Effect of Genetic Variation in CYP450 on Gonadal Impairment in a European Cohort of Female Childhood Cancer Survivors, Based on a Candidate Gene Approach: Results from the PanCareLIFE Study

SIMPLE SUMMARY: Childhood cancer patients receiving treatment containing alkylating agents are at risk of infertility, yet inter-individual variability in treatment-related ovarian damage is observed. Alkylating agents are metabolized by cytochrome P450 (CYP450) enzymes and polymorphisms in these CY...

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Autores principales: van der Perk, M. E. Madeleine, Broer, Linda, Yasui, Yutaka, Robison, Leslie L., Hudson, Melissa M., Laven, Joop S. E., van der Pal, Helena J., Tissing, Wim J. E., Versluys, Birgitta, Bresters, Dorine, Kaspers, Gertjan J. L., de Vries, Andrica C. H., Lambalk, Cornelis B., Overbeek, Annelies, Loonen, Jacqueline J., Beerendonk, Catharina C. M., Byrne, Julianne, Berger, Claire, Clemens, Eva, Dirksen, Uta, Falck Winther, Jeanette, Fosså, Sophie D., Grabow, Desiree, Muraca, Monica, Kaiser, Melanie, Kepák, Tomáš, Kruseova, Jarmila, Modan-Moses, Dalit, Spix, Claudia, Zolk, Oliver, Kaatsch, Peter, Krijthe, Jesse H., Kremer, Leontien C. M., Brooke, Russell J., Baedke, Jessica L., van Schaik, Ron H. N., van den Anker, John N., Uitterlinden, André G., Bos, Annelies M. E., van Leeuwen, Flora E., van Dulmen-den Broeder, Eline, van der Kooi, Anne-Lotte L. F., van den Heuvel-Eibrink, Marry M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470074/
https://www.ncbi.nlm.nih.gov/pubmed/34572825
http://dx.doi.org/10.3390/cancers13184598

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