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The Value of Residual Volume/Total Lung Capacity as an Indicator for Predicting Postoperative Lung Function in Non-Small Lung Cancer
Chronic obstructive pulmonary disease (COPD) is one of the most frequently occurring concomitant diseases in patients with non-small cell lung cancer (NSCLC). It is characterized by small airways and the hyperinflation of the lung. Patients with hyperinflated lung tend to have more reserved lung fun...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470520/ https://www.ncbi.nlm.nih.gov/pubmed/34575273 http://dx.doi.org/10.3390/jcm10184159 |
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author | Kwon, Oh-Beom Yeo, Chang-Dong Lee, Hwa-Young Kang, Hye-Seon Kim, Sung-Kyoung Kim, Ju-Sang Park, Chan-Kwon Lee, Sang-Haak Kim, Seung-Joon Kim, Jin-Woo |
author_facet | Kwon, Oh-Beom Yeo, Chang-Dong Lee, Hwa-Young Kang, Hye-Seon Kim, Sung-Kyoung Kim, Ju-Sang Park, Chan-Kwon Lee, Sang-Haak Kim, Seung-Joon Kim, Jin-Woo |
author_sort | Kwon, Oh-Beom |
collection | PubMed |
description | Chronic obstructive pulmonary disease (COPD) is one of the most frequently occurring concomitant diseases in patients with non-small cell lung cancer (NSCLC). It is characterized by small airways and the hyperinflation of the lung. Patients with hyperinflated lung tend to have more reserved lung function than conventionally predicted after lung cancer surgery. The aim of this study was to identify other indicators in predicting postoperative lung function after lung resection for lung cancer. Patients with NSCLC who underwent curative lobectomy with mediastinal lymph node dissection from 2017 to 2019 were included. Predicted postoperative FEV(1) (ppoFEV(1)) was calculated using the formula: preoperative FEV(1) × (19 segments-the number of segments to be removed) ÷ 19. The difference between the measured postoperative FEV(1) and ppoFEV(1) was defined as an outcome. Patients were categorized into two groups: preserved FEV(1) if the difference was positive and non-preserved FEV(1), if otherwise. In total, 238 patients were included: 74 (31.1%) in the FEV(1) non-preserved group and 164 (68.9%) in the FEV(1) preserved group. The proportion of preoperative residual volume (RV)/total lung capacity (TLC) ≥ 40% in the FEV(1) non-preserved group (21.4%) was lower than in the preserved group (36.1%) (p = 0.03). In logistic regression analysis, preoperative RV/TLC ≥ 40% was related to postoperative FEV1 preservation. (adjusted OR, 2.02, p = 0.041). Linear regression analysis suggested that preoperative RV/TLC was positively correlated with a significant difference. (p = 0.004) Preoperative RV/TLC ≥ 40% was an independent predictor of preserved lung function in patients undergoing curative lobectomy with mediastinal lymph node dissection. Preoperative RV/TLC is positively correlated with postoperative lung function. |
format | Online Article Text |
id | pubmed-8470520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84705202021-09-27 The Value of Residual Volume/Total Lung Capacity as an Indicator for Predicting Postoperative Lung Function in Non-Small Lung Cancer Kwon, Oh-Beom Yeo, Chang-Dong Lee, Hwa-Young Kang, Hye-Seon Kim, Sung-Kyoung Kim, Ju-Sang Park, Chan-Kwon Lee, Sang-Haak Kim, Seung-Joon Kim, Jin-Woo J Clin Med Article Chronic obstructive pulmonary disease (COPD) is one of the most frequently occurring concomitant diseases in patients with non-small cell lung cancer (NSCLC). It is characterized by small airways and the hyperinflation of the lung. Patients with hyperinflated lung tend to have more reserved lung function than conventionally predicted after lung cancer surgery. The aim of this study was to identify other indicators in predicting postoperative lung function after lung resection for lung cancer. Patients with NSCLC who underwent curative lobectomy with mediastinal lymph node dissection from 2017 to 2019 were included. Predicted postoperative FEV(1) (ppoFEV(1)) was calculated using the formula: preoperative FEV(1) × (19 segments-the number of segments to be removed) ÷ 19. The difference between the measured postoperative FEV(1) and ppoFEV(1) was defined as an outcome. Patients were categorized into two groups: preserved FEV(1) if the difference was positive and non-preserved FEV(1), if otherwise. In total, 238 patients were included: 74 (31.1%) in the FEV(1) non-preserved group and 164 (68.9%) in the FEV(1) preserved group. The proportion of preoperative residual volume (RV)/total lung capacity (TLC) ≥ 40% in the FEV(1) non-preserved group (21.4%) was lower than in the preserved group (36.1%) (p = 0.03). In logistic regression analysis, preoperative RV/TLC ≥ 40% was related to postoperative FEV1 preservation. (adjusted OR, 2.02, p = 0.041). Linear regression analysis suggested that preoperative RV/TLC was positively correlated with a significant difference. (p = 0.004) Preoperative RV/TLC ≥ 40% was an independent predictor of preserved lung function in patients undergoing curative lobectomy with mediastinal lymph node dissection. Preoperative RV/TLC is positively correlated with postoperative lung function. MDPI 2021-09-15 /pmc/articles/PMC8470520/ /pubmed/34575273 http://dx.doi.org/10.3390/jcm10184159 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kwon, Oh-Beom Yeo, Chang-Dong Lee, Hwa-Young Kang, Hye-Seon Kim, Sung-Kyoung Kim, Ju-Sang Park, Chan-Kwon Lee, Sang-Haak Kim, Seung-Joon Kim, Jin-Woo The Value of Residual Volume/Total Lung Capacity as an Indicator for Predicting Postoperative Lung Function in Non-Small Lung Cancer |
title | The Value of Residual Volume/Total Lung Capacity as an Indicator for Predicting Postoperative Lung Function in Non-Small Lung Cancer |
title_full | The Value of Residual Volume/Total Lung Capacity as an Indicator for Predicting Postoperative Lung Function in Non-Small Lung Cancer |
title_fullStr | The Value of Residual Volume/Total Lung Capacity as an Indicator for Predicting Postoperative Lung Function in Non-Small Lung Cancer |
title_full_unstemmed | The Value of Residual Volume/Total Lung Capacity as an Indicator for Predicting Postoperative Lung Function in Non-Small Lung Cancer |
title_short | The Value of Residual Volume/Total Lung Capacity as an Indicator for Predicting Postoperative Lung Function in Non-Small Lung Cancer |
title_sort | value of residual volume/total lung capacity as an indicator for predicting postoperative lung function in non-small lung cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470520/ https://www.ncbi.nlm.nih.gov/pubmed/34575273 http://dx.doi.org/10.3390/jcm10184159 |
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