Cargando…

Metabolic Profile and Bone Status in Post-Menopausal Women with Rheumatoid Arthritis: A Monocentric Retrospective Survey

Background: Rheumatoid arthritis (RA) and metabolic syndrome (MetS) are chronic conditions that share common inflammatory mechanisms. Both diseases can lead to an impairment of the bone microarchitecture. The aims of our study were to evaluate clinical, metabolic, and bone parameters in RA patients...

Descripción completa

Detalles Bibliográficos
Autores principales: Paolino, Sabrina, Hysa, Elvis, Stoian, Sabrina Atena, Gotelli, Emanuele, Casabella, Andrea, Clini, Paolo Vittoriano, Pacini, Greta, Pizzorni, Carmen, Sulli, Alberto, Nikiphorou, Elena, Smith, Vanessa, Cutolo, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470504/
https://www.ncbi.nlm.nih.gov/pubmed/34579044
http://dx.doi.org/10.3390/nu13093168
_version_ 1784574216420458496
author Paolino, Sabrina
Hysa, Elvis
Stoian, Sabrina Atena
Gotelli, Emanuele
Casabella, Andrea
Clini, Paolo Vittoriano
Pacini, Greta
Pizzorni, Carmen
Sulli, Alberto
Nikiphorou, Elena
Smith, Vanessa
Cutolo, Maurizio
author_facet Paolino, Sabrina
Hysa, Elvis
Stoian, Sabrina Atena
Gotelli, Emanuele
Casabella, Andrea
Clini, Paolo Vittoriano
Pacini, Greta
Pizzorni, Carmen
Sulli, Alberto
Nikiphorou, Elena
Smith, Vanessa
Cutolo, Maurizio
author_sort Paolino, Sabrina
collection PubMed
description Background: Rheumatoid arthritis (RA) and metabolic syndrome (MetS) are chronic conditions that share common inflammatory mechanisms. Both diseases can lead to an impairment of the bone microarchitecture. The aims of our study were to evaluate clinical, metabolic, and bone parameters in RA patients with or without MetS (MetS+, MetS−) and potential correlations between the glico-lipidic profile, RA disease activity, and bone status. Methods: A total of thirty-nine RA female post-menopausal patients were recruited (median age 66.6 ± 10.4, disease duration 3 ± 2.7). Anthropometric data, medical history, and current treatment were recorded along with basal blood tests, bone, and lipid metabolism biomarkers. RA disease activity and insulin resistance were evaluated through standard scores. Quantitative assessment of the bone (bone mineral density—BMD) was performed by dual-energy-X ray absorption (DXA), whereas bone quality was quantified with the trabecular bone score (TBS). Results: No statistically significant differences concerning both BMD and TBS were detected between the MetS+ and MetS− RA patients. However, the MetS+ RA patients exhibited significantly higher disease activity and lower serum 25-hydroxyvitamin D [25(OH)D] concentrations (respectively, p = 0.04 and p = 0.01). In all RA patients, a significant negative correlation emerged between the BMD of the femoral trochanter with plasmatic triglycerides (TG) concentrations (r = −0.38, p = 0.01), whereas the lumbar BMD was positively correlated with the abdominal waist (AW) and fasting glucose (FG) concentrations. On the other hand, the TBS was negatively correlated with insulin concentrations, FG, and RA disease activity (respectively, r = −0.45, p = 0.01, r = −0.40, p = 0.03, r = −0.37, p = 0.04), the last one was further negatively correlated with 25-OHD serum concentrations (r = −0.6, p = 0.0006) and insulin-resistance (r = 0.3, p = 0.04). Conclusions: Bone quantity (BMD) and quality (TBS) do not seem significantly changed among MetS+ and MetS− RA patients; however, among MetS+ patients, both significantly higher disease activity and lower vitamin D serum concentrations were observed. In addition, the significant negative correlations between the alterations of metabolic parameters limited to the TBS in all RA patients might suggest that qualitative bone microarchitecture impairments (TBS) might manifest despite unchanged BMD values.
format Online
Article
Text
id pubmed-8470504
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84705042021-09-27 Metabolic Profile and Bone Status in Post-Menopausal Women with Rheumatoid Arthritis: A Monocentric Retrospective Survey Paolino, Sabrina Hysa, Elvis Stoian, Sabrina Atena Gotelli, Emanuele Casabella, Andrea Clini, Paolo Vittoriano Pacini, Greta Pizzorni, Carmen Sulli, Alberto Nikiphorou, Elena Smith, Vanessa Cutolo, Maurizio Nutrients Article Background: Rheumatoid arthritis (RA) and metabolic syndrome (MetS) are chronic conditions that share common inflammatory mechanisms. Both diseases can lead to an impairment of the bone microarchitecture. The aims of our study were to evaluate clinical, metabolic, and bone parameters in RA patients with or without MetS (MetS+, MetS−) and potential correlations between the glico-lipidic profile, RA disease activity, and bone status. Methods: A total of thirty-nine RA female post-menopausal patients were recruited (median age 66.6 ± 10.4, disease duration 3 ± 2.7). Anthropometric data, medical history, and current treatment were recorded along with basal blood tests, bone, and lipid metabolism biomarkers. RA disease activity and insulin resistance were evaluated through standard scores. Quantitative assessment of the bone (bone mineral density—BMD) was performed by dual-energy-X ray absorption (DXA), whereas bone quality was quantified with the trabecular bone score (TBS). Results: No statistically significant differences concerning both BMD and TBS were detected between the MetS+ and MetS− RA patients. However, the MetS+ RA patients exhibited significantly higher disease activity and lower serum 25-hydroxyvitamin D [25(OH)D] concentrations (respectively, p = 0.04 and p = 0.01). In all RA patients, a significant negative correlation emerged between the BMD of the femoral trochanter with plasmatic triglycerides (TG) concentrations (r = −0.38, p = 0.01), whereas the lumbar BMD was positively correlated with the abdominal waist (AW) and fasting glucose (FG) concentrations. On the other hand, the TBS was negatively correlated with insulin concentrations, FG, and RA disease activity (respectively, r = −0.45, p = 0.01, r = −0.40, p = 0.03, r = −0.37, p = 0.04), the last one was further negatively correlated with 25-OHD serum concentrations (r = −0.6, p = 0.0006) and insulin-resistance (r = 0.3, p = 0.04). Conclusions: Bone quantity (BMD) and quality (TBS) do not seem significantly changed among MetS+ and MetS− RA patients; however, among MetS+ patients, both significantly higher disease activity and lower vitamin D serum concentrations were observed. In addition, the significant negative correlations between the alterations of metabolic parameters limited to the TBS in all RA patients might suggest that qualitative bone microarchitecture impairments (TBS) might manifest despite unchanged BMD values. MDPI 2021-09-11 /pmc/articles/PMC8470504/ /pubmed/34579044 http://dx.doi.org/10.3390/nu13093168 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Paolino, Sabrina
Hysa, Elvis
Stoian, Sabrina Atena
Gotelli, Emanuele
Casabella, Andrea
Clini, Paolo Vittoriano
Pacini, Greta
Pizzorni, Carmen
Sulli, Alberto
Nikiphorou, Elena
Smith, Vanessa
Cutolo, Maurizio
Metabolic Profile and Bone Status in Post-Menopausal Women with Rheumatoid Arthritis: A Monocentric Retrospective Survey
title Metabolic Profile and Bone Status in Post-Menopausal Women with Rheumatoid Arthritis: A Monocentric Retrospective Survey
title_full Metabolic Profile and Bone Status in Post-Menopausal Women with Rheumatoid Arthritis: A Monocentric Retrospective Survey
title_fullStr Metabolic Profile and Bone Status in Post-Menopausal Women with Rheumatoid Arthritis: A Monocentric Retrospective Survey
title_full_unstemmed Metabolic Profile and Bone Status in Post-Menopausal Women with Rheumatoid Arthritis: A Monocentric Retrospective Survey
title_short Metabolic Profile and Bone Status in Post-Menopausal Women with Rheumatoid Arthritis: A Monocentric Retrospective Survey
title_sort metabolic profile and bone status in post-menopausal women with rheumatoid arthritis: a monocentric retrospective survey
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470504/
https://www.ncbi.nlm.nih.gov/pubmed/34579044
http://dx.doi.org/10.3390/nu13093168
work_keys_str_mv AT paolinosabrina metabolicprofileandbonestatusinpostmenopausalwomenwithrheumatoidarthritisamonocentricretrospectivesurvey
AT hysaelvis metabolicprofileandbonestatusinpostmenopausalwomenwithrheumatoidarthritisamonocentricretrospectivesurvey
AT stoiansabrinaatena metabolicprofileandbonestatusinpostmenopausalwomenwithrheumatoidarthritisamonocentricretrospectivesurvey
AT gotelliemanuele metabolicprofileandbonestatusinpostmenopausalwomenwithrheumatoidarthritisamonocentricretrospectivesurvey
AT casabellaandrea metabolicprofileandbonestatusinpostmenopausalwomenwithrheumatoidarthritisamonocentricretrospectivesurvey
AT clinipaolovittoriano metabolicprofileandbonestatusinpostmenopausalwomenwithrheumatoidarthritisamonocentricretrospectivesurvey
AT pacinigreta metabolicprofileandbonestatusinpostmenopausalwomenwithrheumatoidarthritisamonocentricretrospectivesurvey
AT pizzornicarmen metabolicprofileandbonestatusinpostmenopausalwomenwithrheumatoidarthritisamonocentricretrospectivesurvey
AT sullialberto metabolicprofileandbonestatusinpostmenopausalwomenwithrheumatoidarthritisamonocentricretrospectivesurvey
AT nikiphorouelena metabolicprofileandbonestatusinpostmenopausalwomenwithrheumatoidarthritisamonocentricretrospectivesurvey
AT smithvanessa metabolicprofileandbonestatusinpostmenopausalwomenwithrheumatoidarthritisamonocentricretrospectivesurvey
AT cutolomaurizio metabolicprofileandbonestatusinpostmenopausalwomenwithrheumatoidarthritisamonocentricretrospectivesurvey