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Polylactide Nanocapsules Attenuate Adverse Cardiac Cellular Effects of Lyso-7, a Pan-PPAR Agonist/Anti-Inflammatory New Thiazolidinedione

Lyso-7 is a novel synthetic thiazolidinedione, which is a receptor (pan) agonist of PPAR α,β/δ,γ with anti-inflammatory activity. We investigated the cardiotoxicity of free Lyso-7 in vitro (4.5–450 nM), and Lyso-7 loaded in polylactic acid nanocapsules (NC) in vivo (Lyso-7-NC, 1.6 mg/kg). In previou...

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Detalles Bibliográficos
Autores principales:	Garcia, Giani M., Roy, Jérôme, Pitta, Ivan R., Abdalla, Dulcinéia S. P., Grabe-Guimarães, Andrea, Mosqueira, Vanessa C. F., Richard, Sylvain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470374/ https://www.ncbi.nlm.nih.gov/pubmed/34575597 http://dx.doi.org/10.3390/pharmaceutics13091521

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