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Accelerated Wound Healing Using a Novel Far-Infrared Ceramic Blanket

Introduction: Wounds are associated with ranges of simple to complex disruption or damage to anatomical structure and function. They are also associated with enormous economic and social costs, increasing yearly, resulting in a severe impact on the wellbeing of individuals and society. Technology th...

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Autores principales: Carrick, Frederick Robert, Valerio, Luis Sebastian Alexis, Gonzalez-Vega, Maxine N., Engel, David, Sugaya, Kiminobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469926/
https://www.ncbi.nlm.nih.gov/pubmed/34575027
http://dx.doi.org/10.3390/life11090878
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author Carrick, Frederick Robert
Valerio, Luis Sebastian Alexis
Gonzalez-Vega, Maxine N.
Engel, David
Sugaya, Kiminobu
author_facet Carrick, Frederick Robert
Valerio, Luis Sebastian Alexis
Gonzalez-Vega, Maxine N.
Engel, David
Sugaya, Kiminobu
author_sort Carrick, Frederick Robert
collection PubMed
description Introduction: Wounds are associated with ranges of simple to complex disruption or damage to anatomical structure and function. They are also associated with enormous economic and social costs, increasing yearly, resulting in a severe impact on the wellbeing of individuals and society. Technology that might accelerate wound healing is associated with many benefits to injured people. Methods: BALBc mice underwent symmetrical excisional wounds through the panniculus carnosus. They were divided into a treatment group placed on an autonomous ceramic far-field infrared blanket (cIFRB) and a control group maintained under standard conditions. We also expanded and cultured adipose tissue-derived mesenchymal stem cells (MSCs) on cIFRB and compared them to standard conditions subjected to a scratch injury to compare survival, proliferation, and wound healing. Results: The wound healing of the cIRFB treatment group was significantly faster than the control group of mice. The wound-healing effect of mesenchymal stem cells on cIRFB was also increased and associated with significant migration to the wound area. Conclusions: Wound healing is improved in a mouse model exposed to cFIRB. The ceramic blanket also promotes survival, proliferation, increased migration, and wound healing of MSCs without affecting their survival and proliferation. The utilization of cFIRB in cellular biology and medical applications may be promising in many situations currently explored in animal and human models. This technology needs no direct or battery power source and is entirely autonomous and noninvasive, making its application possible in any environment.
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spelling pubmed-84699262021-09-27 Accelerated Wound Healing Using a Novel Far-Infrared Ceramic Blanket Carrick, Frederick Robert Valerio, Luis Sebastian Alexis Gonzalez-Vega, Maxine N. Engel, David Sugaya, Kiminobu Life (Basel) Article Introduction: Wounds are associated with ranges of simple to complex disruption or damage to anatomical structure and function. They are also associated with enormous economic and social costs, increasing yearly, resulting in a severe impact on the wellbeing of individuals and society. Technology that might accelerate wound healing is associated with many benefits to injured people. Methods: BALBc mice underwent symmetrical excisional wounds through the panniculus carnosus. They were divided into a treatment group placed on an autonomous ceramic far-field infrared blanket (cIFRB) and a control group maintained under standard conditions. We also expanded and cultured adipose tissue-derived mesenchymal stem cells (MSCs) on cIFRB and compared them to standard conditions subjected to a scratch injury to compare survival, proliferation, and wound healing. Results: The wound healing of the cIRFB treatment group was significantly faster than the control group of mice. The wound-healing effect of mesenchymal stem cells on cIRFB was also increased and associated with significant migration to the wound area. Conclusions: Wound healing is improved in a mouse model exposed to cFIRB. The ceramic blanket also promotes survival, proliferation, increased migration, and wound healing of MSCs without affecting their survival and proliferation. The utilization of cFIRB in cellular biology and medical applications may be promising in many situations currently explored in animal and human models. This technology needs no direct or battery power source and is entirely autonomous and noninvasive, making its application possible in any environment. MDPI 2021-08-26 /pmc/articles/PMC8469926/ /pubmed/34575027 http://dx.doi.org/10.3390/life11090878 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Carrick, Frederick Robert
Valerio, Luis Sebastian Alexis
Gonzalez-Vega, Maxine N.
Engel, David
Sugaya, Kiminobu
Accelerated Wound Healing Using a Novel Far-Infrared Ceramic Blanket
title Accelerated Wound Healing Using a Novel Far-Infrared Ceramic Blanket
title_full Accelerated Wound Healing Using a Novel Far-Infrared Ceramic Blanket
title_fullStr Accelerated Wound Healing Using a Novel Far-Infrared Ceramic Blanket
title_full_unstemmed Accelerated Wound Healing Using a Novel Far-Infrared Ceramic Blanket
title_short Accelerated Wound Healing Using a Novel Far-Infrared Ceramic Blanket
title_sort accelerated wound healing using a novel far-infrared ceramic blanket
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469926/
https://www.ncbi.nlm.nih.gov/pubmed/34575027
http://dx.doi.org/10.3390/life11090878
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