An Extensive Metabolomics Workflow to Discover Cardiotoxin-Induced Molecular Perturbations in Microtissues

Discovering modes of action and predictive biomarkers of drug-induced structural cardiotoxicity offers the potential to improve cardiac safety assessment of lead compounds and enhance preclinical to clinical translation during drug development. Cardiac microtissues are a promising, physiologically r...

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Detalles Bibliográficos
Autores principales: Bowen, Tara J., Hall, Andrew R., Lloyd, Gavin R., Weber, Ralf J. M., Wilson, Amanda, Pointon, Amy, Viant, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470535/
https://www.ncbi.nlm.nih.gov/pubmed/34564460
http://dx.doi.org/10.3390/metabo11090644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470535/
https://www.ncbi.nlm.nih.gov/pubmed/34564460
http://dx.doi.org/10.3390/metabo11090644

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