Cargando…

The Effects of Two Nrf2 Activators, Bardoxolone Methyl and Omaveloxolone, on Retinal Ganglion Cell Survival during Ischemic Optic Neuropathy

Nonarteritic anterior ischemic optic neuropathy (NAION) is one of the most common acute optic neuropathies that affect the over 55-year-old population. NAION causes the loss of visual function, and it has no safe and effective therapy. Bardoxolone methyl (methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chien, Jia-Ying, Chou, Yu-Yau, Ciou, Jhih-Wei, Liu, Fang-Yun, Huang, Shun-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470542/ https://www.ncbi.nlm.nih.gov/pubmed/34573098 http://dx.doi.org/10.3390/antiox10091466

Ejemplares similares

The Protective Effects of n-Butylidenephthalide on Retinal Ganglion Cells during Ischemic Injury
por: Chou, Yu-Yau, et al.
Publicado: (2022)

Protective Effects of Oroxylin A on Retinal Ganglion Cells in Experimental Model of Anterior Ischemic Optic Neuropathy
por: Chien, Jia-Ying, et al.
Publicado: (2021)

Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates
por: Reisman, Scott A, et al.
Publicado: (2019)

Modeling Retinal Ganglion Cell Dysfunction in Optic Neuropathies
por: Porciatti, Vittorio, et al.
Publicado: (2021)

Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease
por: Sun, Qi, et al.
Publicado: (2021)

Bardoxolone methyl inhibits the infection of rabies virus via Nrf2 pathway activation in vitro
por: Chi, Ying Lin, et al.
Publicado: (2023)

Antioxidants in Kidney Diseases: The Impact of Bardoxolone Methyl
por: Rojas-Rivera, Jorge, et al.
Publicado: (2012)

Protective Effect of Pioglitazone on Retinal Ganglion Cells in an Experimental Mouse Model of Ischemic Optic Neuropathy
por: Sun, Ming-Hui, et al.
Publicado: (2022)

Bardoxolone methyl: drug development for diabetic kidney disease
por: Kanda, Hironori, et al.
Publicado: (2020)

Bardoxolone Methyl Ameliorates Myocardial Ischemia/Reperfusion Injury by Activating the Nrf2/HO-1 Signaling Pathway
por: Huang, Anwu, et al.
Publicado: (2023)

Safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia
por: Lynch, David R., et al.
Publicado: (2018)

Safety and Efficacy of Omaveloxolone in Friedreich Ataxia (MOXIe Study)
por: Lynch, David R., et al.
Publicado: (2020)

NLRP3 inflammasome in retinal ganglion cell loss in optic neuropathy
por: Feng, Liang, et al.
Publicado: (2016)

The pattern of retinal ganglion cell dysfunction in Leber hereditary optic neuropathy
por: Majander, A., et al.
Publicado: (2017)

Osteopontin drives retinal ganglion cell resiliency in glaucomatous optic neuropathy
por: Zhao, Mengya, et al.
Publicado: (2023)

Orphan Drugs In Development For The Treatment Of Friedreich’s Ataxia: Focus On Omaveloxolone
por: Ghanekar, Shaila D, et al.
Publicado: (2019)

Anticholestatic Effect of Bardoxolone Methyl on Hepatic Ischemia-reperfusion Injury in Rats
por: Kim, Joohyun, et al.
Publicado: (2020)

Retinal Ganglion Cell Layer Thinning Within One Month of Presentation for Non-Arteritic Anterior Ischemic Optic Neuropathy
por: Kupersmith, Mark J., et al.
Publicado: (2016)

The Novel Nrf2 Activator Omaveloxolone Regulates Microglia Phenotype and Ameliorates Secondary Brain Injury after Intracerebral Hemorrhage in Mice
por: Hu, Libin, et al.
Publicado: (2022)

Neuroinflammation, Microglia and Implications for Retinal Ganglion Cell Survival and Axon Regeneration in Traumatic Optic Neuropathy
por: Au, Ngan Pan Bennett, et al.
Publicado: (2022)

46 Bardoxolone-methyl Microparticles Ameliorate Immune Dysfunction Following Burn and Inhalation Injury Through the NRF2/KEAP1 Axis
por: Seim, Roland F, et al.
Publicado: (2022)

Cell-Based Neuroprotection of Retinal Ganglion Cells in Animal Models of Optic Neuropathies
por: Hu, Yue, et al.
Publicado: (2021)

Therapeutic Strategies for Attenuation of Retinal Ganglion Cell Injury in Optic Neuropathies: Concepts in Translational Research and Therapeutic Implications
por: Fu, Lin, et al.
Publicado: (2019)

Variable effects of omaveloxolone (RTA408) on primary fibroblasts with mitochondrial defects
por: Zighan, Madleen, et al.
Publicado: (2022)

Omaveloxolone and TX63682 are hepatoprotective in the STAM mouse model of nonalcoholic steatohepatitis
por: Reisman, Scott A., et al.
Publicado: (2020)

The Effects of Lycium chinense, Cuscuta chinensis, Senna tora, Ophiopogon japonicus, and Dendrobium nobile Decoction on a Dry Eye Mouse Model
por: Yang, Cheng-Chan, et al.
Publicado: (2022)

Macular ganglion cell complex injury in different stages of anterior ischemic optic neuropathy
por: Zhang, Wei, et al.
Publicado: (2021)

Keap1-Nrf2 signaling activation by Bardoxolone-methyl ameliorates high glucose-induced oxidative injury in human umbilical vein endothelial cells
por: Yang, Jing-Lei, et al.
Publicado: (2020)

Bardoxolone Methyl Prevents Mesenteric Fat Deposition and Inflammation in High-Fat Diet Mice
por: Dinh, Chi H. L., et al.
Publicado: (2015)

Bardoxolone methyl analog attenuates proteinuria-induced tubular damage by modulating mitochondrial function
por: Nagasu, Hajime, et al.
Publicado: (2019)

Bardoxolone methyl ameliorates osteoarthritis by inhibiting osteoclastogenesis and protecting the extracellular matrix against degradation
por: Yang, Ruijia, et al.
Publicado: (2023)

Establishing the ground squirrel as a superb model for retinal ganglion cell disorders and optic neuropathies
por: Xiao, Xuan, et al.
Publicado: (2021)

Peripapillary retinal nerve fiber layer and macular ganglion cell complex thickness in patients with chronic phase of nonarteritic anterior ischemic optic neuropathy
por: Şahin, Muhammed, et al.
Publicado: (2018)

A Point Mutation at C151 of Keap1 of Mice Abrogates NRF2 Signaling, Cytoprotection in Vitro, and Hepatoprotection in Vivo by Bardoxolone Methyl (CDDO-Me)
por: Gatbonton-Schwager, Tonibelle, et al.
Publicado: (2023)

Oroxylin A promotes retinal ganglion cell survival in a rat optic nerve crush model
por: Lin, Shu-Fang, et al.
Publicado: (2017)

Nonarteritic Anterior Ischemic Optic Neuropathy Induced Retinal Folds and Deformations
por: Kupersmith, Mark J., et al.
Publicado: (2017)

Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties
por: Wang, Yan-Yang, et al.
Publicado: (2014)

The Effect of Melatonin on Retinal Ganglion Cell Survival in Ischemic Retina
por: Park, Sang-Woo, et al.
Publicado: (2012)

Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo
por: Jiang, Zengxin, et al.
Publicado: (2022)

Early Ganglion Cell or Macular Vessel Loss After Acute Nonarteritic Anterior Ischemic Optic Neuropathy?
por: Fard, Masoud Aghsaei, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ngnai206pp694chfa7ot0brn28