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Deuterium Metabolic Imaging—Rediscovery of a Spectroscopic Tool

The growing demand for metabolism-specific imaging techniques has rekindled interest in Deuterium ((2)H) Metabolic Imaging (DMI), a robust method based on administration of a substrate (glucose, acetate, fumarate, etc.) labeled with the stable isotope of hydrogen and the observation of its metabolic...

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Detalles Bibliográficos
Autores principales: Polvoy, Ilona, Qin, Hecong, Flavell, Robert R., Gordon, Jeremy, Viswanath, Pavithra, Sriram, Renuka, Ohliger, Michael A., Wilson, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470013/
https://www.ncbi.nlm.nih.gov/pubmed/34564385
http://dx.doi.org/10.3390/metabo11090570
Descripción
Sumario:The growing demand for metabolism-specific imaging techniques has rekindled interest in Deuterium ((2)H) Metabolic Imaging (DMI), a robust method based on administration of a substrate (glucose, acetate, fumarate, etc.) labeled with the stable isotope of hydrogen and the observation of its metabolic fate in three-dimensions. This technique allows the investigation of multiple metabolic processes in both healthy and diseased states. Despite its low natural abundance, the short relaxation time of deuterium allows for rapid radiofrequency (RF) pulses without saturation and efficient image acquisition. In this review, we provide a comprehensive picture of the evolution of DMI over the course of recent decades, with a special focus on its potential clinical applications.