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Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients

Background: Derangement of liver blood tests (LBT) is frequent in patients with Coronavirus disease 2019 (COVID-19). We aimed to evaluate (a) the prevalence of deranged LBT as well as their association with (b) clinical severity at admission and (c) 30-day outcomes among the hospitalized patients wi...

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Autores principales: Paštrovic, Frane, Lucijanic, Marko, Atic, Armin, Stojic, Josip, Barisic Jaman, Mislav, Tjesic Drinkovic, Ida, Zelenika, Marko, Milosevic, Marko, Medic, Barbara, Loncar, Jelena, Mijic, Maja, Filipec Kanizaj, Tajana, Kralj, Dominik, Lerotic, Ivan, Virovic Jukic, Lucija, Ljubicic, Neven, Luetic, Kresimir, Grgic, Dora, Majerovic, Matea, Ostojic, Rajko, Krznaric, Zeljko, Luksic, Ivica, Piskac Zivkovic, Nevenka, Keres, Tatjana, Grabovac, Vlatko, Persec, Jasminka, Barsic, Bruno, Grgurevic, Ivica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470265/
https://www.ncbi.nlm.nih.gov/pubmed/34575333
http://dx.doi.org/10.3390/jcm10184222
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author Paštrovic, Frane
Lucijanic, Marko
Atic, Armin
Stojic, Josip
Barisic Jaman, Mislav
Tjesic Drinkovic, Ida
Zelenika, Marko
Milosevic, Marko
Medic, Barbara
Loncar, Jelena
Mijic, Maja
Filipec Kanizaj, Tajana
Kralj, Dominik
Lerotic, Ivan
Virovic Jukic, Lucija
Ljubicic, Neven
Luetic, Kresimir
Grgic, Dora
Majerovic, Matea
Ostojic, Rajko
Krznaric, Zeljko
Luksic, Ivica
Piskac Zivkovic, Nevenka
Keres, Tatjana
Grabovac, Vlatko
Persec, Jasminka
Barsic, Bruno
Grgurevic, Ivica
author_facet Paštrovic, Frane
Lucijanic, Marko
Atic, Armin
Stojic, Josip
Barisic Jaman, Mislav
Tjesic Drinkovic, Ida
Zelenika, Marko
Milosevic, Marko
Medic, Barbara
Loncar, Jelena
Mijic, Maja
Filipec Kanizaj, Tajana
Kralj, Dominik
Lerotic, Ivan
Virovic Jukic, Lucija
Ljubicic, Neven
Luetic, Kresimir
Grgic, Dora
Majerovic, Matea
Ostojic, Rajko
Krznaric, Zeljko
Luksic, Ivica
Piskac Zivkovic, Nevenka
Keres, Tatjana
Grabovac, Vlatko
Persec, Jasminka
Barsic, Bruno
Grgurevic, Ivica
author_sort Paštrovic, Frane
collection PubMed
description Background: Derangement of liver blood tests (LBT) is frequent in patients with Coronavirus disease 2019 (COVID-19). We aimed to evaluate (a) the prevalence of deranged LBT as well as their association with (b) clinical severity at admission and (c) 30-day outcomes among the hospitalized patients with COVID-19. Methods: Consecutive patients with COVID-19 hospitalized in the regional referral center over the 12-month period were included. Clinical severity of COVID-19 at hospital admission and 30-day outcomes (need for intensive care, mechanical ventilation, or death) were analyzed. Results: Derangement of LBT occurred in 2854/3812 (74.9%) of patients, most frequently due to elevation of AST (61.6%), GGT (46.1%) and ALT (33.4%). Elevated AST, ALT, GGT and low albumin were associated with more severe disease at admission. However, in multivariate Cox regression analysis, when adjusted for age, sex, obesity and presence of chronic liver disease, only AST remained associated with the risk of dying (HR 1.5081 and 2.1315, for elevations 1–3 × ULN and >3 × ULN, respectively) independently of comorbidity burden and COVID-19 severity at admission. Patients with more severe liver injury more frequently experienced defined adverse outcomes. Conclusions: Deranged LBTs are common among patients hospitalized with COVID-19 and might be used as predictors of adverse clinical outcomes.
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spelling pubmed-84702652021-09-27 Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients Paštrovic, Frane Lucijanic, Marko Atic, Armin Stojic, Josip Barisic Jaman, Mislav Tjesic Drinkovic, Ida Zelenika, Marko Milosevic, Marko Medic, Barbara Loncar, Jelena Mijic, Maja Filipec Kanizaj, Tajana Kralj, Dominik Lerotic, Ivan Virovic Jukic, Lucija Ljubicic, Neven Luetic, Kresimir Grgic, Dora Majerovic, Matea Ostojic, Rajko Krznaric, Zeljko Luksic, Ivica Piskac Zivkovic, Nevenka Keres, Tatjana Grabovac, Vlatko Persec, Jasminka Barsic, Bruno Grgurevic, Ivica J Clin Med Article Background: Derangement of liver blood tests (LBT) is frequent in patients with Coronavirus disease 2019 (COVID-19). We aimed to evaluate (a) the prevalence of deranged LBT as well as their association with (b) clinical severity at admission and (c) 30-day outcomes among the hospitalized patients with COVID-19. Methods: Consecutive patients with COVID-19 hospitalized in the regional referral center over the 12-month period were included. Clinical severity of COVID-19 at hospital admission and 30-day outcomes (need for intensive care, mechanical ventilation, or death) were analyzed. Results: Derangement of LBT occurred in 2854/3812 (74.9%) of patients, most frequently due to elevation of AST (61.6%), GGT (46.1%) and ALT (33.4%). Elevated AST, ALT, GGT and low albumin were associated with more severe disease at admission. However, in multivariate Cox regression analysis, when adjusted for age, sex, obesity and presence of chronic liver disease, only AST remained associated with the risk of dying (HR 1.5081 and 2.1315, for elevations 1–3 × ULN and >3 × ULN, respectively) independently of comorbidity burden and COVID-19 severity at admission. Patients with more severe liver injury more frequently experienced defined adverse outcomes. Conclusions: Deranged LBTs are common among patients hospitalized with COVID-19 and might be used as predictors of adverse clinical outcomes. MDPI 2021-09-17 /pmc/articles/PMC8470265/ /pubmed/34575333 http://dx.doi.org/10.3390/jcm10184222 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Paštrovic, Frane
Lucijanic, Marko
Atic, Armin
Stojic, Josip
Barisic Jaman, Mislav
Tjesic Drinkovic, Ida
Zelenika, Marko
Milosevic, Marko
Medic, Barbara
Loncar, Jelena
Mijic, Maja
Filipec Kanizaj, Tajana
Kralj, Dominik
Lerotic, Ivan
Virovic Jukic, Lucija
Ljubicic, Neven
Luetic, Kresimir
Grgic, Dora
Majerovic, Matea
Ostojic, Rajko
Krznaric, Zeljko
Luksic, Ivica
Piskac Zivkovic, Nevenka
Keres, Tatjana
Grabovac, Vlatko
Persec, Jasminka
Barsic, Bruno
Grgurevic, Ivica
Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients
title Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients
title_full Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients
title_fullStr Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients
title_full_unstemmed Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients
title_short Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients
title_sort prevalence and prognostic impact of deranged liver blood tests in covid-19: experience from the regional covid-19 center over the cohort of 3812 hospitalized patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470265/
https://www.ncbi.nlm.nih.gov/pubmed/34575333
http://dx.doi.org/10.3390/jcm10184222
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