A Mouse Model for Studying Post-Acute Arthritis of Chikungunya

Chikungunya virus (CHIKV) was introduced to the Americas in 2013, causing two million infections across over thirty countries. CHIKV causes a chronic debilitating arthritis in one fourth of infected individuals and currently evidence-based targeted therapies for the treatment of CHIKV arthritis are...

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Detalles Bibliográficos
Autores principales: Chang, Aileen Y., Tritsch, Sarah R., Porzucek, Abigail J., Schwartz, Arnold M., Seyler-Schmidt, Margaux, Glass, Arielle, Latham, Patricia S., Reid, St. Patrick, Simon, Gary L., Mores, Christopher N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470089/
https://www.ncbi.nlm.nih.gov/pubmed/34576893
http://dx.doi.org/10.3390/microorganisms9091998
Descripción
Sumario:Chikungunya virus (CHIKV) was introduced to the Americas in 2013, causing two million infections across over thirty countries. CHIKV causes a chronic debilitating arthritis in one fourth of infected individuals and currently evidence-based targeted therapies for the treatment of CHIKV arthritis are lacking. Multiple mouse models of chikungunya have been developed to study acute CHIKV infection. In humans, post-CHIKV arthritis may persist for months to years after viremia from a CHIKV infection has resolved. Therefore, the development of a mouse model of post-acute arthritis of chikungunya may facilitate the study of potential novel therapeutics for this arthritis. In this article we describe the development of a wild-type immunocompetent C57BL/6 mouse model for post-acute arthritis of chikungunya, including a histologic inflammation scoring system, as well as suggestions for how this mouse model may be used to examine the efficacy of novel therapies for CHIKV arthritis.

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