angiogenesis in the pathogenesis of coronary aneurysms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469881/ https://www.ncbi.nlm.nih.gov/pubmed/34572455 http://dx.doi.org/10.3390/biomedicines9091269 |
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