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Stress-Induced Epstein-Barr Virus Reactivation

Epstein-Barr virus (EBV) is typically found in a latent, asymptomatic state in immunocompetent individuals. Perturbations of the host immune system can stimulate viral reactivation. Furthermore, there are a myriad of EBV-associated illnesses including various cancers, post-transplant lymphoprolifera...

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Autores principales: Sausen, Daniel G., Bhutta, Maimoona S., Gallo, Elisa S., Dahari, Harel, Borenstein, Ronen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470332/
https://www.ncbi.nlm.nih.gov/pubmed/34572593
http://dx.doi.org/10.3390/biom11091380
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author Sausen, Daniel G.
Bhutta, Maimoona S.
Gallo, Elisa S.
Dahari, Harel
Borenstein, Ronen
author_facet Sausen, Daniel G.
Bhutta, Maimoona S.
Gallo, Elisa S.
Dahari, Harel
Borenstein, Ronen
author_sort Sausen, Daniel G.
collection PubMed
description Epstein-Barr virus (EBV) is typically found in a latent, asymptomatic state in immunocompetent individuals. Perturbations of the host immune system can stimulate viral reactivation. Furthermore, there are a myriad of EBV-associated illnesses including various cancers, post-transplant lymphoproliferative disease, and autoimmune conditions. A thorough understanding of this virus, and the interplay between stress and the immune system, is essential to establish effective treatment. This review will provide a summary of the interaction between both psychological and cellular stressors resulting in EBV reactivation. It will examine mechanisms by which EBV establishes and maintains latency and will conclude with a brief overview of treatments targeting EBV.
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spelling pubmed-84703322021-09-27 Stress-Induced Epstein-Barr Virus Reactivation Sausen, Daniel G. Bhutta, Maimoona S. Gallo, Elisa S. Dahari, Harel Borenstein, Ronen Biomolecules Review Epstein-Barr virus (EBV) is typically found in a latent, asymptomatic state in immunocompetent individuals. Perturbations of the host immune system can stimulate viral reactivation. Furthermore, there are a myriad of EBV-associated illnesses including various cancers, post-transplant lymphoproliferative disease, and autoimmune conditions. A thorough understanding of this virus, and the interplay between stress and the immune system, is essential to establish effective treatment. This review will provide a summary of the interaction between both psychological and cellular stressors resulting in EBV reactivation. It will examine mechanisms by which EBV establishes and maintains latency and will conclude with a brief overview of treatments targeting EBV. MDPI 2021-09-18 /pmc/articles/PMC8470332/ /pubmed/34572593 http://dx.doi.org/10.3390/biom11091380 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sausen, Daniel G.
Bhutta, Maimoona S.
Gallo, Elisa S.
Dahari, Harel
Borenstein, Ronen
Stress-Induced Epstein-Barr Virus Reactivation
title Stress-Induced Epstein-Barr Virus Reactivation
title_full Stress-Induced Epstein-Barr Virus Reactivation
title_fullStr Stress-Induced Epstein-Barr Virus Reactivation
title_full_unstemmed Stress-Induced Epstein-Barr Virus Reactivation
title_short Stress-Induced Epstein-Barr Virus Reactivation
title_sort stress-induced epstein-barr virus reactivation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470332/
https://www.ncbi.nlm.nih.gov/pubmed/34572593
http://dx.doi.org/10.3390/biom11091380
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