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Actions and Roles of FSH in Germinative Cells

Follicle stimulating hormone (FSH) is produced by the pituitary gland in a coordinated hypothalamic–pituitary–gonadal (HPG) axis event, plays important roles in reproduction and germ cell development during different phases of reproductive development (fetal, neonatal, puberty, and adult life), and...

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Autores principales: Recchia, Kaiana, Jorge, Amanda Soares, Pessôa, Laís Vicari de Figueiredo, Botigelli, Ramon Cesar, Zugaib, Vanessa Cristiane, de Souza, Aline Fernanda, Martins, Daniele dos Santos, Ambrósio, Carlos Eduardo, Bressan, Fabiana Fernandes, Pieri, Naira Caroline Godoy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470522/
https://www.ncbi.nlm.nih.gov/pubmed/34576272
http://dx.doi.org/10.3390/ijms221810110
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author Recchia, Kaiana
Jorge, Amanda Soares
Pessôa, Laís Vicari de Figueiredo
Botigelli, Ramon Cesar
Zugaib, Vanessa Cristiane
de Souza, Aline Fernanda
Martins, Daniele dos Santos
Ambrósio, Carlos Eduardo
Bressan, Fabiana Fernandes
Pieri, Naira Caroline Godoy
author_facet Recchia, Kaiana
Jorge, Amanda Soares
Pessôa, Laís Vicari de Figueiredo
Botigelli, Ramon Cesar
Zugaib, Vanessa Cristiane
de Souza, Aline Fernanda
Martins, Daniele dos Santos
Ambrósio, Carlos Eduardo
Bressan, Fabiana Fernandes
Pieri, Naira Caroline Godoy
author_sort Recchia, Kaiana
collection PubMed
description Follicle stimulating hormone (FSH) is produced by the pituitary gland in a coordinated hypothalamic–pituitary–gonadal (HPG) axis event, plays important roles in reproduction and germ cell development during different phases of reproductive development (fetal, neonatal, puberty, and adult life), and is consequently essential for fertility. FSH is a heterodimeric glycoprotein hormone of two dissociable subunits, α and β. The FSH β-subunit (FSHβ) function starts upon coupling to its specific receptor: follicle-stimulating hormone receptor (FSHR). FSHRs are localized mainly on the surface of target cells on the testis and ovary (granulosa and Sertoli cells) and have recently been found in testicular stem cells and extra-gonadal tissue. Several reproduction disorders are associated with absent or low FSH secretion, with mutation of the FSH β-subunit or the FSH receptor, and/or its signaling pathways. However, the influence of FSH on germ cells is still poorly understood; some studies have suggested that this hormone also plays a determinant role in the self-renewal of germinative cells and acts to increase undifferentiated spermatogonia proliferation. In addition, in vitro, together with other factors, it assists the process of differentiation of primordial germ cells (PGCLCs) into gametes (oocyte-like and SSCLCs). In this review, we describe relevant research on the influence of FSH on spermatogenesis and folliculogenesis, mainly in the germ cell of humans and other species. The possible roles of FSH in germ cell generation in vitro are also presented.
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spelling pubmed-84705222021-09-27 Actions and Roles of FSH in Germinative Cells Recchia, Kaiana Jorge, Amanda Soares Pessôa, Laís Vicari de Figueiredo Botigelli, Ramon Cesar Zugaib, Vanessa Cristiane de Souza, Aline Fernanda Martins, Daniele dos Santos Ambrósio, Carlos Eduardo Bressan, Fabiana Fernandes Pieri, Naira Caroline Godoy Int J Mol Sci Review Follicle stimulating hormone (FSH) is produced by the pituitary gland in a coordinated hypothalamic–pituitary–gonadal (HPG) axis event, plays important roles in reproduction and germ cell development during different phases of reproductive development (fetal, neonatal, puberty, and adult life), and is consequently essential for fertility. FSH is a heterodimeric glycoprotein hormone of two dissociable subunits, α and β. The FSH β-subunit (FSHβ) function starts upon coupling to its specific receptor: follicle-stimulating hormone receptor (FSHR). FSHRs are localized mainly on the surface of target cells on the testis and ovary (granulosa and Sertoli cells) and have recently been found in testicular stem cells and extra-gonadal tissue. Several reproduction disorders are associated with absent or low FSH secretion, with mutation of the FSH β-subunit or the FSH receptor, and/or its signaling pathways. However, the influence of FSH on germ cells is still poorly understood; some studies have suggested that this hormone also plays a determinant role in the self-renewal of germinative cells and acts to increase undifferentiated spermatogonia proliferation. In addition, in vitro, together with other factors, it assists the process of differentiation of primordial germ cells (PGCLCs) into gametes (oocyte-like and SSCLCs). In this review, we describe relevant research on the influence of FSH on spermatogenesis and folliculogenesis, mainly in the germ cell of humans and other species. The possible roles of FSH in germ cell generation in vitro are also presented. MDPI 2021-09-18 /pmc/articles/PMC8470522/ /pubmed/34576272 http://dx.doi.org/10.3390/ijms221810110 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Recchia, Kaiana
Jorge, Amanda Soares
Pessôa, Laís Vicari de Figueiredo
Botigelli, Ramon Cesar
Zugaib, Vanessa Cristiane
de Souza, Aline Fernanda
Martins, Daniele dos Santos
Ambrósio, Carlos Eduardo
Bressan, Fabiana Fernandes
Pieri, Naira Caroline Godoy
Actions and Roles of FSH in Germinative Cells
title Actions and Roles of FSH in Germinative Cells
title_full Actions and Roles of FSH in Germinative Cells
title_fullStr Actions and Roles of FSH in Germinative Cells
title_full_unstemmed Actions and Roles of FSH in Germinative Cells
title_short Actions and Roles of FSH in Germinative Cells
title_sort actions and roles of fsh in germinative cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470522/
https://www.ncbi.nlm.nih.gov/pubmed/34576272
http://dx.doi.org/10.3390/ijms221810110
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