Cargando…

A Senescence Bystander Effect in Human Lung Fibroblasts

Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterised by a dense fibrosing of the lung parenchyma. An association between IPF and cellular senescence is well established and several studies now describe a higher abundance of senescent fibroblasts and epithelial cells in the lungs of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Waters, David W., Schuliga, Michael, Pathinayake, Prabuddha S., Wei, Lan, Tan, Hui-Ying, Blokland, Kaj E. C., Jaffar, Jade, Westall, Glen P., Burgess, Janette K., Prêle, Cecilia M., Mutsaers, Steven E., Grainge, Christopher L., Knight, Darryl A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470192/ https://www.ncbi.nlm.nih.gov/pubmed/34572347 http://dx.doi.org/10.3390/biomedicines9091162

Ejemplares similares

Senescence of IPF Lung Fibroblasts Disrupt Alveolar Epithelial Cell Proliferation and Promote Migration in Wound Healing
por: Blokland, Kaj E. C., et al.
Publicado: (2020)

Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts
por: Schuliga, Michael, et al.
Publicado: (2018)

Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases
por: Blokland, Kaj E.C., et al.
Publicado: (2020)

The fibrogenic actions of lung fibroblast-derived urokinase: a potential drug target in IPF
por: Schuliga, Michael, et al.
Publicado: (2017)

Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM
por: Blokland, Kaj E. C., et al.
Publicado: (2021)

Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts
por: Blokland, Kaj E. C., et al.
Publicado: (2022)

The contribution of animal models to understanding the role of the immune system in human idiopathic pulmonary fibrosis
por: Miles, Tylah, et al.
Publicado: (2020)

The Processes and Mechanisms of Cardiac and Pulmonary Fibrosis
por: Murtha, Lucy A., et al.
Publicado: (2017)

Reduced SOCS1 Expression in Lung Fibroblasts from Patients with IPF Is Not Mediated by Promoter Methylation or Mir155
por: Prêle, Cecilia M., et al.
Publicado: (2021)

A senescent cell bystander effect: senescence-induced senescence
por: Nelson, Glyn, et al.
Publicado: (2012)

Cytokines shape chemotherapy-induced and ‘bystander' senescence
por: Hodny, Zdenek, et al.
Publicado: (2010)

The Role of Pathological Aging in Cardiac and Pulmonary Fibrosis
por: Murtha, Lucy A., et al.
Publicado: (2019)

Type 2 Immunity and Its Impact on COVID-19 Infection in the Airways
por: Pathinayake, Prabuddha S., et al.
Publicado: (2023)

Cytokine-induced ‘bystander’ senescence in DDR and immuno-surveillance
por: Hodny, Zdenek, et al.
Publicado: (2013)

The bystander effect contributes to the accumulation of senescent cells in vivo
por: da Silva, Paulo F. L., et al.
Publicado: (2018)

Radiation-Induced Senescence Bystander Effect: The Role of Exosomes
por: Elbakrawy, Eman, et al.
Publicado: (2020)

Induction of T Cell Senescence by Cytokine Induced Bystander Activation
por: Abbas, Attiya A., et al.
Publicado: (2021)

Fibulin1C peptide induces cell attachment and extracellular matrix deposition in lung fibroblasts
por: Ge, Qi, et al.
Publicado: (2015)

Comparison of commercially available differentiation media on cell morphology, function, and anti-viral responses in conditionally reprogrammed human bronchial epithelial cells
por: Awatade, Nikhil T., et al.
Publicado: (2023)

Targeting microRNA to improve diagnostic and therapeutic approaches for malignant mesothelioma
por: Birnie, Kimberly A., et al.
Publicado: (2017)

Cancer-associated fibroblasts in radiotherapy: Bystanders or protagonists?
por: Martinez-Zubiaurre, Inigo, et al.
Publicado: (2023)

Plasma cell but not CD20-mediated B-cell depletion protects from bleomycin-induced lung fibrosis
por: Prêle, Cecilia M., et al.
Publicado: (2022)

Radiation induces senescence and a bystander effect through metabolic alterations
por: Liao, E-C, et al.
Publicado: (2014)

Innate Immunity and Immune Evasion by Enterovirus 71
por: Pathinayake, Prabuddha S., et al.
Publicado: (2015)

Mesothelial cells in tissue repair and fibrosis
por: Mutsaers, Steven E., et al.
Publicado: (2015)

Understanding the Unfolded Protein Response in the Pathogenesis of Asthma
por: Pathinayake, Prabuddha S., et al.
Publicado: (2018)

Casein Kinase 1δ/ε Inhibitor, PF670462 Attenuates the Fibrogenic Effects of Transforming Growth Factor-β in Pulmonary Fibrosis
por: Keenan, Christine R., et al.
Publicado: (2018)

Asthma, COPD and SARS-CoV-2 infection (COVID-19): potential mechanistic insights
por: Wark, Peter A.B., et al.
Publicado: (2021)

CXCR4(+) cells are increased in lung tissue of patients with idiopathic pulmonary fibrosis
por: Jaffar, Jade, et al.
Publicado: (2020)

Cancer-associated fibroblasts – Not-so-innocent bystanders in metastasis to bone?
por: Prajapati, Priyanka, et al.
Publicado: (2016)

Drug-induced senescence bystander proliferation in prostate cancer cells in vitro and in vivo
por: Ewald, J A, et al.
Publicado: (2008)

The senescent bystander effect is caused by ROS-activated NF-κB signalling
por: Nelson, Glyn, et al.
Publicado: (2018)

Selective Cardiomyocyte Oxidative Stress Leads to Bystander Senescence of Cardiac Stromal Cells
por: Martini, Hélène, et al.
Publicado: (2021)

Mutational Analysis of Hedgehog Signaling Pathway Genes in Human Malignant Mesothelioma
por: Lim, Chuan Bian, et al.
Publicado: (2013)

Distinct phenotypes and ‘bystander’ effects of senescent tumour cells induced by docetaxel or immunomodulatory cytokines
por: Sapega, Olena, et al.
Publicado: (2018)

Porphyromonas gingivalis Provokes Exosome Secretion and Paracrine Immune Senescence in Bystander Dendritic Cells
por: Elsayed, Ranya, et al.
Publicado: (2021)

Bystander
por: Gorky, Maksim, 1868-1936
Publicado: (1930)

Direct evidence for a bystander effect of ionizing radiation in primary human fibroblasts
por: Belyakov, O V, et al.
Publicado: (2001)

Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis
por: Lim, Chuan Bian, et al.
Publicado: (2015)

Bystander or No Bystander for Gene Directed Enzyme Prodrug Therapy
por: Dachs, Gabi U., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_i6ik2sdooudau18g7ur70e0u0b