Cargando…
The Transporter-Mediated Cellular Uptake and Efflux of Pharmaceutical Drugs and Biotechnology Products: How and Why Phospholipid Bilayer Transport Is Negligible in Real Biomembranes
Over the years, my colleagues and I have come to realise that the likelihood of pharmaceutical drugs being able to diffuse through whatever unhindered phospholipid bilayer may exist in intact biological membranes in vivo is vanishingly low. This is because (i) most real biomembranes are mostly prote...
Autor principal: | Kell, Douglas B. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470029/ https://www.ncbi.nlm.nih.gov/pubmed/34577099 http://dx.doi.org/10.3390/molecules26185629 |
Ejemplares similares
-
How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion
por: Kell, Douglas B., et al.
Publicado: (2014) -
Morphological and Physical Analysis of Natural Phospholipids-Based Biomembranes
por: Jacquot, Adrien, et al.
Publicado: (2014) -
Fitting Transporter Activities to Cellular Drug Concentrations and Fluxes: Why the Bumblebee Can Fly
por: Mendes, Pedro, et al.
Publicado: (2015) -
Enhanced biostability and cellular uptake of zinc oxide nanocrystals shielded with a phospholipid bilayer
por: Dumontel, B., et al.
Publicado: (2017) -
Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer (SALB) Method
por: Tabaei, Seyed R., et al.
Publicado: (2015)