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Luteinizing Hormone Regulation of Inter-Organelle Communication and Fate of the Corpus Luteum

The corpus luteum is an endocrine gland that synthesizes the steroid hormone progesterone. luteinizing hormone (LH) is a key luteotropic hormone that stimulates ovulation, luteal development, progesterone biosynthesis, and maintenance of the corpus luteum. Luteotropic and luteolytic factors precisel...

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Autores principales: Przygrodzka, Emilia, Plewes, Michele R., Davis, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470545/
https://www.ncbi.nlm.nih.gov/pubmed/34576135
http://dx.doi.org/10.3390/ijms22189972
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author Przygrodzka, Emilia
Plewes, Michele R.
Davis, John S.
author_facet Przygrodzka, Emilia
Plewes, Michele R.
Davis, John S.
author_sort Przygrodzka, Emilia
collection PubMed
description The corpus luteum is an endocrine gland that synthesizes the steroid hormone progesterone. luteinizing hormone (LH) is a key luteotropic hormone that stimulates ovulation, luteal development, progesterone biosynthesis, and maintenance of the corpus luteum. Luteotropic and luteolytic factors precisely regulate luteal structure and function; yet, despite recent scientific progress within the past few years, the exact mechanisms remain largely unknown. In the present review, we summarize the recent progress towards understanding cellular changes induced by LH in steroidogenic luteal cells. Herein, we will focus on the effects of LH on inter-organelle communication and steroid biosynthesis, and how LH regulates key protein kinases (i.e., AMPK and MTOR) responsible for controlling steroidogenesis and autophagy in luteal cells.
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spelling pubmed-84705452021-09-27 Luteinizing Hormone Regulation of Inter-Organelle Communication and Fate of the Corpus Luteum Przygrodzka, Emilia Plewes, Michele R. Davis, John S. Int J Mol Sci Review The corpus luteum is an endocrine gland that synthesizes the steroid hormone progesterone. luteinizing hormone (LH) is a key luteotropic hormone that stimulates ovulation, luteal development, progesterone biosynthesis, and maintenance of the corpus luteum. Luteotropic and luteolytic factors precisely regulate luteal structure and function; yet, despite recent scientific progress within the past few years, the exact mechanisms remain largely unknown. In the present review, we summarize the recent progress towards understanding cellular changes induced by LH in steroidogenic luteal cells. Herein, we will focus on the effects of LH on inter-organelle communication and steroid biosynthesis, and how LH regulates key protein kinases (i.e., AMPK and MTOR) responsible for controlling steroidogenesis and autophagy in luteal cells. MDPI 2021-09-15 /pmc/articles/PMC8470545/ /pubmed/34576135 http://dx.doi.org/10.3390/ijms22189972 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Przygrodzka, Emilia
Plewes, Michele R.
Davis, John S.
Luteinizing Hormone Regulation of Inter-Organelle Communication and Fate of the Corpus Luteum
title Luteinizing Hormone Regulation of Inter-Organelle Communication and Fate of the Corpus Luteum
title_full Luteinizing Hormone Regulation of Inter-Organelle Communication and Fate of the Corpus Luteum
title_fullStr Luteinizing Hormone Regulation of Inter-Organelle Communication and Fate of the Corpus Luteum
title_full_unstemmed Luteinizing Hormone Regulation of Inter-Organelle Communication and Fate of the Corpus Luteum
title_short Luteinizing Hormone Regulation of Inter-Organelle Communication and Fate of the Corpus Luteum
title_sort luteinizing hormone regulation of inter-organelle communication and fate of the corpus luteum
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470545/
https://www.ncbi.nlm.nih.gov/pubmed/34576135
http://dx.doi.org/10.3390/ijms22189972
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