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Intake of Koji Amazake Improves Defecation Frequency in Healthy Adults

Reportedly, the intake of koji amazake, a beverage made from steamed rice fermented by Aspergillus oryzae, improves defecation frequency. However, its functional ingredients and mechanism of action remain unclear. To compare the effects of koji amazake and a placebo beverage on defecation frequency...

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Autores principales: Kurahashi, Atsushi, Enomoto, Toshihiko, Oguro, Yoshifumi, Kojima-Nakamura, Ayana, Kodaira, Kazuya, Watanabe, Kenichi, Ozaki, Nobuhiro, Goto, Hiroshi, Hirayama, Masao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470246/
https://www.ncbi.nlm.nih.gov/pubmed/34575820
http://dx.doi.org/10.3390/jof7090782
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author Kurahashi, Atsushi
Enomoto, Toshihiko
Oguro, Yoshifumi
Kojima-Nakamura, Ayana
Kodaira, Kazuya
Watanabe, Kenichi
Ozaki, Nobuhiro
Goto, Hiroshi
Hirayama, Masao
author_facet Kurahashi, Atsushi
Enomoto, Toshihiko
Oguro, Yoshifumi
Kojima-Nakamura, Ayana
Kodaira, Kazuya
Watanabe, Kenichi
Ozaki, Nobuhiro
Goto, Hiroshi
Hirayama, Masao
author_sort Kurahashi, Atsushi
collection PubMed
description Reportedly, the intake of koji amazake, a beverage made from steamed rice fermented by Aspergillus oryzae, improves defecation frequency. However, its functional ingredients and mechanism of action remain unclear. To compare the effects of koji amazake and a placebo beverage on defecation frequency and to identify the functional ingredients and mechanism of action, a randomized, placebo-controlled, double-blind parallel-group comparative trial was performed on two groups. The koji amazake had 302 ± 15.5 mg/118 g of A. oryzae cells, which was not in the placebo. Compared with the placebo group, the koji amazake group showed a significant increase in weekly defecation frequency at 2 weeks (5.09 days vs. 4.14 days), 3 weeks (5.41 days vs. 4.18 days), and 4 weeks (5.09 days vs. 3.95 days), along with an increase in the weekly fecal weight at 4 weeks (724 g vs. 501 g). The intake of koji amazake did not induce significant intergroup differences in the fecal SCFA concentration, whereas it significantly decreased the relative abundance of Blautia and significantly increased that of Bacteroides at 3 weeks. Therefore, koji amazake intake improved defecation frequency, and A. oryzae cells played potentially important roles as functional ingredients.
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spelling pubmed-84702462021-09-27 Intake of Koji Amazake Improves Defecation Frequency in Healthy Adults Kurahashi, Atsushi Enomoto, Toshihiko Oguro, Yoshifumi Kojima-Nakamura, Ayana Kodaira, Kazuya Watanabe, Kenichi Ozaki, Nobuhiro Goto, Hiroshi Hirayama, Masao J Fungi (Basel) Article Reportedly, the intake of koji amazake, a beverage made from steamed rice fermented by Aspergillus oryzae, improves defecation frequency. However, its functional ingredients and mechanism of action remain unclear. To compare the effects of koji amazake and a placebo beverage on defecation frequency and to identify the functional ingredients and mechanism of action, a randomized, placebo-controlled, double-blind parallel-group comparative trial was performed on two groups. The koji amazake had 302 ± 15.5 mg/118 g of A. oryzae cells, which was not in the placebo. Compared with the placebo group, the koji amazake group showed a significant increase in weekly defecation frequency at 2 weeks (5.09 days vs. 4.14 days), 3 weeks (5.41 days vs. 4.18 days), and 4 weeks (5.09 days vs. 3.95 days), along with an increase in the weekly fecal weight at 4 weeks (724 g vs. 501 g). The intake of koji amazake did not induce significant intergroup differences in the fecal SCFA concentration, whereas it significantly decreased the relative abundance of Blautia and significantly increased that of Bacteroides at 3 weeks. Therefore, koji amazake intake improved defecation frequency, and A. oryzae cells played potentially important roles as functional ingredients. MDPI 2021-09-21 /pmc/articles/PMC8470246/ /pubmed/34575820 http://dx.doi.org/10.3390/jof7090782 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kurahashi, Atsushi
Enomoto, Toshihiko
Oguro, Yoshifumi
Kojima-Nakamura, Ayana
Kodaira, Kazuya
Watanabe, Kenichi
Ozaki, Nobuhiro
Goto, Hiroshi
Hirayama, Masao
Intake of Koji Amazake Improves Defecation Frequency in Healthy Adults
title Intake of Koji Amazake Improves Defecation Frequency in Healthy Adults
title_full Intake of Koji Amazake Improves Defecation Frequency in Healthy Adults
title_fullStr Intake of Koji Amazake Improves Defecation Frequency in Healthy Adults
title_full_unstemmed Intake of Koji Amazake Improves Defecation Frequency in Healthy Adults
title_short Intake of Koji Amazake Improves Defecation Frequency in Healthy Adults
title_sort intake of koji amazake improves defecation frequency in healthy adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470246/
https://www.ncbi.nlm.nih.gov/pubmed/34575820
http://dx.doi.org/10.3390/jof7090782
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