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Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model

Over the past years, promising results from studies have shown that herring milt hydrolysates (HMH) can counter immune-metabolic disorders associated with obesity. However, more studies must corroborate these results. Thus, three commercial hydrolysates (HMH1, HMH2, and HMH3) as well as the fraction...

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Autores principales: Benoit, Noémie, Dubois, Marie-Julie, Pilon, Geneviève, Varin, Thibault V., Marette, André, Bazinet, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470019/
https://www.ncbi.nlm.nih.gov/pubmed/34574156
http://dx.doi.org/10.3390/foods10092046
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author Benoit, Noémie
Dubois, Marie-Julie
Pilon, Geneviève
Varin, Thibault V.
Marette, André
Bazinet, Laurent
author_facet Benoit, Noémie
Dubois, Marie-Julie
Pilon, Geneviève
Varin, Thibault V.
Marette, André
Bazinet, Laurent
author_sort Benoit, Noémie
collection PubMed
description Over the past years, promising results from studies have shown that herring milt hydrolysates (HMH) can counter immune-metabolic disorders associated with obesity. However, more studies must corroborate these results. Thus, three commercial hydrolysates (HMH1, HMH2, and HMH3) as well as the fractions of two of them (HMH4 and HMH5) obtained by electrodialysis with ultrafiltration membranes (EDUF) were evaluated in vivo at higher doses compared to a previous study. To achieve this, seven groups of mice were fed for 8 weeks with either a control Chow diet or an obesogenic diet rich in fat and sucrose (HFHS) and supplemented by daily gavage with water or 312.5 mg/kg of one of the five HMH products. In summary, HMH supplements had no impact on weight gain. In the insulin tolerance test (ITT), HMH2 and its HMH5 fraction significantly reduced the blood sugar variation (p < 0.05). However, during the glucose tolerance (OGTT), HMH2 supplement increased the hyperinsulinemia variation (p < 0.05) induced by the HFHS diet. HMH1, HMH2, and HMH5 supplements generated potentially beneficial changes for health in the gut microbiota. These results reveal that HMH do not counteract obesity effects but may decrease certain physiological effects induced by obesity.
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spelling pubmed-84700192021-09-27 Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model Benoit, Noémie Dubois, Marie-Julie Pilon, Geneviève Varin, Thibault V. Marette, André Bazinet, Laurent Foods Article Over the past years, promising results from studies have shown that herring milt hydrolysates (HMH) can counter immune-metabolic disorders associated with obesity. However, more studies must corroborate these results. Thus, three commercial hydrolysates (HMH1, HMH2, and HMH3) as well as the fractions of two of them (HMH4 and HMH5) obtained by electrodialysis with ultrafiltration membranes (EDUF) were evaluated in vivo at higher doses compared to a previous study. To achieve this, seven groups of mice were fed for 8 weeks with either a control Chow diet or an obesogenic diet rich in fat and sucrose (HFHS) and supplemented by daily gavage with water or 312.5 mg/kg of one of the five HMH products. In summary, HMH supplements had no impact on weight gain. In the insulin tolerance test (ITT), HMH2 and its HMH5 fraction significantly reduced the blood sugar variation (p < 0.05). However, during the glucose tolerance (OGTT), HMH2 supplement increased the hyperinsulinemia variation (p < 0.05) induced by the HFHS diet. HMH1, HMH2, and HMH5 supplements generated potentially beneficial changes for health in the gut microbiota. These results reveal that HMH do not counteract obesity effects but may decrease certain physiological effects induced by obesity. MDPI 2021-08-31 /pmc/articles/PMC8470019/ /pubmed/34574156 http://dx.doi.org/10.3390/foods10092046 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Benoit, Noémie
Dubois, Marie-Julie
Pilon, Geneviève
Varin, Thibault V.
Marette, André
Bazinet, Laurent
Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model
title Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model
title_full Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model
title_fullStr Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model
title_full_unstemmed Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model
title_short Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model
title_sort effects of herring milt hydrolysates and fractions in a diet-induced obesity model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470019/
https://www.ncbi.nlm.nih.gov/pubmed/34574156
http://dx.doi.org/10.3390/foods10092046
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