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The Value of Residual Volume/Total Lung Capacity as an Indicator for Predicting Postoperative Lung Function in Non-Small Lung Cancer

Chronic obstructive pulmonary disease (COPD) is one of the most frequently occurring concomitant diseases in patients with non-small cell lung cancer (NSCLC). It is characterized by small airways and the hyperinflation of the lung. Patients with hyperinflated lung tend to have more reserved lung fun...

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Autores principales: Kwon, Oh-Beom, Yeo, Chang-Dong, Lee, Hwa-Young, Kang, Hye-Seon, Kim, Sung-Kyoung, Kim, Ju-Sang, Park, Chan-Kwon, Lee, Sang-Haak, Kim, Seung-Joon, Kim, Jin-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470520/
https://www.ncbi.nlm.nih.gov/pubmed/34575273
http://dx.doi.org/10.3390/jcm10184159
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author Kwon, Oh-Beom
Yeo, Chang-Dong
Lee, Hwa-Young
Kang, Hye-Seon
Kim, Sung-Kyoung
Kim, Ju-Sang
Park, Chan-Kwon
Lee, Sang-Haak
Kim, Seung-Joon
Kim, Jin-Woo
author_facet Kwon, Oh-Beom
Yeo, Chang-Dong
Lee, Hwa-Young
Kang, Hye-Seon
Kim, Sung-Kyoung
Kim, Ju-Sang
Park, Chan-Kwon
Lee, Sang-Haak
Kim, Seung-Joon
Kim, Jin-Woo
author_sort Kwon, Oh-Beom
collection PubMed
description Chronic obstructive pulmonary disease (COPD) is one of the most frequently occurring concomitant diseases in patients with non-small cell lung cancer (NSCLC). It is characterized by small airways and the hyperinflation of the lung. Patients with hyperinflated lung tend to have more reserved lung function than conventionally predicted after lung cancer surgery. The aim of this study was to identify other indicators in predicting postoperative lung function after lung resection for lung cancer. Patients with NSCLC who underwent curative lobectomy with mediastinal lymph node dissection from 2017 to 2019 were included. Predicted postoperative FEV(1) (ppoFEV(1)) was calculated using the formula: preoperative FEV(1) × (19 segments-the number of segments to be removed) ÷ 19. The difference between the measured postoperative FEV(1) and ppoFEV(1) was defined as an outcome. Patients were categorized into two groups: preserved FEV(1) if the difference was positive and non-preserved FEV(1), if otherwise. In total, 238 patients were included: 74 (31.1%) in the FEV(1) non-preserved group and 164 (68.9%) in the FEV(1) preserved group. The proportion of preoperative residual volume (RV)/total lung capacity (TLC) ≥ 40% in the FEV(1) non-preserved group (21.4%) was lower than in the preserved group (36.1%) (p = 0.03). In logistic regression analysis, preoperative RV/TLC ≥ 40% was related to postoperative FEV1 preservation. (adjusted OR, 2.02, p = 0.041). Linear regression analysis suggested that preoperative RV/TLC was positively correlated with a significant difference. (p = 0.004) Preoperative RV/TLC ≥ 40% was an independent predictor of preserved lung function in patients undergoing curative lobectomy with mediastinal lymph node dissection. Preoperative RV/TLC is positively correlated with postoperative lung function.
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spelling pubmed-84705202021-09-27 The Value of Residual Volume/Total Lung Capacity as an Indicator for Predicting Postoperative Lung Function in Non-Small Lung Cancer Kwon, Oh-Beom Yeo, Chang-Dong Lee, Hwa-Young Kang, Hye-Seon Kim, Sung-Kyoung Kim, Ju-Sang Park, Chan-Kwon Lee, Sang-Haak Kim, Seung-Joon Kim, Jin-Woo J Clin Med Article Chronic obstructive pulmonary disease (COPD) is one of the most frequently occurring concomitant diseases in patients with non-small cell lung cancer (NSCLC). It is characterized by small airways and the hyperinflation of the lung. Patients with hyperinflated lung tend to have more reserved lung function than conventionally predicted after lung cancer surgery. The aim of this study was to identify other indicators in predicting postoperative lung function after lung resection for lung cancer. Patients with NSCLC who underwent curative lobectomy with mediastinal lymph node dissection from 2017 to 2019 were included. Predicted postoperative FEV(1) (ppoFEV(1)) was calculated using the formula: preoperative FEV(1) × (19 segments-the number of segments to be removed) ÷ 19. The difference between the measured postoperative FEV(1) and ppoFEV(1) was defined as an outcome. Patients were categorized into two groups: preserved FEV(1) if the difference was positive and non-preserved FEV(1), if otherwise. In total, 238 patients were included: 74 (31.1%) in the FEV(1) non-preserved group and 164 (68.9%) in the FEV(1) preserved group. The proportion of preoperative residual volume (RV)/total lung capacity (TLC) ≥ 40% in the FEV(1) non-preserved group (21.4%) was lower than in the preserved group (36.1%) (p = 0.03). In logistic regression analysis, preoperative RV/TLC ≥ 40% was related to postoperative FEV1 preservation. (adjusted OR, 2.02, p = 0.041). Linear regression analysis suggested that preoperative RV/TLC was positively correlated with a significant difference. (p = 0.004) Preoperative RV/TLC ≥ 40% was an independent predictor of preserved lung function in patients undergoing curative lobectomy with mediastinal lymph node dissection. Preoperative RV/TLC is positively correlated with postoperative lung function. MDPI 2021-09-15 /pmc/articles/PMC8470520/ /pubmed/34575273 http://dx.doi.org/10.3390/jcm10184159 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kwon, Oh-Beom
Yeo, Chang-Dong
Lee, Hwa-Young
Kang, Hye-Seon
Kim, Sung-Kyoung
Kim, Ju-Sang
Park, Chan-Kwon
Lee, Sang-Haak
Kim, Seung-Joon
Kim, Jin-Woo
The Value of Residual Volume/Total Lung Capacity as an Indicator for Predicting Postoperative Lung Function in Non-Small Lung Cancer
title The Value of Residual Volume/Total Lung Capacity as an Indicator for Predicting Postoperative Lung Function in Non-Small Lung Cancer
title_full The Value of Residual Volume/Total Lung Capacity as an Indicator for Predicting Postoperative Lung Function in Non-Small Lung Cancer
title_fullStr The Value of Residual Volume/Total Lung Capacity as an Indicator for Predicting Postoperative Lung Function in Non-Small Lung Cancer
title_full_unstemmed The Value of Residual Volume/Total Lung Capacity as an Indicator for Predicting Postoperative Lung Function in Non-Small Lung Cancer
title_short The Value of Residual Volume/Total Lung Capacity as an Indicator for Predicting Postoperative Lung Function in Non-Small Lung Cancer
title_sort value of residual volume/total lung capacity as an indicator for predicting postoperative lung function in non-small lung cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470520/
https://www.ncbi.nlm.nih.gov/pubmed/34575273
http://dx.doi.org/10.3390/jcm10184159
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