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Intake of Koji Amazake Improves Defecation Frequency in Healthy Adults
Reportedly, the intake of koji amazake, a beverage made from steamed rice fermented by Aspergillus oryzae, improves defecation frequency. However, its functional ingredients and mechanism of action remain unclear. To compare the effects of koji amazake and a placebo beverage on defecation frequency...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470246/ https://www.ncbi.nlm.nih.gov/pubmed/34575820 http://dx.doi.org/10.3390/jof7090782 |
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author | Kurahashi, Atsushi Enomoto, Toshihiko Oguro, Yoshifumi Kojima-Nakamura, Ayana Kodaira, Kazuya Watanabe, Kenichi Ozaki, Nobuhiro Goto, Hiroshi Hirayama, Masao |
author_facet | Kurahashi, Atsushi Enomoto, Toshihiko Oguro, Yoshifumi Kojima-Nakamura, Ayana Kodaira, Kazuya Watanabe, Kenichi Ozaki, Nobuhiro Goto, Hiroshi Hirayama, Masao |
author_sort | Kurahashi, Atsushi |
collection | PubMed |
description | Reportedly, the intake of koji amazake, a beverage made from steamed rice fermented by Aspergillus oryzae, improves defecation frequency. However, its functional ingredients and mechanism of action remain unclear. To compare the effects of koji amazake and a placebo beverage on defecation frequency and to identify the functional ingredients and mechanism of action, a randomized, placebo-controlled, double-blind parallel-group comparative trial was performed on two groups. The koji amazake had 302 ± 15.5 mg/118 g of A. oryzae cells, which was not in the placebo. Compared with the placebo group, the koji amazake group showed a significant increase in weekly defecation frequency at 2 weeks (5.09 days vs. 4.14 days), 3 weeks (5.41 days vs. 4.18 days), and 4 weeks (5.09 days vs. 3.95 days), along with an increase in the weekly fecal weight at 4 weeks (724 g vs. 501 g). The intake of koji amazake did not induce significant intergroup differences in the fecal SCFA concentration, whereas it significantly decreased the relative abundance of Blautia and significantly increased that of Bacteroides at 3 weeks. Therefore, koji amazake intake improved defecation frequency, and A. oryzae cells played potentially important roles as functional ingredients. |
format | Online Article Text |
id | pubmed-8470246 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84702462021-09-27 Intake of Koji Amazake Improves Defecation Frequency in Healthy Adults Kurahashi, Atsushi Enomoto, Toshihiko Oguro, Yoshifumi Kojima-Nakamura, Ayana Kodaira, Kazuya Watanabe, Kenichi Ozaki, Nobuhiro Goto, Hiroshi Hirayama, Masao J Fungi (Basel) Article Reportedly, the intake of koji amazake, a beverage made from steamed rice fermented by Aspergillus oryzae, improves defecation frequency. However, its functional ingredients and mechanism of action remain unclear. To compare the effects of koji amazake and a placebo beverage on defecation frequency and to identify the functional ingredients and mechanism of action, a randomized, placebo-controlled, double-blind parallel-group comparative trial was performed on two groups. The koji amazake had 302 ± 15.5 mg/118 g of A. oryzae cells, which was not in the placebo. Compared with the placebo group, the koji amazake group showed a significant increase in weekly defecation frequency at 2 weeks (5.09 days vs. 4.14 days), 3 weeks (5.41 days vs. 4.18 days), and 4 weeks (5.09 days vs. 3.95 days), along with an increase in the weekly fecal weight at 4 weeks (724 g vs. 501 g). The intake of koji amazake did not induce significant intergroup differences in the fecal SCFA concentration, whereas it significantly decreased the relative abundance of Blautia and significantly increased that of Bacteroides at 3 weeks. Therefore, koji amazake intake improved defecation frequency, and A. oryzae cells played potentially important roles as functional ingredients. MDPI 2021-09-21 /pmc/articles/PMC8470246/ /pubmed/34575820 http://dx.doi.org/10.3390/jof7090782 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kurahashi, Atsushi Enomoto, Toshihiko Oguro, Yoshifumi Kojima-Nakamura, Ayana Kodaira, Kazuya Watanabe, Kenichi Ozaki, Nobuhiro Goto, Hiroshi Hirayama, Masao Intake of Koji Amazake Improves Defecation Frequency in Healthy Adults |
title | Intake of Koji Amazake Improves Defecation Frequency in Healthy Adults |
title_full | Intake of Koji Amazake Improves Defecation Frequency in Healthy Adults |
title_fullStr | Intake of Koji Amazake Improves Defecation Frequency in Healthy Adults |
title_full_unstemmed | Intake of Koji Amazake Improves Defecation Frequency in Healthy Adults |
title_short | Intake of Koji Amazake Improves Defecation Frequency in Healthy Adults |
title_sort | intake of koji amazake improves defecation frequency in healthy adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470246/ https://www.ncbi.nlm.nih.gov/pubmed/34575820 http://dx.doi.org/10.3390/jof7090782 |
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