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Percutaneous Core Needle Biopsy Can Efficiently and Safely Diagnose Most Primary Bone Tumors

A biopsy is a prerequisite for the diagnosis and evaluation of musculoskeletal tumors. It is considered that surgical biopsy provides a more reliable diagnosis because it can obtain more tumor material for pathological analysis. However, it is often associated with a significant complication rate. I...

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Autores principales: Crenn, Vincent, Vezole, Léonard, Bouhamama, Amine, Meurgey, Alexandra, Karanian, Marie, Marec-Bérard, Perrine, Gouin, François, Vaz, Gualter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469906/
https://www.ncbi.nlm.nih.gov/pubmed/34573895
http://dx.doi.org/10.3390/diagnostics11091552
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author Crenn, Vincent
Vezole, Léonard
Bouhamama, Amine
Meurgey, Alexandra
Karanian, Marie
Marec-Bérard, Perrine
Gouin, François
Vaz, Gualter
author_facet Crenn, Vincent
Vezole, Léonard
Bouhamama, Amine
Meurgey, Alexandra
Karanian, Marie
Marec-Bérard, Perrine
Gouin, François
Vaz, Gualter
author_sort Crenn, Vincent
collection PubMed
description A biopsy is a prerequisite for the diagnosis and evaluation of musculoskeletal tumors. It is considered that surgical biopsy provides a more reliable diagnosis because it can obtain more tumor material for pathological analysis. However, it is often associated with a significant complication rate. Imaging-guided percutaneous core needle biopsy (PCNB) is now widely used as an alternative to surgical biopsy; it appears to be minimally invasive, possibly with lower complication rates. This study evaluates the diagnostic yield of the preferred use of PCNB in a referral center, its accuracy, and its complication rate. The data relating to the biopsy and the histological analysis were extracted from the database of a bone tumor reference center where PCNB of bone tumors was discussed as a first-line option. 196 bone tumors were biopsied percutaneously between 2016 and 2020. They were located in the axial skeleton in 21.4% (42) of cases, in the lower limb in 58.7% (115), and in the upper limb in 19.9% (39) cases. We obtained a diagnosis yield of 84.7% and a diagnosis accuracy of 91.7%. The overall complication rate of the percutaneous biopsies observed was 1.0% (n = 2), consisting of two hematomas. PCNB performed in a referral center is a safe, precise procedure, with a very low complication rate, and which avoids the need for first-line open surgical biopsy. The consultation between pathologist, radiologist, and clinician in an expert reference center makes this technique an effective choice as a first-line diagnosis tool.
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spelling pubmed-84699062021-09-27 Percutaneous Core Needle Biopsy Can Efficiently and Safely Diagnose Most Primary Bone Tumors Crenn, Vincent Vezole, Léonard Bouhamama, Amine Meurgey, Alexandra Karanian, Marie Marec-Bérard, Perrine Gouin, François Vaz, Gualter Diagnostics (Basel) Article A biopsy is a prerequisite for the diagnosis and evaluation of musculoskeletal tumors. It is considered that surgical biopsy provides a more reliable diagnosis because it can obtain more tumor material for pathological analysis. However, it is often associated with a significant complication rate. Imaging-guided percutaneous core needle biopsy (PCNB) is now widely used as an alternative to surgical biopsy; it appears to be minimally invasive, possibly with lower complication rates. This study evaluates the diagnostic yield of the preferred use of PCNB in a referral center, its accuracy, and its complication rate. The data relating to the biopsy and the histological analysis were extracted from the database of a bone tumor reference center where PCNB of bone tumors was discussed as a first-line option. 196 bone tumors were biopsied percutaneously between 2016 and 2020. They were located in the axial skeleton in 21.4% (42) of cases, in the lower limb in 58.7% (115), and in the upper limb in 19.9% (39) cases. We obtained a diagnosis yield of 84.7% and a diagnosis accuracy of 91.7%. The overall complication rate of the percutaneous biopsies observed was 1.0% (n = 2), consisting of two hematomas. PCNB performed in a referral center is a safe, precise procedure, with a very low complication rate, and which avoids the need for first-line open surgical biopsy. The consultation between pathologist, radiologist, and clinician in an expert reference center makes this technique an effective choice as a first-line diagnosis tool. MDPI 2021-08-27 /pmc/articles/PMC8469906/ /pubmed/34573895 http://dx.doi.org/10.3390/diagnostics11091552 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Crenn, Vincent
Vezole, Léonard
Bouhamama, Amine
Meurgey, Alexandra
Karanian, Marie
Marec-Bérard, Perrine
Gouin, François
Vaz, Gualter
Percutaneous Core Needle Biopsy Can Efficiently and Safely Diagnose Most Primary Bone Tumors
title Percutaneous Core Needle Biopsy Can Efficiently and Safely Diagnose Most Primary Bone Tumors
title_full Percutaneous Core Needle Biopsy Can Efficiently and Safely Diagnose Most Primary Bone Tumors
title_fullStr Percutaneous Core Needle Biopsy Can Efficiently and Safely Diagnose Most Primary Bone Tumors
title_full_unstemmed Percutaneous Core Needle Biopsy Can Efficiently and Safely Diagnose Most Primary Bone Tumors
title_short Percutaneous Core Needle Biopsy Can Efficiently and Safely Diagnose Most Primary Bone Tumors
title_sort percutaneous core needle biopsy can efficiently and safely diagnose most primary bone tumors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469906/
https://www.ncbi.nlm.nih.gov/pubmed/34573895
http://dx.doi.org/10.3390/diagnostics11091552
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